NIR photothermal-activable drug-conjugated microcapsules for in vitro targeted delivery and release: An alternative treatment of diabetic retinopathy

Stoia, Daria; Nistor, Mădălina; Suciu, Maria; Borlan, Raluca; Campu, Andreea; Rugină, Dumitriţa; Maniu, Dana; Aştilean, Simion; Focșan, Monica

doi:10.1016/j.ijpharm.2023.122700

Cited by 7 publications

(2 citation statements)

References 35 publications

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“…Recent developments in the biomedical field have brought us to advanced technologies of the medical world such as targeted drug delivery systems (DDSs), rapid wound healing, antibacterial wound dressing, bone regeneration, and dentistry . However, the existing technology and biomedical treatment still needs to be controlled carefully by humans due to its nonresponsive properties with respect to the working environment that leads to ineffective treatment, risking a patient’s health and decreasing the biomaterial lifespan. − Therefore, the research on smart biomaterials has gained interest over the past decades to meet the demands of various stimuli-responsive biomaterials for broad applications. − For example, Scialla et al successfully synthesized doxorubicin-loaded magnetic lipid-based nanovehicles exhibiting pH induced tumor associated macrophages (TAMs) for fighting triple-negative breast cancer (TNC) .…”

Section: Introductionmentioning

confidence: 99%

Chitosan-Based Smart Biomaterials for Biomedical Applications: Progress and Perspectives

Budiarso,

Rini,

Tsalsabila

et al. 2023

ACS Biomater. Sci. Eng.

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Over the past decade, smart and functional biomaterials have escalated as one of the most rapidly emerging fields in the life sciences because the performance of biomaterials could be improved by careful consideration of their interaction and response with the living systems. Thus, chitosan could play a crucial role in this frontier field because it possesses many beneficial properties, especially in the biomedical field such as excellent biodegradability, hemostatic properties, antibacterial activity, antioxidant properties, biocompatibility, and low toxicity. Furthermore, chitosan is a smart and versatile biopolymer due to its polycationic nature with reactive functional groups that allow the polymer to form many interesting structures or to be modified in various ways to suit the targeted applications. In this review, we provide an up-to-date development of the versatile structures of chitosan-based smart biomaterials such as nanoparticles, hydrogels, nanofibers, and films, as well as their application in the biomedical field. This review also highlights several strategies to enhance biomaterial performance for fast growing fields in biomedical applications such as drug delivery systems, bone scaffolds, wound healing, and dentistry.

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Section: Introductionmentioning

confidence: 99%

Chitosan-Based Smart Biomaterials for Biomedical Applications: Progress and Perspectives

Budiarso,

Rini,

Tsalsabila

et al. 2023

ACS Biomater. Sci. Eng.

View full text Add to dashboard Cite

show abstract

“…Active targeting is commonly attained by surface modification of nanocarriers with ligands recognizing and binding with receptors expressed on membranes of target cells 11 , 12 , 13 , 14 , 15 , 16 . Actively and passively targeted nanomedicines have been exploited as imaging tools, in addition to therapeutics, in recent years with impressive preclinical and clinical potentials 14 , 17 , 18 , 19 , 20 , 21 , 22 .…”

Section: Introductionmentioning

confidence: 99%