NIR responsive nanoenzymes via photothermal ablation and hypoxia reversal to potentiate the STING-dependent innate antitumor immunity

Li, Qianzhe; Yang, Mengyu; Sun, Xin; Wang, Qinxin; Yu, Beibei; Gong, Aihua; Zhang, Miaomiao; Du, F.

doi:10.1016/j.mtbio.2023.100566

Cited by 11 publications

(9 citation statements)

References 49 publications

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“…The disintegration of the PPCH increased with decreasing pH, indicating that the PPCH could achieve pH-responsive degradation in the acidic TME (pH ~6.5). 47,48 Regarding the mechanism of biodegradation, previous reports 49,50 noted that when the pH value of the solution decreased from 8.5 to 5, the thickness of the deposited polydopamine film gradually decreased, indicating that the π-π stacking and hydrogen bonding interactions between the drug and polydopamine were pH-sensitive. With the decrease in pH, which comes with an increase in the number of hydrogen atoms (protons), the chemical equilibrium shifts toward product degradation.…”

Section: Dovepressmentioning

confidence: 99%

Endogenous H2O2 Self-Replenishment and Sustainable Cascades Enhance the Efficacy of Sonodynamic Therapy

Du,

Teng,

Wang

et al. 2023

IJN

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Sonodynamic therapy (SDT), with its high tissue penetration and noninvasive advantages, represents an emerging approach to eradicating solid tumors. However, the outcomes of SDT are typically hampered by the low oxygen content and immunosuppression in the tumor microenvironment (TME). Accordingly, we constructed a cascade nanoplatform to regulate the TME and improve the anti-tumor efficiency of SDT. Methods: In this study, we rationally design cascade nanoplatform by incorporating immunostimulant hyaluronic acid (HA) and sonosensitizer chlorin e6 (Ce6) on the polydopamine nanocarrier that is pre-doped with platinum nanozymes (designated Ce6/ Pt@PDA-HA, PPCH). Results: The cascade reactions of PPCH are evidenced by the results that HA exhibits reversing immunosuppressive that converts M2 macrophages into M1 macrophages in situ, while producing H 2 O 2 , and then platinum nanozymes further catalyze the H 2 O 2 to produce O 2 , and O 2 produces abundant singlet oxygen ( 1 O 2 ) under the action of Ce6 and low-intensity focused ultrasound (LIFU), resulting in a domino effect and further amplifying the efficacy of SDT. Due to its pH responsiveness and mitochondrial targeting, PPCH effectively accumulates in tumor cells. Under LIFU irradiation, PPCH effectively reverses immunosuppression, alleviates hypoxia in the TME, enhances reactive oxygen species (ROS) generation, and enhances SDT efficacy for eliminating tumor cells in vivo and in vitro. Meanwhile, an in vivo dualmodal imaging including fluorescence and photoacoustic imaging achieves precise tumor diagnosis. Conclusion:This cascade nanoplatform will provide a promising strategy for enhancing SDT eradication against tumors by modulating immunosuppression and relieving hypoxia.

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Section: Dovepressmentioning

confidence: 99%

Endogenous H2O2 Self-Replenishment and Sustainable Cascades Enhance the Efficacy of Sonodynamic Therapy

Du,

Teng,

Wang

et al. 2023

IJN

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“…The prepared tissue sections were placed on a slide scanner to capture tissue images, which were then evaluated by experienced pathologists. [33][34] The detection of mouse blood samples Before treatment, blood tests were conducted on 4T1 tumor-bearing mice in the PDA&DOX@LAC + NIR group. Subsequently, PDA&DOX (4 mg/kg) was injected intravenously via the tail vein into the 4T1 tumorbearing mice.…”

Section: Histological Analysismentioning

confidence: 99%

Preparation of Environmentally Responsive PDA&DOX@LAC Live Drug Carrier for synergistic tumor therapy

Liu,

Zhao

2024

Preprint

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The development of intelligent, environmentally responsive, and biocompatible photothermal system holds significant importance for the photothermal combined therapy of tumors. In this study, inspired by lactobacillus, we prepared a biomimetic nanoplatform, PDA&DOX@LAC, for tumor photothermal-chemotherapy by integrating the chemotherapeutic drug doxorubicin (DOX) with dopamine through oxidative polymerization to form polydopamine on the surface of LAC. The PDA&DOX@LAC nanoplatform not only achieves precise and controlled release of DOX based on the slightly acidic microenvironment of tumor tissues, but also exhibits enzyme-like properties to alleviate tumor hypoxia. Under near-infrared light irradiation, it effectively induces photothermal ablation of tumor cells, enhances cellular uptake of DOX with increasing temperature, and thus efficiently inhibits tumor cell growth. Moreover, in vivo experiments further confirmed that photothermal therapy combined with PDA&DOX@LAC induces tumor cells apoptosis, releases tumor-associated antigens, and is engulfed by dendritic cells, activating cytotoxic T lymphocytes, thereby effectively suppressing tumor growth and prolonging the survival period of 4T1 tumor-bearing mice. Therefore, the PDA&DOX@LAC nanoplatform holds immense potential in precise tumor targeting and photothermal combined therapy, providing valuable insights and theoretical foundations for the development of novel tumor treatment strategies based on endogenous substances within the body.

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“…Manganese ions directly activate the STING signaling and induce innate antitumor immunity 140 . NIR‐responsive nanoenzymes that dope manganese into the ovalbumin‐templated Prussian blue nanoparticles alleviate the hypoxic tumor microenvironment as well as destroy tumor cells through provoking ICD under NIR irradiation 141 . In addition, the nanoenzymes elevate the cyclic GMP‐AMP synthase (cGAS)‐STING signaling to facilitate the maturation and the antigen cross‐presentation capacity of DCs, further activating CTLs and memory T lymphocytes.…”

Section: Stimuli‐responsive Nanodelivery Systems In Amplifying Icdmentioning

confidence: 99%

Stimuli‐responsive nanodelivery systems for amplifying immunogenic cell death in cancer immunotherapy

Liu

Yang

et al. 2023

Immunological Reviews

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SummaryImmunogenic cell death (ICD) is a special pattern of tumor cell death, enabling to elicit tumor‐specific immune response via the release of damage‐associated molecular patterns and tumor‐associated antigens in the tumor microenvironment. ICD‐induced immunotherapy holds the promise for completely eliminating tumors and long‐term protective antitumor immune response. Increasing ICD inducers have been discovered for boosting antitumor immunity via evoking ICD. Nonetheless, the utilization of ICD inducers remains insufficient owing to serious toxic reactions, low localization efficiency within the tumor microenvironmental niche, etc. For overcoming such limitations, stimuli‐responsive multifunctional nanoparticles or nanocomposites with ICD inducers have been developed for improving immunotherapeutic efficiency via lowering toxicity, which represent a prospective scheme for fostering the utilization of ICD inducers in immunotherapy. This review outlines the advances in near‐infrared (NIR)‐, pH‐, redox‐, pH‐ and redox‐, or NIR‐ and tumor microenvironment‐responsive nanodelivery systems for ICD induction. Furthermore, we discuss their clinical translational potential. The progress of stimuli‐responsive nanoparticles in clinical settings depends upon the development of biologically safer drugs tailored to patient needs. Moreover, an in‐depth comprehending of ICD biomarkers, immunosuppressive microenvironment, and ICD inducers may accelerate the advance in smarter multifunctional nanodelivery systems to further amplify ICD.

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NIR responsive nanoenzymes via photothermal ablation and hypoxia reversal to potentiate the STING-dependent innate antitumor immunity

Cited by 11 publications

References 49 publications

Endogenous H2O2 Self-Replenishment and Sustainable Cascades Enhance the Efficacy of Sonodynamic Therapy

Endogenous H2O2 Self-Replenishment and Sustainable Cascades Enhance the Efficacy of Sonodynamic Therapy

Preparation of Environmentally Responsive PDA&DOX@LAC Live Drug Carrier for synergistic tumor therapy

Stimuli‐responsive nanodelivery systems for amplifying immunogenic cell death in cancer immunotherapy

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NIR responsive nanoenzymes via photothermal ablation and hypoxia reversal to potentiate the STING-dependent innate antitumor immunity

Cited by 11 publications

References 49 publications

Endogenous H2O2 Self-Replenishment and Sustainable Cascades Enhance the Efficacy of Sonodynamic Therapy

Endogenous H2O2 Self-Replenishment and Sustainable Cascades Enhance the Efficacy of Sonodynamic Therapy

Preparation of Environmentally Responsive PDA&amp;DOX@LAC Live Drug Carrier for synergistic tumor therapy

Stimuli‐responsive nanodelivery systems for amplifying immunogenic cell death in cancer immunotherapy

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Preparation of Environmentally Responsive PDA&DOX@LAC Live Drug Carrier for synergistic tumor therapy