NIR-II emissive multifunctional AIEgen with single laser-activated synergistic photodynamic/photothermal therapy of cancers and pathogens

Xu, Yuling; Zhang, Yi; Li, Jun; An, Jusung; Li, Chonglu; Bai, Suya; Sharma, Amit; Deng, Ganzhen; Kim, Jong Seung; Sun, Yao

doi:10.1016/j.biomaterials.2020.120315

Cited by 109 publications

(74 citation statements)

References 66 publications

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“… Zeng et al (2018b) conjugated water-soluble and biocompatible small-molecule NIR-II dye H2a-4T with fetal bovine serum (FBS) and Cetuximab proteins to enhance the tumor targeting and achieved good PTT effect on colorectal cancer. Assorted dyes with NIR-II fluorescence were adopted and developed for use in PTT with good photothermal effect, and showed promising perspective of NIR-II dyes utilized for imaging-guided PTT ( Wang et al, 2019 ; Zhou et al, 2020a ; Xu et al, 2020b ; Chen et al, 2020 ; Sun et al, 2020 ).…”

Section: Nir-ii Absorbing Materialsmentioning

confidence: 99%

Recent Progress on NIR-II Photothermal Therapy

Zhang

et al. 2021

Front. Chem.

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Photothermal therapy is a very promising treatment method in the field of cancer therapy. The photothermal nanomaterials in near-infrared region (NIR-I, 750-900 nm) attracts extensive attention in recent years because of the good biological penetration of NIR light. However, the penetration depth is still not enough for solid tumors due to high tissue scattering. The light in the second near-infrared region (NIR-II, 1000-1700 nm) allows deeper tissue penetration, higher upper limit of radiation and greater tissue tolerance than that in the NIR-I, and it shows greater application potential in photothermal conversion. This review summarizes the photothermal properties of Au nanomaterials, two-dimensional materials, metal oxide sulfides and polymers in the NIR-II and their application prospects in photothermal therapy. It will arouse the interest of scientists in the field of cancer treatment as well as nanomedicine.

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Section: Nir-ii Absorbing Materialsmentioning

confidence: 99%

Recent Progress on NIR-II Photothermal Therapy

Zhang

et al. 2021

Front. Chem.

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“…81,82 Abnormal levels of these species are associated with many diseases. In addition, hypoxia 83,84 and acidic pH 85,86 are common pathological microenvironments. Therefore, monitoring the changes in hypoxia, pH, or the levels of various biomarkers in organisms is of great significance for the diagnosis and prognosis of related diseases.…”

Section: Activatable Photoacoustic Probesmentioning

confidence: 99%

Recent development of near-infrared photoacoustic probes based on small-molecule organic dye

Liu

Fan

et al. 2021

RSC Chem. Biol.

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“…We have presented a hypoxia-responsive probe TBTO allowing for NIR-I imaging and more importantly PA imaging in solid tumors. Although the fluorescence emission could cover the NIR-I area, NIR-II fluorophores featuring longer absorption and emission wavelengths are worth investigating in the future for hypoxia imaging in deep tissue with high resolution (Li et al, 2020b;Sun et al, 2019;Tu et al, 2019;Xu et al, 2020c).…”

Section: Limitations Of the Studymentioning

confidence: 99%

Hypoxia-activated probe for NIR fluorescence and photoacoustic dual-mode tumor imaging

et al. 2021

iScience

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Construction of tumor microenvironment responsive probe with more than one imaging modality, in particular toward hypoxia of solid tumors, is an appealing yet significantly challenging task. In this work, we designed a hypoxia-activated probe TBTO (Triphenylamine-Benzothiadiazole-Triphenylamine derivative featuring four diethylamino N-Oxide groups) for in vivo imaging. TBTO could undergo bioreduction in a hypoxic microenvironment to yield compound TBT sharing both near-infrared (NIR) aggregation-induced emission and strong twisted intramolecular charge transfer features, which endows the probe with excellent performance in NIR fluorescence and photoacoustic dual-mode tumor imaging. This study offers useful insights into designing a new generation agent for clinical cancer diagnosis.

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NIR-II emissive multifunctional AIEgen with single laser-activated synergistic photodynamic/photothermal therapy of cancers and pathogens

Cited by 109 publications

References 66 publications

Recent Progress on NIR-II Photothermal Therapy

Recent Progress on NIR-II Photothermal Therapy

Recent development of near-infrared photoacoustic probes based on small-molecule organic dye

Hypoxia-activated probe for NIR fluorescence and photoacoustic dual-mode tumor imaging

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