Niosomes as carriers for tretinoin II. Influence of vesicular incorporation on tretinoin photostability

Manconi, Maria; Valenti, Donatella; Sinico, Chiara; Lai, Francesco; Loy, Giuseppe; Fadda, Anna Maria

doi:10.1016/s0378-5173(03)00268-0

Cited by 129 publications

(46 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…3). This observation is in contrast to earlier studies (Brisaert and Plaizier-Vercammen 2000;Manconi et al 2003;Ioele et al 2005), most likely to due to the different conditions present in relatively dermatological preparations.…”

Section: Determination Of Kinetic Parameters Of Photodegradationcontrasting

confidence: 99%

“…For 13RA, hydoxypropyl-β-cyclodextrin delays photodegradation and minimizes isomerization (Yap et al 2005) and inclusion of RA in liposomes has been reported to protect against photodegradation (Brisaert et al 2001). The chemical stability of RA in ethanol and niosomes under UV and artificial light conditions has been studied and incorporation of RA in niosomes led to reduce the rates of the photodegradation (Manconi et al 2003). The photodegradation process of RA and 13RA in ethanol and liposomes has been studied by UV spectrophotometry and RA was found to rapidly isomerizes in ethanol to 13 RA and 9RA with first-order kinetics (Ioele et al 2005).…”

Section: Introductionmentioning

confidence: 99%

“…The photodegradation process of RA and 13RA in ethanol and liposomes has been studied by UV spectrophotometry and RA was found to rapidly isomerizes in ethanol to 13 RA and 9RA with first-order kinetics (Ioele et al 2005). Other studies also have reported RA degradation to follow first-order kinetics (Brisaert and Plaizier-Vercammen 2000;Ioele et al 2005) while studies reporting degradation to follow zero-order kinetics have appeared (Manconi et al 2003).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

UVA is the major contributor to the photodegradation of tretinoin and isotretinoin: Implications for development of improved pharmaceutical formulations

Tashtoush

Jacobson

2008

International Journal of Pharmaceutics

View full text Add to dashboard Cite

The chemical stability of tretinoin (RA) and isotretinoin (13RA) in ethanol and dermatological cream preparations exposed to solar simulated light (SSL), UVA, and visible light has been studied. Photostability was monitored by an HPLC method that allowed simultaneous analysis of RA and 13RA, thus allowing photodegradation due to isomerization to other retinoids and photolysis to nonretinoid products to be monitored. Both retinoids undergo both isomerization and photolysis following SSL, UVA and visible light exposure but RA is more sensitive to photodegradation than 13RA. Degradation of both retinoids by photolysis is considerably greater in cream formulations than in ethanol and the photodegradation follows second order kinetics. Rate constants and half-lives for degradation of RA and 13RA in ethanol solution and cream preparations subjected to different light sources are reported. The UVA component of SSL is the major contributor to photodegradation. Since UVA penetrates deeply into skin, our results suggest that photodegradation of RA may contribute to the photosensitivity associated with RA therapy. Our studies suggest that development of improved formulations and the use of effective UVA sunscreens may reduce the side effects of RA therapy.

show abstract

Section: Determination Of Kinetic Parameters Of Photodegradationcontrasting

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

UVA is the major contributor to the photodegradation of tretinoin and isotretinoin: Implications for development of improved pharmaceutical formulations

Tashtoush

Jacobson

2008

International Journal of Pharmaceutics

View full text Add to dashboard Cite

show abstract

“…Incorporation of tretinoin in liposomes to overcome its problems has been studied by several researchers (Foong et al, 1990;Masini et al,1993;Patel et al, 2000;Brisaert et al, 2001;Sinico et al, 2005). It was previously found that liposomes can increase tretinoin concentration in the epidermis and dermis when compared to conventional cream or gel (Manconi et al, 2003). Encapsulation of tretinoin into liposomes protects it from photo degradation.…”

Section: Introductionmentioning

confidence: 99%

Tretinoin-loaded liposomal formulations: from lab to comparative clinical study in acne patients

et al. 2015

View full text Add to dashboard Cite

Topical tretinoin is the most commonly used retinoid for acne. However, its irritative potential on the applied area and the barrier properties of the stratum corneum limit its use. The objective of the present study was to formulate tretinoin liposomal gel to obtain a formula with lower skin irritation potential and greater clinical effect. A statistical 2 4 factorial design was adopted. Sixteen formulae prepared and were properly evaluated. A candidate formula (F13G) prepared with 0.025% tretinoin, phospholipid-cholesterol-dicetylphosphate (9:1:0.01) and incorporated in 1% carbopol gel was selected for skin irritation test. Clinical study was conducted on acne patients and compared to marketed product. All liposomes formulations were spherical in shape. The addition of cholesterol in the film hydration method significantly decreased the vesicle size, and increased the percentage of incorporation efficiency at (p50.05). The presence of dicetylphosphate significantly increased drug release but did not affect the percentage of incorporation efficiency and vesicle size. The results of the clinical study in acne patients revealed that F13G showed significantly higher efficacy when compared to marketed product (p50.05).

show abstract

“…This system provides multiple opportunities for the entrapment of hydrophilic drugs (by entrapment in aqueous compartment) as well as for lipophilic, amphiphilic and charged hydrophilic drugs (via association with vesicle bilayer by hydrostatic and/or electrostatic interactions; Sharma & Sharma, 1997;Honeywell & Bouwstra, 2005). Vesicles are composed of Phospholipids and non-ionic surfactants (Bouwstra & Hofland, 1994;Crommelin & Schreier, 1994), the extensive range of which can be used their formulation (Berner et al, 1995;Manconi et al, 2002Manconi et al, , 2003. Physicochemical characteristics of vesicles such as size, charge, thermodynamic phase, lamellarity and bilayer elasticity plays an important role in their behavior and eventually on their effectiveness as drug delivery system which are ultimately influenced by their composition.…”

Section: Vesicular Carriers In Drug Deliverymentioning

confidence: 99%

Ethosomes: versatile vesicular carriers for efficient transdermal delivery of therapeutic agents

Pandey¹,

Golhani²,

Shukla³

2014

Drug Delivery

View full text Add to dashboard Cite

Delivery across skin is attractive due to its easy accessibility. However, drug delivery across skin is still a challenge in biomedical sciences. Over the past few decades, various successful novel devices and techniques have emerged to optimize drug delivery across skin whose obstructing behavior constricts entry of most of the therapeutic agents. Inability of various conventional vesicular formulations, e.g. liposomes to pass through the tapered (430 nm) intercellular channels of stratum corneum, rendered invention of some lipid based vesicular carrier systems such as ethosomes which consist of phospholipid, ethanol and water. Ethosomes are noninvasive delivery carriers that enable drugs to reach the deep skin layers and/or the systemic circulation. In spite of their sophistication in conceptuality, they are exemplified by easiness in their preparation, safety and efficacy -a combination that can highly inflate their application. This review attempts to describe all aspects of ethosomes including roles and upshots of different excipients, various methods of preparation and characterizations, research reports on various drug deliveries, patent reports and future prospects.

show abstract

Niosomes as carriers for tretinoin II. Influence of vesicular incorporation on tretinoin photostability

Cited by 129 publications

References 18 publications

UVA is the major contributor to the photodegradation of tretinoin and isotretinoin: Implications for development of improved pharmaceutical formulations

UVA is the major contributor to the photodegradation of tretinoin and isotretinoin: Implications for development of improved pharmaceutical formulations

Tretinoin-loaded liposomal formulations: from lab to comparative clinical study in acne patients

Ethosomes: versatile vesicular carriers for efficient transdermal delivery of therapeutic agents

Contact Info

Product

Resources

About