Some of the main trajectories of urban development in RomanS yria and Asia Minor have been studied in detail. Not much attention, however,h as been paid to the fact that in some places the urban can be seen as the product of sacred. There are various examples of large rural sanctuaries thato ver time gained urban characteristics and eventuallyd eveloped into cities. During the second wave of urbanisation in Syria in the 2 nd /3 rd centuries CE, some of those "urbaniseds anctuaries" weref ormallyr ecognised as cities. This close entanglement between sanctuaries and the emergence of urbanity was not confined to the pagan period. Christian places of worship could triggert he urbanisation of rural places,t oo. Resafa, for example, developed from as mall border post into aflourishing city of Sergiopolis due to the popularity of the martyrium of S. Sergios. It is remarkable that in most cases the cities that developed around sanctuaries very quicklye mancipated themselvesf rom thoses anctuaries. The growingc omplexity of the cities' metabolism turned them into regional hubs in theiro wn right.They proved to be very resilient and maintained their urban role even aftert he sanctuaries thatinitiated the process of urbanisation werefinallya bandoned. 1I ntroduction Stating thatthe cities of the Eastern Empire did not decline in late antiquity is a commonplacet oday. Over the last3 0y ears, al arge array of studies has demonstrated the resilienceo fu rbanism in this region and highlighted the vivacity of urban life in the fourth to sixth centuries CE. The master narrative changed from decline to ac ontingent process of transformation.¹ Citiess uccessfully adapted to changingeconomic, political,social,religious, and environmental re- This workw as supported by the Danish NationalR esearch Foundation under the grant DNRF119-Centreo fE xcellence for Urban Network Evolutions (UrbNet).