NIR-II fluorescence imaging guided tumor-specific NIR-II photothermal therapy enhanced by starvation mediated thermal sensitization strategy

Dai, Yeneng; Sun, Zhiquan; Zhao, Honghai; Qi, Dashan; Li, Xiangyu; Gao, Diya; Li, Meixing; Fan, Quli; Shen, Qingming; Huang, Wei

doi:10.1016/j.biomaterials.2021.120935

Cited by 79 publications

(68 citation statements)

References 46 publications

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“…Thus, combinational platform of BPNS and auranofin (BATNS) could overcome the shortcomings of BPNS and auranofin but retains their advantages, along with the combination therapy on cancer, which potentially improve the therapeutic efficacy. Moreover, an increasing number of literatures have reported that various stress proteins (such as heat shock protein, calreticulin and high mobility group protein B1) could be generated under PTT environment and improved the immunogenicity of tumor cells [ 31 – 34 ]. Therefore, the combination of PTT and BATNS application might show a better tumor ablation and a stronger induction on host immune response.…”

Section: Introductionmentioning

confidence: 99%

Black phosphorus-Au-thiosugar nanosheets mediated photothermal induced anti-tumor effect enhancement by promoting infiltration of NK cells in hepatocellular carcinoma

et al. 2022

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Background Hepatocellular carcinoma (HCC) is a heterogeneous cancer required combination therapy, such as photothermal therapy and chemotherapy. In recent years, cancer immunotherapies are rapidly evolving and are some of the most promising avenues to approach malignancies. Thus, the combination of the traditional therapies and immunotherapy in one platform may improve the efficacy for HCC treatment. Results In this work, we have prepared a black phosphorus (BP)-Au-thiosugar nanosheets (BATNS), in which Au-thiosugar coating and functionalization improved the stability of both black phosphorus nanosheets (BPNS) and gold ions in different simulated physiological environments. The compression of the BATNS band gap can convert more photon energy to heat generation compared with BPNS, resulting in higher photothermal conversion efficiency. The in vitro and in vivo results also revealed a stronger reduction on the hepatocellular carcinoma of mice and prolonged survival of disease models compared with BPNS. More importantly, BATNS showed an additional immune effect by increasing local NK cell infiltration but not T cell on the liver cancer treatment, and this immune effect was caused by the thermal effect of BATNS photothermal treatment. Conclusions The novel BATNS could improve the stability of BPNS and simultaneously combine the cancer thermotherapy and immunotherapy leaded by local NK cell infiltration, resulting in a better therapeutic efficacy on hepatocellular carcinoma. This work also provided a new path to design BP-based materials for biomedical applications. Graphical Abstract

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Section: Introductionmentioning

confidence: 99%

Black phosphorus-Au-thiosugar nanosheets mediated photothermal induced anti-tumor effect enhancement by promoting infiltration of NK cells in hepatocellular carcinoma

et al. 2022

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“…Dai et al provided novel therapeutic concepts by encapsulating 2DG and a newly synthesized semiconducting polymer termed DPQ inside FA-modified liposomes. 31 The synthetic nanodrug was named Lip(DPQ+2DG). FA awarded the system merit for its capacity of targeting malignant cells overexpressing folate receptors.…”

Section: Combined Therapy Targeting Glucose Metabolismmentioning

confidence: 99%

“…Here, we looked at studies that included methods consuming glucose 29 or limiting glucose uptake 30 and anabolic processes ( Figure 2 ). 31 Interventions on glucose metabolism without the use of GOx that are rarely mentioned before are also involved. The design concepts of these formulations, as well as their anticancer effects, are highlighted.…”

Section: Introductionmentioning

confidence: 99%

Glucose Metabolism Intervention-Facilitated Nanomedicine Therapy

Li¹,

Li²,

Ai³

et al. 2022

IJN

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Ordinarily, cancer cells possess features of abnormally increased nutrient intake and metabolic pathways. The disorder of glucose metabolism is the most important among them. Therefore, starvation therapy targeting glucose metabolism specifically, which results in metabolic disorders, restricted synthesis, and inhibition of tumor growth, has been developed for cancer therapy. However, issues such as inadequate targeting effectiveness and drug tolerance impede their clinical transformation. In recent years, nanomaterial-assisted starvation treatment has made significant progress in addressing these challenges, whether as a monotherapy or in combination with other medications. Herein, representative researches on the construction of nanosystems conducting starvation therapy are introduced. Elaborate designs and interactions between different treatment mechanisms are meticulously mentioned. Not only are traditional treatments based on glucose oxidase involved, but also newly sprung small molecule agents targeting glucose metabolism. The obstacles and potential for advancing these anticancer therapies were also highlighted in this review.

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“…(L) Tumor temperature of mice under different treatments as a function of 1064 nm laser irradiation time. Adapted from ( Yang et al, 2020c ; Yin et al, 2021b ) and ( Dai et al, 2021b ). Copyright © 2020 American Chemical Society, 2021 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, 2021 Elsevier.…”

Section: Nir-ii Fluorescence Imaging-based Phototheranosticsmentioning

confidence: 99%

“…Combination therapy which combines two or more therapeutic modalities into one system may have a better therapeutic efficacy than any single moldality ( Xu and Pu, 2021 ). To improve the efficacy of phototherapy, Dai et al (2021b) synthesized a TQ-based SP, DPQ, to develop an NIR-II fluorescence imaging-guided NIR-II photothermal/starvation combination therapeutic system (Lip(DPQ + 2DG) ( Figure 1I ). Lip (DPQ + 2DG) was prepared by encapsulating a TQ-based SP (DPQ) and 2-Deoxy-D-glucose (2DG) into folic acid modified DSPE-PEG (DSPE-PEG-FA) and 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC).…”

Section: Nir-ii Fluorescence Imaging-based Phototheranosticsmentioning

confidence: 99%

Thiadiazoloquinoxaline-Based Semiconducting Polymer Nanoparticles for NIR-II Fluorescence Imaging-Guided Photothermal Therapy

Liao²,

Lü³

et al. 2021

Front. Bioeng. Biotechnol.

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Phototheranostics have gained more and more attention in the field of cancer diagnosis and therapy. Among a variety of fluorophores for phototheranostics, semiconducting polymer nanoparticles (SPNs), which are usually constructed by encapsulating hydrophobic semiconducting polymers (SPs) with amphiphilic copolymers, have shown great promise. As second near-infrared (NIR-II) fluorescence imaging has both higher imaging resolution and deeper tissue penetration compared with first near-infrared (NIR-I) fluorescence imaging, NIR-II fluorescent SPNs have been widely designed and prepared. Among numerous structural units for semiconducting polymers (SPs) synthesis, thiadiazoloquinoxaline (TQ) has been proved as an efficient electron acceptor unit for constructing NIR-II fluorescent SPs by reacting with proper electron donor units. Herein, we summarize recent advances in TQ-based SPNs for NIR-II fluorescence imaging-guided cancer photothermal therapy. The preparation of TQ-based SPNs is first described. NIR-II fluorescence imaging-based and multimodal imaging-based phototheranostics are sequentially discussed. At last, the conclusion and future perspectives of this field are presented.

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NIR-II fluorescence imaging guided tumor-specific NIR-II photothermal therapy enhanced by starvation mediated thermal sensitization strategy

Cited by 79 publications

References 46 publications

Black phosphorus-Au-thiosugar nanosheets mediated photothermal induced anti-tumor effect enhancement by promoting infiltration of NK cells in hepatocellular carcinoma

Black phosphorus-Au-thiosugar nanosheets mediated photothermal induced anti-tumor effect enhancement by promoting infiltration of NK cells in hepatocellular carcinoma

Glucose Metabolism Intervention-Facilitated Nanomedicine Therapy

Thiadiazoloquinoxaline-Based Semiconducting Polymer Nanoparticles for NIR-II Fluorescence Imaging-Guided Photothermal Therapy

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