NIR‐to‐NIR Two‐Photon Scanning Laser Microscopy Imaging of Single Nanoparticles Doped by Yb<sup>III</sup> Complexes

Bourdolle, Adrien; D’Aléo, Anthony; Philippot, Cécile; Baldeck, Patrice L.; Guyot, Y.; Dubois, Fabien; Ibanez, Alain; Andraud, Chantal; Brasselet, Sophie; Maury, Olivier

doi:10.1002/cphc.201500814

Cited by 8 publications

(4 citation statements)

References 72 publications

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“…The potential of 3D‐resolved two‐photon‐actuated nanomedicine has been exploited via various nanomaterials such as semiconductor and carbon nanodots, polymeric, organic, silicon, gold, graphene and graphene oxide, silica hybrid, and other inorganic nanomaterials. What are the advantages of silica‐based nanoparticles?…”

Section: Two‐photon‐sensitive Organosilica Nanomaterialsmentioning

confidence: 99%

Two‐Photon‐Excited Silica and Organosilica Nanoparticles for Spatiotemporal Cancer Treatment

Croissant

Zink

Raehm

et al. 2018

Adv Healthcare Materials

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Coherent two-photon-excited (TPE) therapy in the near-infrared (NIR) provides safer cancer treatments than current therapies lacking spatial and temporal selectivities because it is characterized by a 3D spatial resolution of 1 µm and very low scattering. In this review, the principle of TPE and its significance in combination with organosilica nanoparticles (NPs) are introduced and then studies involving the design of pioneering TPE-NIR organosilica nanomaterials are discussed for bioimaging, drug delivery, and photodynamic therapy. Organosilica nanoparticles and their rich and well-established chemistry, tunable composition, porosity, size, and morphology provide ideal platforms for minimal side-effect therapies via TPE-NIR. Mesoporous silica and organosilica nanoparticles endowed with high surface areas can be functionalized to carry hydrophobic and biologically unstable two-photon absorbers for drug delivery and diagnosis. Currently, most light-actuated clinical therapeutic applications with NPs involve photodynamic therapy by singlet oxygen generation, but low photosensitizing efficiencies, tumor resistance, and lack of spatial resolution limit their applicability. On the contrary, higher photosensitizing yields, versatile therapies, and a unique spatial resolution are available with engineered two-photon-sensitive organosilica particles that selectively impact tumors while healthy tissues remain untouched. Patients suffering pathologies such as retinoblastoma, breast, and skin cancers will greatly benefit from TPE-NIR ultrasensitive diagnosis and therapy.

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Section: Two‐photon‐sensitive Organosilica Nanomaterialsmentioning

confidence: 99%

Two‐Photon‐Excited Silica and Organosilica Nanoparticles for Spatiotemporal Cancer Treatment

Croissant

Zink

Raehm

et al. 2018

Adv Healthcare Materials

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“…The case of NdL 3 was particular, as a linear dependence of the luminescence intensity versus the incident laser power was observed (followed by a slight saturation effect at higher laser power), signifying a dominant 1 P excitation process. This phenomenon was rationalized by the 4f–4f absorption band in this range and especially the 4 F 7/2 ← 4 I 9/2 (740 nm) and 2 H 9/2 ← 4 I 9/2 (800 nm) transitions [24,26,27] . Despite the forbidden nature of the 4f–4f transitions for 1 P excitation, they were still more probable than the nonlinear 2 P absorption in the CT antenna and completely masked its contribution to the sensitisation of the Nd(III) emission.…”

Section: Resultsmentioning

confidence: 93%

“…4 I 9/2 (800 nm) transitions. [24,26,27] Despite the forbidden nature of the 4f-4f transitions for 1 P excitation, they were still more probable than the nonlinear 2 P absorption in the CT antenna and completely masked its contribution to the sensitisation of the Nd(III) emission. Our attempts to circumvent this problem by shifting the excitation wavelength to 700 nm (at higher energies than the 4f-4f transitions) still yielded the Nd(III)-based 1 P excitation, as the spectral dispersion of the laser overlapped with the 4f-4f absorption.…”

Section: Two-photon Absorption Propertiesmentioning

confidence: 99%

Comprehensive Photophysical and Nonlinear Spectroscopic Study of Thioanisolyl‐Picolinate Triazacyclononane Lanthanide Complexes

Akl,

Bridou,

Hojorat

et al. 2024

Eur J Inorg Chem

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Detailed photophysical studies of luminescent lanthanide complexes are presented and elaborated using a newly developed thioanisolyl‐picolinate antenna and the related tacn macrocyclic ligand. The new ligand proved to sensitise Nd(III), Sm(III), Eu(III) and Yb(III) emission. Eu(III) complex showed complete energy transfer, yielding high quantum yield (44%) and brightness, while the Tb(III) analogue underwent a thermally activated back‐energy transfer, resulting in a strong oxygen quenching of the triplet excited state. Transient absorption spectroscopy measurements of Gd(III), Tb(III) and Eu(III) compounds confirmed the sensitization processes upon the charge‐transfer antenna excitation. The triplet excited state lifetime of the Tb(III) complex was 5‐times longer than that of the Gd(III) analogue. In contrast, the triplet state was totally quenched by the energy transfer to the 4f‐metal ion in the Eu(III) species. Nonlinear two‐photon absorption highlighted efficient biphotonic sensitization in Eu(III) and Sm(III) complexes. In case of the Nd(III) compound, one‐photon absorption in 4f‐4f transitions was predominant, despite the excitation at the antenna two‐photon band. This phenomenon was due to the Nd(III) 4f‐4f transitions overlapping with the wavelength‐doubled absorption of the complex

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“…The unique optical properties of the lanthanide(III) cations have triggered some of the most exciting recent developments in coordination chemistry as their characteristic luminescence can be a crucial advantage for a broad range of applications including lasers, electroluminescent and telecommunication devices, bioanalytical assays and fluorescence imaging [1][2][3][4][5][6][7][8][9][10][11]. One of the particularities of some of the lanthanide(III) cations is their abilities to emit in the near-infrared (NIR); this range is in a strong demand for biological imaging for example as the use of such light allows the discrimination of the lanthanide(III) signal related to the analyte from the background biological fluorescence [12][13][14][15]. Free lanthanide(III) ions have very low extinction coefficients as most of f-f transitions are forbidden which limit the number of photons they can emit and the corresponding detection sensitivity.…”

Section: Introductionmentioning

confidence: 99%

Exploring the ability of the nalidixate to sensitize visible and near-infrared emitting lanthanide(III) cations

Eliseeva

Liasotkyi

Golovach

et al. 2017

Methods Appl. Fluoresc.

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Recently, a strong interest has been directed towards near-infrared (NIR) emitting lanthanide(III) compounds as they do possess complementary advantages in respect to organic molecules and semi-conductor nanocrystals, especially in the fields of biological analysis and imaging. To benefit from their emission, a key requirement to fulfill is the sensitization of lanthanide(III) cations with an appropriate chromophore. This condition is especially challenging to address for the lanthanide(III) cations emitting in the NIR. The quest for new chromophores well adapted to the NIR-emitting lanthanide(III) ions is an important direction of research in order to broaden the rationalization of the parameters that control the sensitization process. In this work, we have investigated the ability of a readily available chromophoric ligand, the nalidixic acid, to sensitize lanthanide(III) cations with a specific interest for those emitting in the NIR. We have therefore performed an extensive study of the luminescence properties of lanthanide(III) complexes emitting in the visible and in the NIR ranges formed in situ upon mixing the corresponding Ln(III) nitrates (Ln(III) = Pr, Nd, Sm, Eu, Tb, Dy, Ho, Tm, Yb) with nalidixic acid (HNA) in a 1:3 molar ratio in the presence of a base. Luminescence spectra, quantum yields and luminescence lifetimes have been measured and discussed. The red emission of Eu with a quantum yield value of 5.90(3)%, red and NIR of Pr (7(1) · 10 and 5.6(1) · 10%) and Ho (9.3(2) · 10 and 2.8(1) · 10%), green of Tb (5.21(5)%), yellow and NIR of Dy (0.51(2) and 0.065(4)%), orange and NIR of Sm (0.147(5) and 0.037(2)%), as well as NIR of Nd (0.0321(2)%) and Yb (0.021(1)%) were observed. These results and analysis show that the nalidixate is a versatile chromophoric ligand that is suitable for the sensitization of nine different lanthanide(III) cations, five of them emitting in the NIR.

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NIR‐to‐NIR Two‐Photon Scanning Laser Microscopy Imaging of Single Nanoparticles Doped by Yb^III Complexes

Cited by 8 publications

References 72 publications

Two‐Photon‐Excited Silica and Organosilica Nanoparticles for Spatiotemporal Cancer Treatment

Two‐Photon‐Excited Silica and Organosilica Nanoparticles for Spatiotemporal Cancer Treatment

Comprehensive Photophysical and Nonlinear Spectroscopic Study of Thioanisolyl‐Picolinate Triazacyclononane Lanthanide Complexes

Exploring the ability of the nalidixate to sensitize visible and near-infrared emitting lanthanide(III) cations

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NIR‐to‐NIR Two‐Photon Scanning Laser Microscopy Imaging of Single Nanoparticles Doped by YbIII Complexes

Cited by 8 publications

References 72 publications

Two‐Photon‐Excited Silica and Organosilica Nanoparticles for Spatiotemporal Cancer Treatment

Two‐Photon‐Excited Silica and Organosilica Nanoparticles for Spatiotemporal Cancer Treatment

Comprehensive Photophysical and Nonlinear Spectroscopic Study of Thioanisolyl‐Picolinate Triazacyclononane Lanthanide Complexes

Exploring the ability of the nalidixate to sensitize visible and near-infrared emitting lanthanide(III) cations

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NIR‐to‐NIR Two‐Photon Scanning Laser Microscopy Imaging of Single Nanoparticles Doped by Yb^III Complexes