NIR‐Actuated Remote Activation of Ferroptosis in Target Tumor Cells through a Photothermally Responsive Iron‐Chelated Biopolymer Nanoplatform

Xue, Chencheng; Li, Menghuan; Liu, Changhuang; Li, Yanan; Yang, Fei; Hu, Yan; Cai, Kaiyong; Zhao, Yanli; Luo, Zhong

doi:10.1002/anie.202016872

Cited by 125 publications

(93 citation statements)

References 58 publications

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“…As a cytosolic flavinase, NQO1 can easily reduce the recognition group of quinone and its derivatives, thereby leading to intramolecular lactonization to form hydroquinone compounds 90 . Notably, NQO1 has shown high selectivity and sensitivity to quinones ( Figure 3 E ) 91 .…”

Section: Peptide/group Selective To Enzymesmentioning

confidence: 99%

Activated molecular probes for enzyme recognition and detection

Yuan¹,

Wu²,

Zhao³

et al. 2022

Theranostics

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Exploring and understanding the interaction of changes in the activities of various enzymes, such as proteases, phosphatases, and oxidoreductases with tumor invasion, proliferation, and metastasis is of great significance for early cancer diagnosis. To detect the activity of tumor-related enzymes, various molecular probes have been developed with different imaging methods, including optical imaging, photoacoustic imaging (PAI), magnetic resonance imaging, positron emission tomography, and so on. In this review, we first describe the biological functions of various enzymes and the selectively recognized chemical linkers or groups. Subsequently, we systematically summarize the design mechanism of imaging probes and different imaging methods. Finally, we explore the challenges and development prospects in the field of enzyme activity detection. This comprehensive review will provide more insight into the design and development of enzyme activated molecular probes.

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Section: Peptide/group Selective To Enzymesmentioning

confidence: 99%

Activated molecular probes for enzyme recognition and detection

Yuan¹,

Wu²,

Zhao³

et al. 2022

Theranostics

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show abstract

“…Apart from the above genetic solutions, endogenic active radicals such as lipid peroxides (LPO) and ROS are generally recognized to devitalize HSPs with high efficiency. A newly discovered cell death form ferroptosis is characterized by disruption of cellular redox homeostasis and excessive generation of LPO and ROS [53] . The LPO could spontaneously form aldehyde degradation products, which crosslink primary amines of proteins to destruct their structure and function.…”

Section: Nanomedicine-potentiated Strategies For Enhancing Single-mode Mpttmentioning

confidence: 99%

Nanomedicine potentiates mild photothermal therapy for tumor ablation

Jiang

Cheng

et al. 2021

Asian Journal of Pharmaceutical Sciences

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The booming photothermal therapy (PTT) has achieved great progress in non-invasive oncotherapy, and paves a novel way for clinical oncotherapy. Of note, mild temperature PTT (mPTT) of 42–45 °C could avoid treatment bottleneck of the traditional PTT, including nonspecific injury to normal tissues, vasculature and host antitumor immunity. However, cancer cells can resist mPTT via heat shock response and autophagy, thus leading to insufficient mPTT monotherapy to ablate tumor. To overcome the deficient antitumor efficacy caused by thermo-resistance of cancer cells and mono mPTT, synergistic therapies towards cancer cells have been conducted with mPTT. This review summarizes the recent advances in nanomedicine-potentiated mPTT for cancer treatment, including strategies for enhanced single-mode mPTT and mPTT plus synergistic therapies. Moreover, challenges and prospects for clinical translation of nanomedicine-potentiated mPTT are discussed.

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“…[77] Since ferroptosis has been described as an autophagic cell death process, nanodrug based on the autophagy-associated ferroptosis mechanism may exhibit more robust ferroptosis-inducing capability. [78] For example, the ultrasmall iron oxide nanoparticles (USIONPs) are a class of clinically approved nanoagent, which could significantly induce the intracellular iron abundance to elevate ROS and lipid ROS levels in glioblastoma (GBM) cells. [79] Further research has demonstrated that inhibition of autophagy by shRNA knock-down of Beclin1/ATG5 could significantly suppress the USIONPs-induced ferroptosis, whereas overexpression of ATG5/Beclin1 could enhance the USIONP-induced ferroptosis.…”

Section: Nanoparticulate Inducersmentioning

confidence: 99%

Autophagy‐Dependent Ferroptosis as a Therapeutic Target in Cancer

Liu

et al. 2021

ChemMedChem

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Ferroptosis is an iron-dependent form of cell death associated with the accumulation of labile iron and cytotoxic lipid peroxides. Increasing evidence reveals that ferroptosis is not a self-standing phenomenon and has close connections with other cellular events. Remarkably, recent insights show that ferroptosis is dependent on autophagy, which is a lysosomal degradation pathway responsible for the recycling of damaged cellular components under survival stress. Autophagy is capable of contributing to ferroptosis through degradation of the ferritin, an iron-storage protein, accompanied with the accumulation of iron levels and lipid ROS. The interplay between autophagy and ferroptosis also reveals emerging opportunities for novel tumor therapies, which has inspired the development of many treatment strategies capable of inducing ferroptosis in tumor cells via autophagic pathways based on molecular and nanoparticulate agents. In this review, we summarize the specific molecular and regulatory networks of autophagydependent ferroptosis and highlight their pathophysiological impact on various aspects of tumor cells. A perspective was also provided regarding the preliminary therapeutic exploitation of ferroptosis/autophagy crosstalk for tumor treatment.

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NIR‐Actuated Remote Activation of Ferroptosis in Target Tumor Cells through a Photothermally Responsive Iron‐Chelated Biopolymer Nanoplatform

Cited by 125 publications

References 58 publications

Activated molecular probes for enzyme recognition and detection

Activated molecular probes for enzyme recognition and detection

Nanomedicine potentiates mild photothermal therapy for tumor ablation

Autophagy‐Dependent Ferroptosis as a Therapeutic Target in Cancer

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