NIR- and UV-dual responsive amphiphilic copolymer micelles with light-dissociable PAG-side groups

Wang, Youpeng; Guo, Li; Cheng, Ruidong; Zhang, Xuan; Jiang, Jinqiang

doi:10.1007/s00396-017-4013-0

Cited by 10 publications

(5 citation statements)

References 38 publications

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“…On the other hand, when a light‐sensitive moiety is located in the hydrophobic micellar core, the nanoaggregate can be photo‐stimulated to disassemble or modify its LCST. This is the case, for example, of photoacid generators, such as o ‐nitro benzylacrylate, 8,146,164 or N‐hydroxyphathalimide methacrylate, 165 which are photocleaved to yield hydrophilic and pH‐sensitive free acrylate groups. Coumarin moieties are incorporated in the design of functional polymers that can be used in electro‐optical studies, photoreversible systems, chiral stationary phases for HPLC, fluorescent tags and fluoroprobes 166 .…”

Section: Random‐ Block‐ and Random‐block Copolymersmentioning

confidence: 99%

Playing construction with the monomer toy box for the synthesis of multi‐stimuli responsive copolymers by reversible deactivation radical polymerization protocols

D’Acunzo

Masci

2021

Journal of Polymer Science

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In this review article, we survey the 2016–June 2021 scientific literature on the synthesis of multi‐stimuli responsive (MSR) polymers, the main focus being on reversible deactivation radical polymerization techniques (RDRPs, also known as controlled radical polymerizations). In fact, along more than 40 years of extensive research, RDRPs have boosted the synthesis of stimuli‐responsive polymers. RDRPs are now robust, versatile, relatively user‐friendly and even interconvertible, thus allowing control over composition, sequence, and topology of polymers. Such control can afford materials with well‐defined responses to physical, chemical, and biological external stimuli. Furthermore, “click” reactions are used to combine macromolecular precursors or to introduce specific functional groups in the target structure. As a result, MSR polymers are obtained from diverse combinations of commercial or specially synthesized building blocks arranged at will into desired sequences and architectures. Thanks to this versatility, self‐assembling polymeric structures are designed either to respond to triggers and perform specific applicative tasks, or to investigate the influence of structural variables on the responsivity of polymers. The “green” trend emerging in the field of responsive polymers and RDRPs is also briefly discussed.

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Section: Random‐ Block‐ and Random‐block Copolymersmentioning

confidence: 99%

Playing construction with the monomer toy box for the synthesis of multi‐stimuli responsive copolymers by reversible deactivation radical polymerization protocols

D’Acunzo

Masci

2021

Journal of Polymer Science

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“…The light hence does little harm to non-cancerous cells or tissues before it is mainly absorbed by photoabsorbers, viz. NIR light is little or no invasive [ 39 , 118 ]. Consequently, PTT displays many features, e.g., deeper penetration, less invasiveness, no DNA damage, no water absorption [ 7 , 119 ].…”

Section: Combination Of Chemotherapy With Photothermal Therapy Viamentioning

confidence: 99%

Polymer-Based Nanocarriers for Co-Delivery and Combination of Diverse Therapies against Cancers

Yan

Zhang

et al. 2018

Nanomaterials

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Cancer gives rise to an enormous number of deaths worldwide nowadays. Therefore, it is in urgent need to develop new therapies, among which combined therapies including photothermal therapy (PTT) and chemotherapy (CHT) using polymer-based nanocarriers have attracted enormous interest due to the significantly enhanced efficacy and great progress has been made so far. The preparation of such nanocarriers is a comprehensive task involving the cooperation of nanomaterial science and biomedicine science. In this review, we try to introduce and analyze the structure, preparation and synergistic therapeutic effect of various polymer-based nanocarriers composed of anti-tumor drugs, nano-sized photothermal materials and other possible parts. Our effort may bring benefit to future exploration and potential applications of similar nanocarriers.

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“…利用光致断裂基团作为门控, 通过光照刺激实现门控释药也是光致断裂型药物递送系统的一种新的设计思路 [20,21] . Cui 等 [20] 利用光致断裂基团 ONB 作为维持 α-环糊精(α-CD)超分子纳米阀的塞子, 阻塞载药纳米颗粒的介孔来控制药物分子的释放(图 14), 当该纳米复合物用 980 nm 激光照射时, 通过上转换材料(吸收 λ: 980 nm, 图 12 肿瘤低氧微环境激活的光触发药物分子的释放 [50] Figure 12 Light-triggered drug released by the tumor hypoxic microenvironment activation [50] (NP: nanoparticle, PET: photo-induced electron transfer) 图 13 (a) YSUCNPs 在 NIR 光触发下释放药物机理示意图; (b)前药分子 UV 光诱导断裂结构示意图; (c)荷瘤小鼠光触发治疗结果 [51] Figure 13 (a) The exploited mechanisms for NIR-regulated release of drugs from YSUCNPs; (b) the photocleavage reaction of prodrugs under UV light; (c) photographs of tumor-bearing mice injected with YSUCNP-ACCh, YSLnNP-ACCh and saline on the 1st day, and after treatment on the 9th day and 17th day [51] (YSUCNP-ACCh: ACCh-loaded yolk-shell structured upconversion nanoparticles; YSLnNP-ACCh: ACCh-loaded yolk-shell structured non-upconversion nanoparticles; Scale bars represent 1 cm) [52,53] , 1-乙酰基芘(1-Acetylpyrene) [54,55] , 苝 (Perylene) [56,57] , 钌配合物(Ruthenium complex) [58] 等. 图 14 NIR 光触发药物释放上转换纳米载药颗粒与光控释药过程 [20] Figure 14 Near-infrared light-triggered drug release of up-conversion nanoparticles and the process of light-controlled drug release (a: up-conversion nanoparticles(NaYF 4 :Tm.Yb), b: NaYF 4 , c: mesoporous silica(mSiO 2 ), d: α-cyclodextrin (α-CD)) [20] 3.2 光致异构型药物递送系统光致异构型药物递送系统是一类含有光致异构化基团的光响应性药物递送系统.…”

Section: 光致断裂基团作为门控分子的药物递送系统mentioning

confidence: 99%

Progress in Research of Photo-controlled Drug Delivery Systems

Zhang¹,

Qian²,

Wang³

2017

Acta Chim. Sinica

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The controlled drug delivery systems, due to their precise control of drug release in spatiotemporal level triggered by specific stimulating factors and advantages such as higher utilization ratio of drug, less side-effects to normal tissues and so forth, provide a new strategy for the precise treatment of many serious diseases, especially tumors. The materials that constitute the controlled drug delivery systems are called "smart materials" and they can respond to the stimuli of some internal (pH, redox, enzymes, etc.) or external (temperature, electrical/magnetic, ultrasonic and optical, etc.) environments. Before and after the response to the specific stimulus, the composition or conformational of smart materials will be changed, damaging the original balance of the delivery systems and releasing the drug from the delivery systems. Amongst them, the photo-controlled drug delivery systems, which display drug release controlled by light, demonstrated extensive potential applications, and received wide attention from researchers. In recent years, photo-controlled drug delivery systems based on different photo-responsive groups have been designed and developed for precise photo-controlled release of drugs. Herein, in this review, we introduced four photo-responsive groups including photocleavage groups, photoisomerization groups, photo-induced rearrangement groups and photocrosslinking groups, and their different photo-responsive mechanisms. Firstly, the photocleavage groups represented by O-nitrobenzyl are able to absorb the energy of the photons, inducing the cleavage of some specific covalent bonds. Secondly, azobenzenes, as a kind of photoisomerization groups, are able to convert reversibly between the apolar trans form and the polar cis form upon different light irradiation. Thirdly, 2-diazo-1,2-naphthoquinone as the representative of the photo-induced rearrangement groups will absorb specific photon energy, carrying out Wolff rearrangement reaction. Finally, coumarin is a promising category photocrosslinking groups that can undergo [2＋2] cycloaddition reactions under light irradiation. The research progress of photo-controlled drug delivery systems based on different photo-responsive mechanisms were mainly reviewed. Additionally, the existing problems and the future research perspectives of photo-controlled drug delivery systems were proposed.

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NIR- and UV-dual responsive amphiphilic copolymer micelles with light-dissociable PAG-side groups

Cited by 10 publications

References 38 publications

Playing construction with the monomer toy box for the synthesis of multi‐stimuli responsive copolymers by reversible deactivation radical polymerization protocols

Playing construction with the monomer toy box for the synthesis of multi‐stimuli responsive copolymers by reversible deactivation radical polymerization protocols

Polymer-Based Nanocarriers for Co-Delivery and Combination of Diverse Therapies against Cancers

Progress in Research of Photo-controlled Drug Delivery Systems

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