NIR analysis for batch process of ethanol precipitation coupled with a new calibration model updating strategy

Xu, Bing; Wu, Zhisheng; Lin, Zhaozhou; Sui, Chenglin; Shi, Xinyuan; Qiao, Yanjiang

doi:10.1016/j.aca.2012.01.022

Cited by 64 publications

(22 citation statements)

References 22 publications

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“…It generally refers to evaluation of raw materials, CS extraction, ultra¯ltration, oxidation, precipitation, drying, grinding and packaging. Above all, ethanol precipitation which will lead to an unstable product quality and di®erences between batches is the most important unit used in industrial production [11][12][13][14] and the relevance between NIRS and CS is still unclear.…”

Section: Introductionmentioning

confidence: 99%

The relevance study of effective information between near infrared spectroscopy and chondroitin sulfate in ethanol precipitation process

Ding

et al. 2014

J. Innov. Opt. Health Sci.

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Near infrared spectroscopy (NIRS) is based on molecular overtone and combination vibrations. It is di±cult to assign speci¯c features under complicated system. So it is necessary to¯nd the relevance between NIRS and target compound. For this purpose, the chondroitin sulfate (CS) ethanol precipitation process was selected as the research model, and 90 samples of 5 di®erent batches were collected and the content of CS was determined by modi¯ed carbazole method. The relevance between NIRS and CS was studied throughout optical pathlength, pretreatment methods and variables selection methods. In conclusion, the¯rst derivative with Savitzky-Golay (SG) smoothing was selected as the best pretreatment, and the best spectral region was selected using interval partial least squares (iPLS) method under 1 mm optical cell. A multivariate calibration model was established using PLS algorithm for determining the content of CS, and the root mean square error of prediction (RMSEP) is 3.934 gÁL À1 . This method will have great potential in process analytical technology in the future.

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Section: Introductionmentioning

confidence: 99%

The relevance study of effective information between near infrared spectroscopy and chondroitin sulfate in ethanol precipitation process

Ding

et al. 2014

J. Innov. Opt. Health Sci.

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“…This phenomenon is called over-fitting. Here, we have discussed the effect of different main factor numbers (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20). The result was shown as Fig.…”

Section: Effect Of Factor Numbersmentioning

confidence: 99%

“…However, near infrared spectroscopy (NIRS) which is mainly based on the overtone and combination bands arising from fundamental vibrations in the midinfrared region, provides a fast, nondestructive method, requiring no sample or minimal preparation and producing no waste in contrast with traditional analytical methods. In recent years, NIRS combined with chemometrics technique have attracted considerable attention for the purpose of quantification and qualification analysis in herbal medicine [1][2][3][4][5][6] .…”

Section: Introductionmentioning

confidence: 99%

NIR rapid assessments of Chinese material medica: simultaneous determination of three major active components of licorice

Zhou

et al. 2014

SPIE Proceedings

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Objective: A rapid and nondestructive method was used to quantitatively predict the content of three main active components (glycyrrhizin, liquiritin and isoliquiritin) in licorice by near infrared spectroscopy (NIRS). Methods: Diffuse reflectance spectra of licorice powder were obtained, the contents of glycyrrhizin, liquiritin and isoliquiritin were analyzed simultaneously by high-performance liquid chromatography (HPLC). The partial least squares (PLS) regression algorithm was used to establish the quantitative models. Several pretreatments such as multiplicative scatter correction (MSC), first derivative, second derivative and Savitzky-Golay (SG) smoothing were utilized to correct the scattering effect and eliminate the baseline shift in all spectra. The calibration equations produced the highest determination of coefficient values (R 2 ), the lowest root mean square error of calibration (RMSEC) and the lowest root mean square error of prediction (RMSEP) were used for the determination of glycyrrhizin, liquiritin and isoliquiritin. Results: The R 2 of glycyrrhizin, liquiritin and isoliquiritin were 0.999, 0.996 and 0.999, respectively. The RMSEC of glycyrrhizin, liquiritin and isoliquiritin were 1.14 mg/g, 0.77 mg/g and 0.068 mg/g respectively. The RMSEP of glycyrrhizin, liquiritin and isoliquiritin were 4.92 mg/g, 2.06 mg/g and 0.35 mg/g respectively. Conclusions: The results indicated that the NIRS method could be used for the rapid assessment of licorice.

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“…In the past decades, NIR has gained wide acceptance in the quality analysis in manufacturing process of traditional Chinese medicine including discrimination of herbal materials [13][14][15][16], intermediates [11,17], in the procedures of pharmaceutical technique including end point assessment of extraction process [1], elution process [18], purification process [19], alcohol precipitation [20,21] and also in the pharmaceutical products including granules [22], sustained release formulations [23], tablets [24,25], solid dispersions [26]. However, on line monitoring and quality control of oral solutions, used as a convenient dosage especially for children, by NIR were rarely reported.…”

Section: Introductionmentioning

confidence: 99%

On-line monitoring the extract process of Fu-fang Shuanghua oral solution using near infrared spectroscopy and different PLS algorithms

Kang

Liu

et al. 2016

Spectrochimica Acta Part A: Molecular and Biomolecular Spectros

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NIR analysis for batch process of ethanol precipitation coupled with a new calibration model updating strategy

Cited by 64 publications

References 22 publications

The relevance study of effective information between near infrared spectroscopy and chondroitin sulfate in ethanol precipitation process

The relevance study of effective information between near infrared spectroscopy and chondroitin sulfate in ethanol precipitation process

NIR rapid assessments of Chinese material medica: simultaneous determination of three major active components of licorice

On-line monitoring the extract process of Fu-fang Shuanghua oral solution using near infrared spectroscopy and different PLS algorithms

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