NIR-II light-modulated thermosensitive hydrogel for light-triggered cisplatin release and repeatable chemo-photothermal therapy

Ruan, Changping; Liu, Chanjuan; Hu, Hailu; Guo, Xiaolu; Jiang, Bang‐Ping; Liang, Hong; Shen, Xing‐Can

doi:10.1039/c9sc00375d

Cited by 104 publications

(69 citation statements)

References 42 publications

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“…18,19 Over the past several years, uorescence based imaging in the second near-infrared channel (NIR-II, 1000-1700 nm) has gained attention for its prominent merits and surpasses the conventional visible/NIR-I channels (700-900 nm) in terms of lower tissue scattering and minimal auto-uorescence, thus leading to signicant advances in imaging qualities including image depth and spatiotemporal resolution. [20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38] More recently, based on a benzobisthiadiazole (BBTD) acceptor, a series of small molecular dyes with a donor-acceptor-donor (D-A-D) architecture have been developed. The reduced energy gap between the hybridized highest occupied molecular orbital (HOMO) and lowest unoccupied molecular orbital (LUMO) levels in these molecular systems shied the uorescence emission spectrum from the NIR-I region to the NIR-II channel.…”

Section: Introductionmentioning

confidence: 99%

Rational design of a multifunctional molecular dye for dual-modal NIR-II/photoacoustic imaging and photothermal therapy

Zhang

et al. 2019

Chem. Sci.

143

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Section: Introductionmentioning

confidence: 99%

Rational design of a multifunctional molecular dye for dual-modal NIR-II/photoacoustic imaging and photothermal therapy

Zhang

et al. 2019

Chem. Sci.

143

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“…TEM images (Figure 1B) revealed that the size distribution of RuO 2 @OVA NA is suitable for further biological applications. [ 21 ] These characteristics indicate that RuO 2 @OVA NAs have the potential to be used in tumor therapy. After these characterizations, the absorption spectrum of RuO 2 @OVA NAs was determined to study their absorption behavior (Figure 1C; Figure S2, Supporting Information).…”

Section: Resultsmentioning

confidence: 99%

Artificial Metalloprotein Nanoanalogues: In Situ Catalytic Production of Oxygen to Enhance Photoimmunotherapeutic Inhibition of Primary and Abscopal Tumor Growth

Huang

Ding

Jiang

et al. 2020

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Photoimmunotherapy (PIT) has shown enormous potential in not only eliminating primary tumors, but also inhibiting abscopal tumor growth. However, the efficacy of PIT is greatly limited by tumor hypoxia, which causes the attenuation of phototherapeutic efficacy and is a feature of the immunosuppressive tumor microenvironment (TME). In this study, one type of brand‐new artificial metalloprotein nanoanalogues is developed via reasonable integration of a “phototherapy‐enzymatic” RuO2 and a model antigen, ovalbumin (OVA) for enhanced PIT of cancers, namely, RuO2‐hybridized OVA nanoanalogues (RuO2@OVA NAs). The RuO2@OVA NAs exhibit remarkable photothermal/photodynamic capabilities under the near‐infrared light irradiation. More importantly, the photoacoustic imaging and immunofluorescence staining confirm that RuO2@OVA NAs can remarkably alleviate hypoxia via in situ catalysis of hydrogen peroxide overexpressed in the TME to produce oxygen (O2). This ushers a prospect of concurrently enhancing photodynamic therapy and reversing the immunosuppressive TME. Also, OVA, as a supplement to the immune stimulation induced by phototherapy, can activate immune responses. Finally, further combination with the cytotoxic T‐lymphocyte‐associated protein 4 checkpoint blockade is reported to effectively eliminate the primary tumor and inhibit distant tumor growth via the abscopal effect of antitumor immune responses, prolonging the survival.

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“…As a traditional treatment, chemotherapy is the most popular cooperator with NIR‐II PTT. Their combinational therapy has been achieved using 2D Nb 2 C nanosheets, ternary Janus NPs comprising MnO 2 @Au@CuS, poly( N ‐phenylglycine)–poly(ethylene glycol) (PNPG–PEG) hydrogels, and PPy‐contained alginate (PA)–Fe 3+ hydrogels . In these studies, the mesoporous structure such as the silica shell of 2D Nb 2 C nanosheet, the MnO 2 domain of Janus NP and the hydrogels served as carriers to encapsulate anticancer drugs.…”

Section: Nir‐ii Pttmentioning

confidence: 99%

Second Near‐Infrared Absorbing Agents for Photoacoustic Imaging and Photothermal Therapy

2019

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Photoacoustic (PA) imaging and photothermal therapy (PTT) provide useful tools for diagnosis and treatments of diseases. However, current applications of PA imaging and PTT are greatly limited by their relying on light source in the first near‐infrared (NIR) window (NIR‐I, 750–1000 nm), which shows shallow tissue penetration depth. Recently, this predicament is addressed by the use of second NIR (NIR‐II) light ranging from 1000 to 1700 nm due to reduced light–tissue interaction and increased allowable power density for light irradiation. Since a few endogenous biomolecules can absorb or emit NIR‐II light, it is necessary to develop contrast and therapeutic agents used for PA imaging and PTT in the NIR‐II window. This review summarizes the recent progresses of NIR‐II absorbing optical agents for PA imaging and PTT in living animal models. The prominent performance of NIR‐II PA imaging and NIR‐II PTT is first introduced with the use of optical agents, followed by discussion of the applications of NIR‐II PTT under the guidance of NIR‐I or NIR‐II PA imaging. At last, challenges and perspectives of NIR‐II absorbing optical agents for PA imaging and PTT are proposed.

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NIR-II light-modulated thermosensitive hydrogel for light-triggered cisplatin release and repeatable chemo-photothermal therapy

Abstract: An injectable, NIR-II light-modulated thermosensitive hydrogel is synthesized through supramolecular self-assembly for light-triggered cisplatin release and repeated chemo-photothermal therapy.

Cited by 104 publications

References 42 publications

Rational design of a multifunctional molecular dye for dual-modal NIR-II/photoacoustic imaging and photothermal therapy

Rational design of a multifunctional molecular dye for dual-modal NIR-II/photoacoustic imaging and photothermal therapy

Artificial Metalloprotein Nanoanalogues: In Situ Catalytic Production of Oxygen to Enhance Photoimmunotherapeutic Inhibition of Primary and Abscopal Tumor Growth

Second Near‐Infrared Absorbing Agents for Photoacoustic Imaging and Photothermal Therapy

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