NIR-II sensitive Co9S8/S-CDs@PEG nanocomposites with enhanced multi-enzyme mediated phototherapy

Kang, Keke; Wang, Limin; Ma, Yajie; Yu, Kai; Liu, Jingwei; Qu, Fengyu; Lin, Huiming

doi:10.1016/j.carbon.2022.06.012

Cited by 12 publications

(21 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“… Considering the redox pair between Co ions, Co-based nanomaterials always possess great nanozyme activity toward H 2 O 2 . , As displayed in Figure A, CPCs@PEG + H 2 O 2 solutions reveal the obvious bubbles and increased O 2 concentrations, indicating CAT activity based on the reaction of Co 3+ and H 2 O 2 (eq ). CAT behavior also is confirmed by the current response of CPC10 with the discontinuous addition of H 2 O 2 (0.1 mM), as displayed in Figure B.…”

Section: Resultsmentioning

confidence: 99%

Hollow CoP@N–Carbon Nanospheres: Heterostructure and Glucose-Enhanced Charge Separation for Sonodynamic/Starvation Therapy

Wang

Song

Choi³

et al. 2023

ACS Appl. Mater. Interfaces

Self Cite

View full text Add to dashboard Cite

Sonodynamic therapy (SDT) can be described as ultrasonic (US) catalysis. Adequate charge separation is considered as effective means to promote reactive oxygen species (ROS). Here, hollow CoP@N–carbon@PEG (CPCs@PEG) nanospheres (∼60 nm) are prepared as sonosensitizers, showing greater ROS generation than pure CoP@PEG under US irradiation. Both 1O2 and ·O2 – are activation species that are determined by O2 and electrons. The great SDT performance of CPCs@PEG is ascribed to the heterostructure which promotes the separation and transfer for US-generated electrons and holes. In addition, holes can be further captured by endogenous glucose that is in favor of electron aggregation and ROS generation. Moreover, the consumption of glucose would decrease intracellular ATP for starvation therapy. Given the higher oxidation ability of Co3+, CPCs@PEG nanospheres possess catalase (CAT) activity to convert H2O2 into O2 for assisting ROS generation. Moreover, they also can oxidize glutathione (GSH) as a mimic GSH oxidase to break intratumor redox balance, facilitating oxidative stress. More importantly, the nanocomposites reveal good degradation ability dominated by the oxidation from insoluble phosphide into soluble phosphate, accelerating elimination via urine and feces within 14 days. CPCs@PEG nanospheres integrate the above effects not only to reveal great tumor inhibition ability but also to excite immune activation for anticancer.

show abstract

Section: Resultsmentioning

confidence: 99%

Hollow CoP@N–Carbon Nanospheres: Heterostructure and Glucose-Enhanced Charge Separation for Sonodynamic/Starvation Therapy

Wang

Song

Choi³

et al. 2023

ACS Appl. Mater. Interfaces

Self Cite

View full text Add to dashboard Cite

show abstract

“…In addition, free biothiol in cancer cells was bound with the CDs surface, which can enhance PDT. Recently, Kang and his colleagues [ 57 ] synthesized Co 9 S 8 /S-CDs@PEG (CSCs@PEG) nanocomposites by a two-step hydrothermal treatment. Firstly, sulfur-CDs were prepared with 3-mercaptopropionic acid as a precursor in an equal ratio of water and ethanol and the -SH was distributed on surface of the CDs.…”

Section: Preparation Of Pncdsmentioning

confidence: 99%

“…Additionally, Kang et al [ 57 ] synthesized Co 9 S 8 /S-CDs@PEG (CSCs@PEG) nanocomposites with a NIR-II excited PDT and PTT upon irradiation of 1064 nm (1.16 eV) ( Figure 7 ). The CSCs@PEG increased the temperature by 26.5 °C within 10 min (1064 nm, 0.8 W cm −2 ) and generated ROS including OH and · O 2 − .…”

Section: Application Of Pncds In Cancer Pdtmentioning

confidence: 99%

See 1 more Smart Citation

Recent Advances of Photoactive Near-Infrared Carbon Dots in Cancer Photodynamic Therapy

et al. 2023

View full text Add to dashboard Cite

Photodynamic therapy (PDT) is a treatment that employs exogenously produced reactive oxygen species (ROS) to kill cancer cells. ROS are generated from the interaction of excited-state photosensitizers (PSs) or photosensitizing agents with molecular oxygen. Novel PSs with high ROS generation efficiency is essential and highly required for cancer photodynamic therapy. Carbon dots (CDs), the rising star of carbon-based nanomaterial family, have shown great potential in cancer PDT benefiting from their excellent photoactivity, luminescence properties, low price, and biocompatibility. In recent years, photoactive near-infrared CDs (PNCDs) have attracted increasing interest in this field due to their deep therapeutic tissue penetration, superior imaging performance, excellent photoactivity, and photostability. In this review, we review recent progress in the designs, fabrication, and applications of PNCDs in cancer PDT. We also provide insights of future directions in accelerating the clinical progress of PNCDs.

show abstract

“…[64] Due to the high cost of noble metals, some non-noble metal oxides were also developed as GOx-mimics. Co 9 S 8 /S-CDs@PEG nanocomposites synthesized by Kang et al [65] exhibited GOx-like activity that could consume glucose to elevate the hydrogen peroxide level and inhibit the intracellular energy supply. Immunogenic death was triggered by increased ROS generation and nanozyme activity in maturing dendritic cells in tumor areas.…”

Section: Other Chemical Cuesmentioning

confidence: 99%

Physical and Chemical Cues at the Nano–Bio Interface for Immunomodulation

et al. 2022

View full text Add to dashboard Cite

Immunomodulation has made remarkable progress in fighting infectious disease and cancer. Conventionally, immunomodulation largely relies on chemical/biochemical agents, which, unfortunately, suffer from sever off-target adverse effects. Recent insights into nano-bio interactions suggest that nanomaterials can directly participate in immunomodulation. A range of physical and chemical cues at the nano-bio interface have been harnessed to regulate diverse immuno-signaling for disease control and treatment. In this Minireview, we summarize recent studies on the physical and chemical cues enabled by intrinsic nanomaterials to trigger immunological signaling. First, we discuss physical cues mediated by surface topography, hydrophobicity, charge, and heat at the nano-bio interface for immunomodulation. Then, various nanomaterials enabled chemical cues, such as metal species and oxidative species are outlined. Finally, our perspectives on challenges and possible future directions are provided.

show abstract

NIR-II sensitive Co9S8/S-CDs@PEG nanocomposites with enhanced multi-enzyme mediated phototherapy

Cited by 12 publications

References 37 publications

Hollow CoP@N–Carbon Nanospheres: Heterostructure and Glucose-Enhanced Charge Separation for Sonodynamic/Starvation Therapy

Hollow CoP@N–Carbon Nanospheres: Heterostructure and Glucose-Enhanced Charge Separation for Sonodynamic/Starvation Therapy

Recent Advances of Photoactive Near-Infrared Carbon Dots in Cancer Photodynamic Therapy

Physical and Chemical Cues at the Nano–Bio Interface for Immunomodulation

Contact Info

Product

Resources

About