Nipah Virus Infection in Bats (Order Chiroptera) in Peninsular Malaysia

Yob, Johara Mohd; Field, Hume; Rashdi, Azmin Mohd; Morrissy, Chris; Heide, Brenda van der; Rota, Paul A.; Adzhar, A.; White, John R.; Daniels, Peter; Jamaluddin, Aziz; Ksiazek, Thomas G.

doi:10.3201/eid0703.017312

Cited by 425 publications

(103 citation statements)

References 9 publications

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“…Yob et al [101] and Chua [12] have confirmed that fruit bats (popularly known as flying foxes) found in Malaysia, P. vampyrus and P. hypomelanus, are the natural reservoir hosts of NiV. The virus is assumed to have been introduced into the swine population from bat species of Pteropus.…”

Section: The Host Rangementioning

confidence: 95%

Nipah virus infection: current scenario

et al. 2013

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Section: The Host Rangementioning

confidence: 95%

Nipah virus infection: current scenario

et al. 2013

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“…The grey-headed flying fox (Pteropus poliocephalus) and the black flying-fox (Pteropus alecto), both Pteropus spp. occurring in Malaysia were found seropositive for NiV [30]. Neutralizing antibodies, and the virus has been isolated from the small flying fox or variable flying fox (Pteropus hypomelanus) and the large flying fox (Pteropus vampyrus) [30][31][32].…”

Section: Species Susceptible To Nivmentioning

confidence: 99%

“…occurring in Malaysia were found seropositive for NiV [30]. Neutralizing antibodies, and the virus has been isolated from the small flying fox or variable flying fox (Pteropus hypomelanus) and the large flying fox (Pteropus vampyrus) [30][31][32]. NiV has been isolated from urine of Lyle's flying fox (Pteropus lylei) in Cambodia [33].…”

Section: Species Susceptible To Nivmentioning

confidence: 99%

“…Serological evidences indicate that circulation of henipaviruses in bats is not limited to species belonging to the genus Pteropus, but also extended to a wider range of both frugivorous and insectivorous bats [30,34,35]. An example is represented by the Lesser Asiatic yellow house bat (Scotophilus kuhlii) (wingspan up to 5.2 cm, weight up to 22 gr), insectivorous bat (Microchiroptera) of the genus Scotophilus (yellow bats), family Vespertilionidae, diffuse in Bangladesh, India, Indonesia, Malaysia, Pakistan, Philippines, Sri Lanka, and Taiwan, reported as Nipah virus carrier [30].…”

Section: Species Susceptible To Nivmentioning

confidence: 99%

“…An example is represented by the Lesser Asiatic yellow house bat (Scotophilus kuhlii) (wingspan up to 5.2 cm, weight up to 22 gr), insectivorous bat (Microchiroptera) of the genus Scotophilus (yellow bats), family Vespertilionidae, diffuse in Bangladesh, India, Indonesia, Malaysia, Pakistan, Philippines, Sri Lanka, and Taiwan, reported as Nipah virus carrier [30]. Furthermore, in China, the prevalence of antiNiV or closely related virus antibodies was especially prominent among Daubenton's bat (Myotis daubentoni) and Rickett's big-footed bat (MYOTIS ricketti), two species of insectivorous bats of the genus Myotis, family Vespertilionidae [35].…”

Section: Species Susceptible To Nivmentioning

confidence: 99%

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Nipah Virus

Giangaspero¹

2013

Trop Med Surg

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Natural HostFruit bats (Macrochiroptera) of the family Pteropodidaeparticularly species belonging to the Pteropus genus-are the natural hosts for Nipah virus. There is no apparent disease in fruit bats. Bats belonging to the genus Pteropus are widely distributed. They live in the tropics and subtropics of Asia, including the Indian subcontinent, Australia, Indonesia, Madagascar, and a number of remote oceanic islands in both the Indian and Pacific Oceans.Among the genus Pteropus, the Indian Flying Fox (Pteropus giganteus) (wingspan 1.5 m and up to 1.2 kg) and the relatively smaller Greater short-nosed fruit bat or Short-nosed Indian fruit bat (Cynopterus sphinx) (wingspan 48 cm), widespread and very common AbstractNipah virus is an emerging zoonosis with the potential to cause significant morbidity and mortality in humans and major economic and public health impacts. According to World Organisation for Animal Health (Office International des Épizooties: OIE), Nipah virus is a notifiable disease of importance to international trade.

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H enipaviruses

Aljofan

2015

Encyclopedia of Life Sciences

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Henipaviruses are the deadliest human pathogens of the Paramyxoviridae family. The genus Henipavirus includes two closely related, zoonotic, and highly pathogenic paramyxoviruses, Nipah virus (NiV) and Hendra virus (HeV), which cause high morbidity and mortality in animals and humans. There are no approved therapeutics to treat or prevent henipavirus infections in humans. The bat species Pteropus are the natural reservoir of henipaviruses, and zoonotic transmission can occur directly or through an intermediate host; horses for HeV and pigs for NiV. The unavailability of a treatment for these infections, the recent detection of HeV antibodies in family pets and the emergence of NiV infections in new geographic areas (Philippines) are an illustration of the risk that these viruses possess and their momentum of becoming a global threat. Unless an effective therapeutic against these viruses is developed, they will continue to emerge and cause significant challenges and threats in the coming years. Key Concepts The newly established genus Henipavirus of Paramyxoviridae family has three members Hendra, Nipah and Cedar viruses. Fruit bats of the genus Pteropus have been identified as the natural reservoir for henipaviruses. Both Nipah and Hendra viruses are highly pathogenic agents that cause acute encephalitis and respiratory illness with high mortality rate in humans, pigs and horses. There is no approved therapeutics for the treatment of henipaviruses, and they continue to pose a threat in Australia (Hendra virus) and East and Southeast Asia (Nipah virus) with a great potential to spread beyond these regions. M 102.4 is an experimental monoclonal antibody that targets the viral entry stage of Henipavirus and was proven to treat henipavirus infections in animals.

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Nipah Virus Infection in Bats (Order Chiroptera) in Peninsular Malaysia

Cited by 425 publications

References 9 publications

Nipah virus infection: current scenario

Nipah virus infection: current scenario

Nipah Virus

H enipaviruses

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