Niosomes loaded with diclofenac for transdermal administration: Physico-chemical characterization, ex vivo and in vivo skin permeation studies

Hai, Tran Yen Thi; Ngoc, Tran Giang; Lan, Hoang Anh; Vu, Thi Thu Giang

doi:10.7324/japs.2020.101207

Cited by 3 publications

(3 citation statements)

References 23 publications

(14 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This approach advantage lies in avoiding first-pass metabolism but it suffers from slow drug absorption through the skin. 27,32 Researchers conduct an experiment by Tran, et al 33 that niosomes containing diclofenac produced through ethanol injection, exhibited a spherical shape with a small diameter of approximately 100 nm and a limited distribution. Ex-vivo and in-vivo studies indicated that the diclofenac niosomes hydrogel enhanced both the quantity and speed of diclofenac transport through the skin along with its concentration in the muscle, surpassing that of the commercial medication.…”

Section: Dermal and Transdermal Drug Deliverymentioning

confidence: 99%

“…These results underscore the potential application of diclofenac niosomes in transdermal drug administration. 33 3.4 Oral drug delivery: Drug are administered through this method to address challenges associated with issues such as susceptibility to stomach acids and digestive enzymes, inadequate absorption and fluctuating medication bioavailability. Consequently, novel drug delivery mechanisms such as niosomes have been employed to enhance drug bioavailability.…”

Section: Dermal and Transdermal Drug Deliverymentioning

confidence: 99%

See 1 more Smart Citation

A Comprehensive Review on Niosomes in Drug Delivery and Recent Advancements

Teron,

Bhuyan,

Saikia

et al. 2024

J. Drug Delivery Ther.

View full text Add to dashboard Cite

The recent emphasis on nanocarrier development for drug delivery stems from the need to target specific diseased areas while sparing healthy tissues. Effective and safe drug administration has long posed challenges in medicine. Over the past decade, the emergence of vesicles as a means to enhance drug delivery has captivated researchers in the field of drug delivery systems. Among vesicular systems, niosomes have gained attention due to their nonionic features. Unlike liposomes, niosomes offer superior stability, making them a preferred choice. Non-ionic in nature niosomes offer unique advantages in drug delivery providing a versatile platform for encapsulating various drugs to enhance bioavailability and ensure controlled release. Understanding preparation techniques enables tailored applications from oral to transdermal delivery. Characterization methods such as morphology and particles size are pivotal in ensuring the stability and effectiveness of niosomes. Applications span cancer therapy, diagnostic imaging, and vaccination adjuvants, showcasing niosomes versatility. Ongoing research reflects dynamic efforts to enhance capabilities, emphasizing their pivotal role in evolving drug delivery systems. In this comprehensive review, we aim to encapsulate fundamental aspects of niosomes, encompassing diverse preparation methods, various niosomal types, methods for characterization and the advancements witnessed in niosomal research over the past decade, drawing insights from a literature review. Keywords: Niosomes, Drug delivery, Nanocarrier, Vesicles, Nanomedicines

show abstract

Section: Dermal and Transdermal Drug Deliverymentioning

confidence: 99%

Section: Dermal and Transdermal Drug Deliverymentioning

confidence: 99%

A Comprehensive Review on Niosomes in Drug Delivery and Recent Advancements

Teron,

Bhuyan,

Saikia

et al. 2024

J. Drug Delivery Ther.

View full text Add to dashboard Cite

show abstract

“…But its high lipophilicity and very poor water solubility can hinder the permeation through the skin [6] . Hence permeability can be improved by incorporation of LRTD into colloidal drug carrier systems, and niosomes can be proposed for that as it is proven by the researchers that it enhances the transdermal penetration [7] .…”

mentioning

confidence: 99%

Formulation and In Vitro Evaluation of Niosomal Gel of Loratadine: A Novel Topical Agent for Allergic Skin

Bhattacharyya¹,

Mohan²

2022

IJPS

View full text Add to dashboard Cite

Loratadine is an efficacious, non-drowsy antihistaminic molecule prescribed for allergic skin. The conventional oral dosage form is associated with various side effects, limited and variable absorption. The present study attempts to improve the effectiveness of the drug by formulating a niosome loaded hydrogel of loratadine for treating allergic skin. Ether injection method was used to prepare the niosomes of loratadine using Box Behnken design. Particle size analysis, surface charge, surface morphology (atomic force microscopy), compatibility (Fourier transform infrared spectroscopy), thermal (differential scanning calorimetry), and surface characteristics (powder X-ray diffraction) study were done to evaluate the drug-loaded niosomes. The optimized formulation was incorporated into two types of gelling systems. The nanogels were evaluated for rheological and mechanical properties, in vitro, ex vivo permeation and skin irritation studies. The Box Behnken design was found to be productive for the formulation of nano-sized (109.99 nm) and stable -37.5 mV niosomes of loratadine. The atomic force microscopy study revealed the formation of unilamellar niosomes, no incompatibility was detected between drug and excipients through Fourier transform infrared spectroscopy study. The differential scanning calorimetry and powder X-ray diffraction study reported the confinement of drugs in the niosomal core. The nanogels had good rheological and mechanical properties. The ex vivo study revealed the maximum penetration of the drug from the gel base of Xanthan gum, and no skin irritation was reported from the nanogel. The formulation and evaluation of niosomal gel of loratadine were found to have satisfactory permeation and can be a promising alternative approach for the administration of loratadine in the treatment of skin allergy.

show abstract

Formulation and characterisation of lacidipine niosomal gel for transdermal delivery

Mapari¹,

DCruz²,

Kumar

et al. 2023

Tenside Surfactants Detergents

View full text Add to dashboard Cite

The present study aimed to enhance the transdermal delivery of lacidipine by niosomal vesicles. Lacidipine niosomes were generated using the ultrasonic method, and Span 60 was used as a nonionic surfactant. Formulations were prepared containing Span 60 and cholesterol in 1:1 and 2:1 ratios, respectively, with essential oils added at increasing concentrations. The formulated niosomes had nano-vesicles with entrapment efficiency ranging from 75.81% to 91.25% and in-vitro drug release ranging from 80.61% to 89.81%. The optimal formulation was selected based on particle size, entrapment efficiency and in-vitro drug release. Optical microscopy and high-resolution transmission electron microscopy studies revealed a spherical shape of the niosomal vesicles. Fourier transform infrared spectroscopy, differential scanning calorimetry and X-ray diffraction studies confirmed complete encapsulation of the drug in the niosomal vesicles. The optimized formulation was also incorporated into a gel base, which was then evaluated for appearance, pH, viscosity, spreadability, in vitro drug release and stability. Overall, the results indicated that the developed niosomal lacidipine vesicles may provide an alternative to existing delivery systems for this drug.

show abstract

Niosomes loaded with diclofenac for transdermal administration: Physico-chemical characterization, ex vivo and in vivo skin permeation studies

Cited by 3 publications

References 23 publications

A Comprehensive Review on Niosomes in Drug Delivery and Recent Advancements

A Comprehensive Review on Niosomes in Drug Delivery and Recent Advancements

Formulation and In Vitro Evaluation of Niosomal Gel of Loratadine: A Novel Topical Agent for Allergic Skin

Formulation and characterisation of lacidipine niosomal gel for transdermal delivery

Contact Info

Product

Resources

About