NIR-II fluorescence imaging without intended excitation light

Ji, Aiyan; Lou, Hongyue; Li, Jiafeng; Hao, Yimeng; Wei, Xiaonan; Wu, Yibin; Zhao, Weili; Chen, Hao; Cheng, Zhen

doi:10.1039/d3sc06165e

Chem. Sci.

2024

DOI: 10.1039/d3sc06165e

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NIR-II fluorescence imaging without intended excitation light

Aiyan Ji,

Hongyue Lou,

Jiafeng Li

et al.

Abstract: Multi-wavelength LED excited NIR-II imaging strategy based on a blue-shifted dye—TPA-TQT.

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Cited by 4 publications

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Insights into Molecular Lanthanide Complexes: Construction, Properties and Bioimaging and Biosensing Applications

Yang,

Hu,

Yang

et al. 2024

Adv Funct Materials

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The lanthanide complex, characterized by narrow emission bands, large Stokes shifts, long luminescence lifetime, robust resistance to photobleaching, and magnetic properties, affords significant promise for molecular imaging and biosensing applications. While most lanthanide complexes emitting visible light are extensively studied for cellular‐level detection and bioimaging, near‐infrared‐emitted (700–1700 nm) lanthanide compounds exhibit more favorable properties for bioimaging and biosensing, ascribed from deeper penetration and reduced bleaching effects. Besides, the magnetic lanthanide complex with higher magnetic resonance signals can enhance image resolution and sensitivity, offering more precise bioimaging analysis. However, the widespread use of high‐efficiency luminescence lanthanide complexes is currently impeded by the lack of design approaches for improving magnetic properties and sensitization chromophores with extended excitation and emission wavelengths. In this review, some fundamental theories and design strategies of lanthanide complexes are summarized for luminescence imaging, lifetime‐engineered imaging, magnetic resonance imaging, and dual‐modal imaging, and now highlight a selection of bioimaging and biosensing applications. The review addresses the existing gap in the literature by proposing some feasible approaches for improving the fluorescent and magnetic properties. Concurrently, future challenges and opportunities in the field of lanthanide complex probes are discussed.

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Insights into Molecular Lanthanide Complexes: Construction, Properties and Bioimaging and Biosensing Applications

Yang,

Hu,

Yang

et al. 2024

Adv Funct Materials

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A Small‐Molecule NIR‐II Probe for the Diagnosis of Hemorrhagic Diseases

Li,

Xu,

Chen

et al. 2024

Adv Healthcare Materials

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Numerous hemorrhagic disorders, particularly those presenting deep hemorrhage, pose diagnostic challenges, often leading to delayed treatment and severe outcomes. Near‐infrared (NIR)‐II fluorescence imaging offers advantages such as deep tissue penetration, real‐time visualization, and a high signal‐to‐background ratio, making it highly suitable for diagnosing hemorrhagic diseases. In this study, an NIR‐II fluorescent probe LJ‐2P carrying carboxylic and phosphoric acid groups is successfully applied for imaging hemorrhagic diseases. LJ‐2P demonstrates a strong affinity for fibrinogen and fibrin clots both computationally and experimentally, thus exhibiting increased brightness upon coagulation. As compared to Indocyanine Green, LJ‐2P provides a longer imaging window, higher imaging specificity, and signal‐to‐background ratio, as well as superior photobleaching resistance in three disease models: gastric, pulmonary, and cerebral hemorrhages. These results reveal that LJ‐2P demonstrates enhanced imaging capabilities, enabling precise identification of hemorrhagic sites.

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Novel activated NIR-II fluorescence/Ratio photoacoustic probe for dual-modality accurate imaging of palladium ions overload in mouse liver

Zhu,

Li,

et al. 2024

Journal of Hazardous Materials

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NIR-II fluorescence imaging without intended excitation light

Abstract: Multi-wavelength LED excited NIR-II imaging strategy based on a blue-shifted dye—TPA-TQT.

Cited by 4 publications

References 37 publications

Insights into Molecular Lanthanide Complexes: Construction, Properties and Bioimaging and Biosensing Applications

Insights into Molecular Lanthanide Complexes: Construction, Properties and Bioimaging and Biosensing Applications

A Small‐Molecule NIR‐II Probe for the Diagnosis of Hemorrhagic Diseases

Novel activated NIR-II fluorescence/Ratio photoacoustic probe for dual-modality accurate imaging of palladium ions overload in mouse liver

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