NIR-II fluorescence and PA imaging guided activation of STING pathway in photothermal therapy for boosting cancer immunotherapy by theranostic thermosensitive liposomes

Long, Qi; Yang, Yang; Liao, Fangling; Chen, Haoting; He, Dongyue; Li, Shengliang; Li, Pengcheng; Guo, Weisheng; Xiao, Yafang

doi:10.1039/d3tb00711a

Cited by 3 publications

(1 citation statement)

References 49 publications

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“…Recently, there have been reports of image-guided multimodal cancer therapies using liposomes in the NIR-II region. 101 Du et al introduced a novel nanomedicine termed PATSL for fluorescence imaging in the NIR-II and combinatorial therapy of glioblastoma. PATSL incorporated temperature-sensitive liposome (TSL) carriers, NIR-II-emissive molecule, and photothermal aggregation-induced emission (AIE) dyes [electron-acceptor moiety benzobisthiadiazole (BBT) conjugated with electron-donor molecule N , N -diphenyl-4-(1,2,2-triphenylvinyl)aniline (DPTPEA)], together with the chemotherapeutic agent paclitaxel (PTX).…”

Section: Nir-responsive Nanomaterialsmentioning

confidence: 99%

Review of NIR-responsive ‘‘Smart’’ carriers for photothermal chemotherapy

Karmakar,

Silswal,

Koner

2024

J. Mater. Chem. B

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Section: Nir-responsive Nanomaterialsmentioning

confidence: 99%

Review of NIR-responsive ‘‘Smart’’ carriers for photothermal chemotherapy

Karmakar,

Silswal,

Koner

2024

J. Mater. Chem. B

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Exploring the functionality of fluorescent liposomes in cancer: diagnosis and therapy

Prajapati,

Sharma,

Pareek

et al. 2024

Zeitschrift Für Naturforschung C

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Fluorescent liposomes are pivotal in cancer research, serving as adaptable vehicles for imaging and therapeutics. These small lipid vesicles, capable of encapsulating fluorescent dyes, offer precise visualization and monitoring of their targeted delivery to cancer cells. This review delves into the critical role fluorescent liposomes play in enhancing both cancer diagnosis and treatment. It provides an in-depth analysis of their structural features, fluorescent labeling techniques, targeting strategies, and the challenges and opportunities they present. In the domain of cancer diagnosis, the article sheds light on various imaging modalities enabled by fluorescent liposomes, including fluorescence imaging and multimodal techniques. Emphasis is placed on early detection strategies, exhibiting the utility of targeted contrast agents and biomarker recognition for enhanced diagnostic precision. Moving on to cancer treatment, the review discusses the sophisticated drug delivery mechanisms facilitated by fluorescent liposomes, focusing on chemotherapy and photodynamic therapy. Moreover, the exploration extends to targeted therapy, explaining the applications of fluorescent liposomes in gene delivery and RNA interference. In a nutshell, his article comprehensively explores the multifaceted impact of fluorescent liposomes on advancing cancer diagnosis and treatment, combining existing knowledge with emerging trends.

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Recent Progress in Photothermal, Photodynamic and Sonodynamic Cancer Therapy: Through the cGAS-STING Pathway to Efficacy-Enhancing Strategies

Fang,

Zhang,

Kong

et al. 2024

Molecules

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Photothermal, photodynamic and sonodynamic cancer therapies offer opportunities for precise tumor ablation and reduce side effects. The cyclic guanylate adenylate synthase-stimulator of interferon genes (cGAS-STING) pathway has been considered a potential target to stimulate the immune system in patients and achieve a sustained immune response. Combining photothermal, photodynamic and sonodynamic therapies with cGAS-STING agonists represents a newly developed cancer treatment demonstrating noticeable innovation in its impact on the immune system. Recent reviews have concentrated on diverse materials and their function in cancer therapy. In this review, we focus on the molecular mechanism of photothermal, photodynamic and sonodynamic cancer therapies and the connected role of cGAS-STING agonists in treating cancer.

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NIR-II fluorescence and PA imaging guided activation of STING pathway in photothermal therapy for boosting cancer immunotherapy by theranostic thermosensitive liposomes

Abstract: Photothermal immunotherapy has shown great potential for efficient cancer treatment. However, the immunosuppressive tumor microenvironment forms a heavy barrier for photothermal-induced anti-tumor immunity by inhibiting dendritic cells (DCs) maturation and...

Cited by 3 publications

References 49 publications

Review of NIR-responsive ‘‘Smart’’ carriers for photothermal chemotherapy

Review of NIR-responsive ‘‘Smart’’ carriers for photothermal chemotherapy

Exploring the functionality of fluorescent liposomes in cancer: diagnosis and therapy

Recent Progress in Photothermal, Photodynamic and Sonodynamic Cancer Therapy: Through the cGAS-STING Pathway to Efficacy-Enhancing Strategies

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