NIR-II photothermal therapy for effective tumor eradication enhanced by heterogeneous nanorods with dual catalytic activities

Bioorthogonal nanozymes: an emerging strategy for disease therapy

“…Three therapeutic modalities of PTT-BCT-CDT provided a promising paradigm in resolving the dilemmas (such as inadequate tumor suppression) encountered in single PTT therapy and driving the clinical application of bioorthogonal nanozymes. 37 Moreover, to develop a promising alternative to enhance the activity of CuNPs in the CuAAC reaction, Qu and coworkers constructed an attractive bioorthogonal nanozyme (MCNs-Cu) through in situ growing CuNPs on the mesoporous carbon nanospheres (MCNs). The experimental results about the catalytic activity of MCNs-Cu in the CuAAC reaction showed that the catalytic efficiency of MCNs-Cu was dual-promoted by the produced ROS and heat energy converted from light energy under NIR light irradiation.…”

“…Three therapeutic modalities of PTT–BCT–CDT provided a promising paradigm in resolving the dilemmas (such as inadequate tumor suppression) encountered in single PTT therapy and driving the clinical application of bioorthogonal nanozymes. 37…”

Rapid Regulation of Local Temperature and Transient Receptor Potential Vanilloid 1 Ion Channels with Wide-Field Plasmonic Thermal Microscopy

“…The classical temperature control techniques employ heating sources to conduct the heat transfer, which can be time consuming and nonuniform over the target surface. In recent decades, plasmon resonances in nanostructures, especially metallic nanoparticles, have been proved to be efficient in regulating localized heat rapidly and feasibly. , These nanometer-sized heaters are capable of harvesting light due to the internal decay of hot carriers, facilitating many practical applications, such as photothermal therapy, neuron activation, phase separation, , gas sensing, and heterogeneous catalysis. , However, localized heating achieved by metallic nanoparticles still suffers from poor space precision of heating due to the random distribution of metallic nanoparticles, resulting in bulk heating on the sample. Moreover, the nanocavities created by the tightly positioned metal nanoparticles may also generate excessive heat, leading to overheating on the target. , …”

“…In recent decades, plasmon resonances in nanostructures, especially metallic nanoparticles, have been proved to be efficient in regulating localized heat rapidly and feasibly. 1,2 These nanometer-sized heaters are capable of harvesting light due to the internal decay of hot carriers, facilitating many practical applications, such as photothermal therapy, 3 neuron activation, 4 phase separation, 5,6 gas sensing, 7 and heterogeneous catalysis. 8,9 However, localized heating achieved by metallic nanoparticles still suffers from poor space precision of heating due to the random distribution of metallic nanoparticles, resulting in bulk heating on the sample.…”

Rapid Regulation of Local Temperature and TRPV1 Ion Channels with Wide-Field Plasmonic Thermal Microscopy

“…In recent decades, plasmon resonances in nanostructures, especially metallic nanoparticles, have been proved to be efficient in regulating localized heat rapidly and feasibly 1,2 . These nanometer-sized heaters are capable of harvesting light due to the internal decay of hot carriers, facilitating many practical applications, such as photothermal therapy 3 , neuron activation 4 , phase separation 5,6 , gas sensing 7 , and heterogeneous catalysis 8,9 . However, localized heating achieved by metallic nanoparticles still suffers from poor space precision of heating due to the random distribution of metallic nanoparticles, resulting in bulk heating on the sample.…”