Nipah Virus Contamination of Hospital Surfaces during Outbreaks, Bangladesh, 2013–2014

Hassan, Zakiul; Sazzad, Hossain M.S.; Luby, Stephen P.; Sturm‐Ramirez, Katharine; Bhuiyan, Mejbah; Rahman, Mohammed Ziaur; Islam, M. Saiful; Ströher, Ute; Sultana, Sharmin; Kafi, Mohammad Abdullah Heel; Daszak, Peter; Rahman, Mahmudur; Gurley, Emily S.

doi:10.3201/eid2401.161758

Cited by 49 publications

(35 citation statements)

References 38 publications

(59 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In humans, severe acute respiratory sickness and/ or encephalitis can be provoked by a bat-borne zoonotic, paramyxoviral pathogen NiV. 13,14 This negative-sense single-stranded RNA virus belongs to the family Paramyxoviridae, genus Henipavirus and is closely related to Hendra viruses. 13,15 Like Hendra virus, NiV may also cause fatal pneumonia or an acute respiratory-distress-like syndrome.…”

Section: Cellular and Molecular Changes In Niv Infectionmentioning

confidence: 99%

Nano-based approach to combat emerging viral (NIPAH virus) infection

Kerry

Malik

Redda

et al. 2019

Nanomedicine: Nanotechnology, Biology and Medicine

108

107

View full text Add to dashboard Cite

Emergence of new virus and their heterogeneity are growing at an alarming rate. Sudden outburst of Nipah virus (NiV) has raised serious question about their instant management using conventional medication and diagnostic measures. A coherent strategy with versatility and comprehensive perspective to confront the rising distress could perhaps be effectuated by implementation of nanotechnology. But in concurrent to resourceful and precise execution of nano-based medication, there is an ultimate need of concrete understanding of the NIV pathogenesis. Moreover, to amplify the effectiveness of nano-based approach in a conquest against NiV, a list of developed nanosystem with antiviral activity is also a prerequisite. Therefore the present review provides a meticulous cognizance of cellular and molecular pathogenesis of NiV. Conventional as well several nano-based diagnosis experimentations against viruses have been discussed. Lastly, potential efficacy of different forms of nano-based systems as convenient means to shield mankind against NiV has also been introduced.

show abstract

Section: Cellular and Molecular Changes In Niv Infectionmentioning

confidence: 99%

Nano-based approach to combat emerging viral (NIPAH virus) infection

Kerry

Malik

Redda

et al. 2019

Nanomedicine: Nanotechnology, Biology and Medicine

108

107

View full text Add to dashboard Cite

show abstract

“…Evidence indicated that human-to-human transmission resulted from direct contact with respiratory secretions of severely ill patients 39–42. NiV can persist on surfaces, posing further risk for fomite-borne NiV transmission 43…”

Section: Introductionmentioning

confidence: 99%

Diagnostics for Nipah virus: a zoonotic pathogen endemic to Southeast Asia

Mazzola

Kelly-Cirino

2019

BMJ Glob Health

View full text Add to dashboard Cite

Nipah virus (NiV) is an emerging pathogen that, unlike other priority pathogens identified by WHO, is endemic to Southeast Asia. It is most commonly transmitted through exposure to saliva or excrement from the Pteropus fruit bat, or direct contact with intermediate animal hosts, such as pigs. NiV infection causes severe febrile encephalitic disease and/or respiratory disease; treatment options are limited to supportive care. A number of in-house diagnostic assays for NiV using serological and nucleic acid amplification techniques have been developed for NiV and are used in laboratory settings, including some early multiplex panels for differentiation of NiV infection from other febrile diseases. However, given the often rural and remote nature of NiV outbreak settings, there remains a need for rapid diagnostic tests that can be implemented at the point of care. Additionally, more reliable assays for surveillance of communities and livestock will be vital to achieving a better understanding of the ecology of the fruit bat host and transmission risk to other intermediate hosts, enabling implementation of a ‘One Health’ approach to outbreak prevention and the management of this zoonotic disease. An improved understanding of NiV viral diversity and infection kinetics or dynamics will be central to the development of new diagnostics, and access to clinical specimens must be improved to enable effective validation and external quality assessments. Target product profiles for NiV diagnostics should be refined to take into account these outstanding needs.

show abstract

“…Nipah virus was first discovered in a large encephalitis outbreak in Malaysia in 1998 [2][3][4]. Nipah virus outbreak has been recognized nearly every year in Bangladesh since 2001 and occasionally in neighboring India [5][6][7][8][9]. With the capacity of person-to-person transmission, high case fatality rate (>70%) and no availability of treatment or vaccine, the World Health Organization included the Nipah virus among the 7 Blueprint list of priority diseases and effort for Nipah vaccine development is underway [10-12].…”

Section: Introductionmentioning

confidence: 99%

Genomic profiling of Nipah virus using NGS driven RNA-Seq expression data

et al. 2019

View full text Add to dashboard Cite

Nipah virus (NiV) is an ssRNA, enveloped paramyxovirus in the genus Henipaveridae with a case fatality rate >70%. We analyzed the NGS RNA-Seq gene expression data of NiV to detect differentially expressed genes (DEGs) using the statistical R package limma. We used the Cytoscape, Ensembl, and STRING tools to construct the gene-gene interaction tree, phylogenetic gene tree and protein-protein interaction networks towards functional annotation. We identified 2707 DEGs (p-value <0.05) among 54359 NiV genes. The top-up and down-regulated DEGs were EPST1, MX1, IFIT3, RSAD2, OAS1, OASL, CMPK2 and SLFN13, SPAC977.17 using log2FC criteria with optimum threshold 1.0. The top 20 up-regulated gene-gene interaction trees showed no significant association between Nipah and Tularemia virus. Similarly, the top 20 down-regulated genes of neither Ebola nor Tularemia virus showed an association with the Nipah virus. Hence, we document the top-up and down-regulated DEGs for further consideration as biomarkers and candidates for vaccine or drug design against Nipah virus to combat infection.

show abstract

Nipah Virus Contamination of Hospital Surfaces during Outbreaks, Bangladesh, 2013–2014

Cited by 49 publications

References 38 publications

Nano-based approach to combat emerging viral (NIPAH virus) infection

Nano-based approach to combat emerging viral (NIPAH virus) infection

Diagnostics for Nipah virus: a zoonotic pathogen endemic to Southeast Asia

Genomic profiling of Nipah virus using NGS driven RNA-Seq expression data

Contact Info

Product

Resources

About