NIR-Activated Thermosensitive Liposome–Gold Nanorod Hybrids for Enhanced Drug Delivery and Stimulus Sensitivity

Abstract

Combinatorial photothermal therapy and chemotherapy is an extremely promising tumor therapeutic modality. However, such systems still remain challenges in stimulus sensitivity, avoiding drug leakage, and therapeutic safety. To solve these problems, we engineered actively loaded doxorubicin (DOX) and gold nanorod (GNR) liposomes through embedding stiff hollow mesoporous silica nanoparticles (HMSNs) in the liposomal water cavity (HMLGDB) to resist the influence of shear force of GNRs to prevent drug leakage. Under 808 nm laser irradiation, the ambient temperature was raised greatly because of the photothermal conversion of GNRs, thereby rupturing the lipid layer and then triggering the DOX release. The results of in vitro experiments showed that the low concentration of HMLGDB (15 μg/mL) could effectively overcome the MCF-7 cells (human breast cancer cell line) by the increase of DOX concentration intracellularly and the good photothermal effect of GNRs. After intravenous injection, HMLGDB exhibited intratumor aggregation and PTT capacity. Furthermore, the combined chemo−photothermal antitumor strategy demonstrated a high inhibition of tumor growth and low damage to normal tissues. The developed hybrids provide a paradigm for efficient combinatorial photothermal therapy (PTT) and chemotherapy (CT).

Amplification of Oxygen-Independent Free Radicals Based on a Glutathione Depletion and Biosynthesis Inhibition Strategy for Photothermal and Thermodynamic Therapy of Hypoxic Tumors

“…The fabrication process of GZABEF NPs is illustrated in Scheme a. First, GNRs absorbing in NIR-II were prepared by seed-mediated methods . The scanning electron microscopy (SEM) image revealed that the GNRs were 10 nm by 85 nm (aspect ratio = 8.5) (Figure a).…”

“…First, GNRs absorbing in NIR-II were prepared by seedmediated methods. 18 The scanning electron microscopy (SEM) image revealed that the GNRs were 10 nm by 85 nm (aspect ratio = 8.5) (Figure 1a). According to the UV−vis spectra, the longitudinal surface plasmon band was located at 1060 nm (Figure S1).…”

Erythrocyte–Cancer Hybrid Membrane-Camouflaged Prussian Blue Nanoparticles with Enhanced Photothermal Therapy in Tumors

“…Nanoparticles need to overcome multiple barriers to accumulate in target tissues via blood circulation. The recognition and clearance mechanisms of the endothelial phagocytic system and the targeting ability of the nanoparticles are two of the most critical factors . Biomimetic modification of nanoparticles by using erythrocyte membranes where the CD47 membrane protein on the surface can establish self-recognition communication with the phagocytic system and evade recognition, phagocytosis, and clearance, thus enhancing the long cycling capacity of the nanoparticles .…”

“…Based on the development of nanotechnology, nanoplatform provides a perfect loading and transport platform for targeted delivery and intelligent release of drugs such as small molecules, genes, peptides, inorganic materials, and therapeutic gases, which can effectively increase the targeted accumulation efficiency, improve pharmacokinetic properties, and reduce toxic effects of drugs. − Gentle and noninvasive treatments have attracted a lot of attention due to their effective tumor-destroying ability and minimal harm to normal tissues . Photothermal therapy (PTT) has become an important research direction in anti-tumor research because of its safety, efficiency, and on-demand modifiability. − …”

Indocyanine Green‐Glycogen Conjugates for Near‐Infrared‐Triggered Photothermal Cancer Therapy

“…[4,5] The development of photothermal therapy has been accelerated by significant research on NIR-sensitive photothermal agents, including organic small molecule dyes, conjugated polymers, and metallic plasmonic nanoparticles (e.g., gold nanorods and quantum dots). [6][7][8][9][10][11][12][13][14] These photosensitive materials are able to undergo photoexcitation, resulting in the production of thermal energy via the photothermal effect. [15,16] Among those NIR-sensitive reagents, small molecule organic dyes have attracted significant interest because of their low toxicity, excellent biocompatibility, and tunable spectral properties through structural modifications.…”