NIR Biosensing of Neurotransmitters in Stem Cell‐Derived Neural Interface Using Advanced Core–Shell Upconversion Nanoparticles

Rabie, Hudifah; Zhang, Yixiao; Pasquale, Nicholas; Lagos, Maureen J.; Batson, Philip E.; Lee, Ki‐Bum

doi:10.1002/adma.201806991

Cited by 106 publications

(81 citation statements)

References 50 publications

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“…[ 16 ] Utilizing physical stimuli, we also demonstrated that an application magnetic field manipulated physical uncaging of RGD‐presenting nanomaterials to temporally switch the regulation of cell adhesion. [ 17 ] Light [ 18 ] has been typically utilized to trigger photo‐induced chemical changes in the molecular structure utilizing photolabile molecules [ 19 ] or photoisomerization. [ 20 ] A recent study showed the feasibility of utilizing ultraviolet (UV) light to trigger UV‐mediated photocleavage of molecules to modulate the adhesion of macrophages via spatial photo‐patterning strategy.…”

Section: Introductionmentioning

confidence: 99%

Remote Manipulation of Slidable Nano‐Ligand Switch Regulates the Adhesion and Regenerative Polarization of Macrophages

Choi

Bae

Khatua

et al. 2020

Adv Funct Materials

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The development of materials capable of varying macroscale ligand distributions can emulate an extracellular matrix (ECM) remodeling and regulate the adhesion and polarization of macrophages. In this report, negatively charged slidable nano‐ligands are assembled and then conjugated to a positively charged substrate via electrostatic interaction. The negatively charged slidable nano‐ligands are prepared by coating magnetic nanoparticles with a polymer linker and negatively charged RGD ligand. The nano‐ligand sliding is characterized under an external magnetic field, which spatiotemporally alters macroscale ligand density. To the best of knowledge, this is the first demonstration that magnetic maipulation of the macroscale ligand density inhibits inflammatory M1 phenotype but stimulates the adhesion and regenerative M2 phenotype of host macrophages. Furthermore, it is elucidated that the magnetic attraction of the slidable nano‐ligand facilitates the assembly of adhesion structures in macrophages, thereby stimulating their regenerative M2 phenotype. The design of ECM‐emulating materials that allow remote, spatiotemporal, and reversible controllability of macroscale ligand density provides an appealing strategy in the spatiotemporal regulation of immunomodulatory tissue‐regenerative responses to implants in vivo.

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Section: Introductionmentioning

confidence: 99%

Remote Manipulation of Slidable Nano‐Ligand Switch Regulates the Adhesion and Regenerative Polarization of Macrophages

Choi

Bae

Khatua

et al. 2020

Adv Funct Materials

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“…[9,10] Research by Haro-González and co-workers demonstrates that the total fluorescence intensity of nanoparticle group not only depends on the number of particles, but also on the direction of the excitation polarization and the orientation of the UCNPs. studies obtained in the last decades are performed by a cluster of nanoparticles, which is quite different from that of an individual particle.…”

mentioning

confidence: 99%

“…studies obtained in the last decades are performed by a cluster of nanoparticles, which is quite different from that of an individual particle. [9,10] Research by Haro-González and co-workers demonstrates that the total fluorescence intensity of nanoparticle group not only depends on the number of particles, but also on the direction of the excitation polarization and the orientation of the UCNPs. [11] Unfortunately, a major obstacle for practical application of UCNPs at single particle level is still their weak luminescence.…”

mentioning

confidence: 99%

Atomic‐Level Passivation of Individual Upconversion Nanocrystal for Single Particle Microscopic Imaging

Min

Jing

Guo

et al. 2019

Adv Funct Materials

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Lanthanide-doped upconversion nanoparticles (UCNPs) have significant applications for single-molecule probes and high-resolution display. However, one of their major hurdles is the weak luminescence, and this remains a grand challenge to achieve at the single-particle level. Here, 484-fold luminescence enhancement in LuF 3 :Yb 3+ , Er 3+ rhombic flake UCNPs is achieved, thanks to the Yb 3+ -mediated local photothermal effect, and their original morphology, size, and good dispersibility are well preserved. These data show that the surface atomic structure of UCNPs as well as transfer from amorphous to ordered crystal structure is modulated by making use of the local photothermal conversion that is generated by the directional absorption of 980 nm light by Yb 3+ ions. The confocal luminescence images obtained by superresolution stimulated emission depletion also show the great enhancement of individual LuF 3 :Yb 3+ , Er 3+ nanoparticles; the high signal-to-noise ratio images indicate that the laser treatment technology opens the door for single particle imaging and practical application.The ORCID identification number(s) for the author(s) of this article can be found under https://doi.org/10.1002/adfm.201906137. studies obtained in the last decades are performed by a cluster of nanoparticles, which is quite different from that of an individual particle. [9,10] Research by Haro-González and co-workers demonstrates that the total fluorescence intensity of nanoparticle group not only depends on the number of particles, but also on the direction of the excitation polarization and the orientation of the UCNPs. [11] Unfortunately, a major obstacle for practical application of UCNPs at single particle level is still their weak luminescence. [12][13][14] Thus, it is necessary to find a useful strategy to optimize the optical properties of individual up-conversion nanoparticle (UCNP) for better luminescence efficiency.Complicated surface states of UCNPs play an important role in their upconversion efficiency, in which majority atoms combine with the enriched surface defects, leading a serious surface quenching effect. [15][16][17] To date, many surface passivation strategies, [18] like annealing treatment [17,19] and coating technology, [20,21] have been proposed for improving upconversion luminescence (UCL), however most of these efforts may not necessarily lead to the optimal enhancement at the single-particle level. This is because 1) annealing treatment can cause agglomeration of UCNPs and 2) the use of coreshell configuration is difficult to achieve in 1D and 2D core UCNPs. Thus, it is urgent to find a useful strategy that can not only efficiently passivate surface defects, but also maintain the good uniformity of particle size, morphology, and the excellent dispersibility.In this work, Yb 3+ -/Er 3+ -codoped LuF 3 UCNPs were synthesized by co-precipitation method, and irradiated by high-energy near-infrared (NIR) laser ( Figure S2, Supporting Information). Here, we propose photothermal conversion in the local lattice ...

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“…In addition to the Au nanoparticle, other nanomaterials have been used for neurotransmitter detection. UCNPs played the role of fluorescence emission, and graphene oxide exhibited the quenching effect in this system [64]. These particles are connected to each other by the π-π interaction of dopamine aptamer, and the dopamine could induce the dissociation of graphene oxide from the aptamer by the aptamer-dopamine binding event.…”

Section: Metallic Nanoparticle-based Fluorescence Sensing Strategies mentioning

confidence: 89%

“…If the MNP is composed of noble elements such as Au and Ag, the emitted light is not generated, which we call the quenching effect. On the other hand, emission light can be generated if the nanoparticle acceptors have fluorescent properties such as quantum dot (QD) and upconversion nanoparticle (UCNP) [63,64]. For activation of this phenomenon, there is a specific condition between fluorescent donor and acceptor.…”

Section: Metallic Nanoparticle-based Fluorescence Sensing Strategies mentioning

confidence: 99%

Metallic Nanoparticle-Based Optical Cell Chip for Nondestructive Monitoring of Intra/Extracellular Signals

et al. 2020

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The biosensing platform is noteworthy for high sensitivity and precise detection of target analytes, which are related to the status of cells or specific diseases. The modification of the transducers with metallic nanoparticles (MNPs) has attracted attention owing to excellent features such as improved sensitivity and selectivity. Moreover, the incorporation of MNPs into biosensing systems may increase the speed and the capability of the biosensors. In this review, we introduce the current progress of the developed cell-based biosensors, cell chip, based on the unique physiochemical features of MNPs. Mainly, we focus on optical intra/extracellular biosensing methods, including fluorescence, localized surface plasmon resonance (LSPR), and surface-enhanced Raman spectroscopy (SERS) based on the coupling of MNPs. We believe that the topics discussed here are useful and able to provide a guideline in the development of new MNP-based cell chip platforms for pharmaceutical applications such as drug screening and toxicological tests in the near future.

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NIR Biosensing of Neurotransmitters in Stem Cell‐Derived Neural Interface Using Advanced Core–Shell Upconversion Nanoparticles

Cited by 106 publications

References 50 publications

Remote Manipulation of Slidable Nano‐Ligand Switch Regulates the Adhesion and Regenerative Polarization of Macrophages

Remote Manipulation of Slidable Nano‐Ligand Switch Regulates the Adhesion and Regenerative Polarization of Macrophages

Atomic‐Level Passivation of Individual Upconversion Nanocrystal for Single Particle Microscopic Imaging

Metallic Nanoparticle-Based Optical Cell Chip for Nondestructive Monitoring of Intra/Extracellular Signals

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