Niosomes in Malaria

Patel, Geeta K.; Prajapati, Bhupendra G.; Pathak, Yashawant

doi:10.1007/978-3-031-15848-3_12

Cited by 1 publication

(1 citation statement)

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“…Traditional techniques utilized in the synthesis of gold nanoparticles (AuNPs) frequently entail the utilization of hazardous substances and costly methodologies, thereby accentuating environmental hazards and impending its clinical application despite its captivating attributes [14]. Hence, the exploration of a straightforward, environmentally friendly and economically viable approach becomes a signi cant imperative.…”

Section: Introductionmentioning

confidence: 99%

Bio-synthesis of gold nanoparticles from Codariocalyx motorius leaf extract: Physiochemical evaluation, antimicrobial, antioxidant and anticancer activity against Hep G2 cell lines

Deivanathan,

Dayana,

Prakash

2023

Preprint

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This research delved into the synthesis of gold nanoparticles (AuNPs) utilizing leaf extract derived from Codariocalyx motorius (C.motorius). The confirmation of C.motorius gold nanoparticles (CM-AuNPs) formation was established through the visual observation of color changes in the colloidal solution. A comprehensive characterization of CM-AuNPs employed UV-vis spectroscopy, FT-IR, FE-SEM, EDAX, XRD, HR-TEM, DLZ and Zeta potential. The UV- vis spectrum exhibited a distinctive peak at 534 nm, indicative of CM-AuNPs. The FT-IR spectrum identified the presence of -OH and -NH functional groups intricately associated with the AuNPs. HR-SEM analysis revealed average size of approximately 44 nm for the CM-AuNPs. XRD confirmed the face-centered cubic crystallinity of CM-AuNPs. In the DPPH assay, the bio-synthesized CM-AuNPs demonstrated robust antioxidant activity, displaying an IC50 of 61.27%. Moreover, the bio-synthesized CM-AuNPs exhibited significant antibacterial efficacy against both gram-positive (Staphylococcus aureus) and gram-negative (Escherichia coli) bacteria. Inhibition values for these bacteria were recorded at 6 ± 2.94392 mm and 5 ± 2.58199 mm respectively. Further, the bio-synthesized AuNPs showcased antiproliferative activity against Hep G2 cells, with an IC50 value 6.89 µg/mL. These compelling findings underscore the potential applications of CM-AuNPs, synthesized from C.motorius leaf extract in the realm of medication delivery.

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Section: Introductionmentioning

confidence: 99%