NIR Reflection Measurements of Hemoglobin and Cytochrome aa3 in Healthy Tissue and Tumors

Steinberg, F.; Röhrborn, Hans‐Joachim; Otto, T.; Scheufler, Kai-Michael; Streffer, C.

doi:10.1007/978-1-4615-5399-1_11

Cited by 30 publications

(15 citation statements)

References 10 publications

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“…An immunohistochemical analysis showed a 35% higher microvessel density in corresponding normal breast tissues compared to mammary carcinoma (Eberhard et al, 2000). This finding could be explained by the lower oxygen consumption rate of tumour cells (Steinberg et al, 1997) and their resistance to apoptosis under hypoxic conditions (Graeber et al, 1996). As tumour cells are viable at lower oxygen concentrations, they can survive at greater distances from the vasculature than normal cells (Hlatky et al, 2002).…”

Section: Discussionmentioning

confidence: 99%

Angiogenesis and lymphangiogenesis are downregulated in primary breast cancer

et al. 2009

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BACKGROUND: Angiogenesis and lymphangiogenesis are considered to play key roles in tumour growth, progression and metastasis. However, targeting tumour angiogenesis in clinical trials showed only modest efficacy. We therefore scrutinised the concept of tumour angiogenesis and lymphangiogenesis by analysing the expression of crucial markers involved in these processes in primary breast cancer. METHODS: We analysed the expression of angiogenic, lymphangiogenic or antiangiogenic factors, their respective receptors and specific markers for endothelial and lymphendothelial cells by quantitative real-time RT-PCR in primary breast cancer and compared the expression profiles to non-cancerous, tumour-adjacent tissues and breast tissues from healthy women. RESULTS: We found decreased mRNA amounts of major angiogenic and lymphangiogenic factors in tumour compared to healthy tissues, whereas antiangiogenic factors were upregulated. Concomitantly, angiogenic and lymphangiogenic receptors were downregulated in breast tumours. This antiangiogenic, antilymphangiogenic microenvironment was even more pronounced in aggressive tumours and accompanied by reduced amounts of endothelial and lymphatic endothelial cell markers. CONCLUSION: Primary breast tumours are not a site of highly active angiogenesis and lymphangiogenesis. Selection for tumour cells that survive with minimal vascular supply may account for this observation in clinical apparent tumours.

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Section: Discussionmentioning

confidence: 99%

Angiogenesis and lymphangiogenesis are downregulated in primary breast cancer

et al. 2009

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“…38 Using NIR, Hull et al 41 showed that rat mammary tumors have altered oxygen saturation content when under the influence of carbogen, a high oxygen content gas. Kidney and brain tumors were found to contain significant variation in total hemoglobin content, oxyhemoglobin, and hemoglobin saturation compared to the surrounding tissue, 42 while melanomas examined by Bono et al 43 demonstrated a lower NIR reflectance in the short-wavelength region than other skin lesions.…”

Section: Tumor Detectionmentioning

confidence: 98%

Noninvasive Diagnoses by Near‐Infrared Spectroscopy

Alam

2001

Handbook of Vibrational Spectroscopy

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The sections in this article are Introduction The Study of Human Peripheral Muscle Organ Perfusion and Metabolism Skin Monitoring Tumor Detection Detection of p H in Blood and Tissue Lipids and Proteins Body Composition Conclusion

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“…Thus, the number of tumor cells that can be supported by a vessel varies, and this in turn influences the vascular density of the tumor. Despite their often considerable angiogenic activity, certain human tumors can exhibit lower microvessel densities than the corresponding normal tissues [15]. Also, MVD following anti-angiogenic therapy is determined by the time-dependent ratio of capillary to tumor cell dropout, which in turn could result in increased, decreased or unchanged values of MVD [16].…”

Section: To Facilitate Preliminary Testing Of Potential New Therapeutmentioning

confidence: 99%

Circulating and imaging markers for angiogenesis

Pathak

Hochfeld

et al. 2008

Angiogenesis

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Abundant preclinical and indirect clinical data have for several decades convincingly supported the notion that anti-angiogenesis is an effective strategy for the inhibition of tumor growth. The recent success achieved in patients with metastatic colon carcinoma using a neutralizing antibody directed against vascular endothelial growth factor (VEGF) has translated preclinical optimism into a clinical reality.With this transformation in the field of angiogenesis has come a need for reliable surrogate markers. A surrogate marker by definition serves as a substitute for the underlying process in question, and in the case of angiogenesis, microvessel density (usually in so-called "hot-spots") has until now been the most widely used parameter. However, this parameter is more akin to a static "snapshot" and does not lend itself either to the dynamic in situ assessment of the status of the tumor microvasculature or to the molecular factors that regulate its growth and involution. This has led to an acute need for developing circulating and imaging markers of angiogenesis that can be monitored in vivo at repeated intervals in large number of patients with a variety of tumors in a non-invasive manner. Such markers of angiogenesis are the subject of this review.

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NIR Reflection Measurements of Hemoglobin and Cytochrome aa3 in Healthy Tissue and Tumors

Cited by 30 publications

References 10 publications

Angiogenesis and lymphangiogenesis are downregulated in primary breast cancer

Angiogenesis and lymphangiogenesis are downregulated in primary breast cancer

Noninvasive Diagnoses by Near‐Infrared Spectroscopy

Circulating and imaging markers for angiogenesis

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