NIR absorbing reduced graphene oxide for photothermal radiotherapy for treatment of esophageal cancer

Gai, L.-X.; Wang, Weiqing; Wu, Xia; Su, Xiujun; Yang, Fu-Cun

doi:10.1016/j.jphotobiol.2019.03.014

Cited by 27 publications

(6 citation statements)

References 35 publications

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“…The compounds 26, 5h, 5i, and 5k were then characterised in a panel of EAC cell lines (Table 3) [57][58][59]. As a first step, an MTT viability assay was performed to investigate the effects of the compounds on the viability of OE-33 cells at 72 h. As evidenced in Table 3, 26 and 5i…”

Section: Effect Of Selected Compounds On Human Esophageal Adenocarcin...mentioning

confidence: 99%

Design and synthesis of multifunctional microtubule targeting agents endowed with dual pro-apoptotic and anti-autophagic efficacy

Campiani¹,

Khan²,

Ulivieri³

et al. 2022

European Journal of Medicinal Chemistry

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Section: Effect Of Selected Compounds On Human Esophageal Adenocarcin...mentioning

confidence: 99%

Design and synthesis of multifunctional microtubule targeting agents endowed with dual pro-apoptotic and anti-autophagic efficacy

Campiani¹,

Khan²,

Ulivieri³

et al. 2022

European Journal of Medicinal Chemistry

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“…However, a proper level of hyperthermia could improve oxygen levels in the tumor microenvironment by increasing intratumoral bloodstream thereby sensitize cells to RT [ 82 , 83 ]. Therefore, it has been reported that combining PTT with RT can improve the therapeutic outcome of tumors [ 84 , 85 ]. Thus, hybrid nanocomposites were developed by combining radio therapeutic agents and PANI for radiophotothermal therapy [ 59 , 60 ].…”

Section: Pani-based Biomaterials For Tumor Ablationmentioning

confidence: 99%

Recent Advances of Polyaniline-Based Biomaterials for Phototherapeutic Treatments of Tumors and Bacterial Infections

et al. 2020

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Conventional treatments fail to completely eradicate tumor or bacterial infections due to their inherent shortcomings. In recent years, photothermal therapy (PTT) has emerged as an attractive treatment modality that relies on the absorption of photothermal agents (PTAs) at a specific wavelength, thereby transforming the excitation light energy into heat. The advantages of PTT are its high efficacy, specificity, and minimal damage to normal tissues. To this end, various inorganic nanomaterials such as gold nanostructures, carbon nanostructures, and transition metal dichalcogenides have been extensively explored for PTT applications. Subsequently, the focus has shifted to the development of polymeric PTAs, owing to their unique properties such as biodegradability, biocompatibility, non-immunogenicity, and low toxicity when compared to inorganic PTAs. Among various organic PTAs, polyaniline (PANI) is one of the best-known and earliest-reported organic PTAs. Hence, in this review, we cover the recent advances and progress of PANI-based biomaterials for PTT application in tumors and bacterial infections. The future prospects in this exciting area are also addressed.

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“…GO has been used in studies with prostate cancer [ 22 ], glioma [ 23 ], lung cancer [ 24 ], and esophageal cancer [ 25 ]. Additionally, it can be used as a carrier for drugs such as doxorubicin (DOX) [ 26 ], 5-fluorouracil [ 27 ], docetaxel [ 28 ], among other chemotherapies.…”

Section: Introductionmentioning

confidence: 99%

Graphene and its derivatives: understanding the main chemical and medicinal chemistry roles for biomedical applications

et al. 2021

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Graphic abstract Over the past few years, there has been a growing potential use of graphene and its derivatives in several biomedical areas, such as drug delivery systems, biosensors, and imaging systems, especially for having excellent optical, electronic, thermal, and mechanical properties. Therefore, nanomaterials in the graphene family have shown promising results in several areas of science. The different physicochemical properties of graphene and its derivatives guide its biocompatibility and toxicity. Hence, further studies to explain the interactions of these nanomaterials with biological systems are fundamental. This review has shown the applicability of the graphene family in several biomedical modalities, with particular attention for cancer therapy and diagnosis, as a potent theranostic. This ability is derivative from the considerable number of forms that the graphene family can assume. The graphene-based materials biodistribution profile, clearance, toxicity, and cytotoxicity, interacting with biological systems, are discussed here, focusing on its synthesis methodology, physicochemical properties, and production quality. Despite the growing increase in the bioavailability and toxicity studies of graphene and its derivatives, there is still much to be unveiled to develop safe and effective formulations.

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NIR absorbing reduced graphene oxide for photothermal radiotherapy for treatment of esophageal cancer

Cited by 27 publications

References 35 publications

Design and synthesis of multifunctional microtubule targeting agents endowed with dual pro-apoptotic and anti-autophagic efficacy

Design and synthesis of multifunctional microtubule targeting agents endowed with dual pro-apoptotic and anti-autophagic efficacy

Recent Advances of Polyaniline-Based Biomaterials for Phototherapeutic Treatments of Tumors and Bacterial Infections

Graphene and its derivatives: understanding the main chemical and medicinal chemistry roles for biomedical applications

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