Niosomal Nanocarriers for Enhanced Skin Delivery of Quercetin with Functions of Anti-Tyrosinase and Antioxidant

Lu, Banyi; Huang, Yanting; Chen, Zhongyun; Ye, Jingyi; Xu, Hongyu; Chen, Wenrong; Long, Xiao-ying

doi:10.3390/molecules24122322

Cited by 69 publications

(36 citation statements)

References 59 publications

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“…It has been reported that Tween 80 improves the solubility of poorly soluble compounds (drugs) for better oral administration [35]. Lu et al have shown that the solubility of quercetin does not change significantly in buffer solutions with different pH compared to its solubility in water [11]. The authors have found that the solubility of quercetin increases by the addition of surfactants, especially by the addition of 0.8% Tween 80.…”

Section: In Vitro Release Profile Of Quercetinmentioning

confidence: 99%

“…In the present study, the release of QUE from the CA/PEG/QUE fibrous mat was performed under model conditions using a procedure for quercetin release in the presence of Tween 80 [11]. The QUE release was carried out in acetate buffer/Tween 80 = 99.2/0.8 v/v.…”

Section: In Vitro Release Profile Of Quercetinmentioning

confidence: 99%

“…This biologically active compound exhibits remarkable antioxidant [3][4][5], anti-inflammatory [6], antibacterial [7,8], and anti-tumor [9] activities, and it possesses high anti-allergic activity [10]. However, quercetin is almost insoluble in water, sparingly soluble in gastrointestinal fluids, and it is metabolized by human intestinal bacteria [11,12]. For that reason, it is necessary to develop suitable carriers of quercetin capable to enhance its solubility in water, which will lead to enhanced bioavailability and thus to improved biological activity.…”

Section: Introductionmentioning

confidence: 99%

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Antioxidant and Antitumor Activities of Novel Quercetin-Loaded Electrospun Cellulose Acetate/Polyethylene Glycol Fibrous Materials

et al. 2020

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The aim of present study was to obtain novel fibrous materials based on cellulose derivative and polyethylene glycol loaded with natural biologically active compound quercetin by electrospinning. Several methods including scanning electron microscopy (SEM), IR spectroscopy, X-ray diffraction analysis (XRD), water contact angle measurements, differential scanning calorimetry (DSC), and UV-VIS spectroscopy were utilized to characterize the obtained materials. The incorporation of polyethylene glycol in the fibrous material resulted in increased hydrophilicity and burst release of quercetin from the fibers. Quercetin-containing fibrous mats exhibited high antioxidant activity as estimated by DPPH free radical scavenging method. In vitro tests with HeLa tumor cells and SH-4 melanoma skin cells were performed in order to determine the cytotoxicity of the novel materials. It was found that the fibrous CA/PEG/QUE materials exhibited high cytotoxic effect against both cell lines. Therefore, the novel polymeric materials containing quercetin are promising candidates for biomedical and pharmaceutical applications.

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Section: In Vitro Release Profile Of Quercetinmentioning

confidence: 99%

Section: In Vitro Release Profile Of Quercetinmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Antioxidant and Antitumor Activities of Novel Quercetin-Loaded Electrospun Cellulose Acetate/Polyethylene Glycol Fibrous Materials

et al. 2020

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“…Due to the unique structure, niosomes can be used to load and deliver hydrophilic and hydrophobic substances. Lu et al designed Span60-Rh40-based niosomes for loading flavonoids to improve the solubility, stability and penetration [ 177 ]. It was demonstrated that niosomes significantly improved the solubility and light stability of quercetin.…”

Section: Nanoformulations For Loading and Delivery Of Polyphenolsmentioning

confidence: 99%

Nanoformulations to Enhance the Bioavailability and Physiological Functions of Polyphenols

et al. 2020

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Polyphenols are micronutrients that are widely present in human daily diets. Numerous studies have demonstrated their potential as antioxidants and anti-inflammatory agents, and for cancer prevention, heart protection and the treatment of neurodegenerative diseases. However, due to their vulnerability to environmental conditions and low bioavailability, their application in the food and medical fields is greatly limited. Nanoformulations, as excellent drug delivery systems, can overcome these limitations and maximize the pharmacological effects of polyphenols. In this review, we summarize the biological activities of polyphenols, together with systems for their delivery, including phospholipid complexes, lipid-based nanoparticles, protein-based nanoparticles, niosomes, polymers, micelles, emulsions and metal nanoparticles. The application of polyphenol nanoparticles in food and medicine is also discussed. Although loading into nanoparticles solves the main limitation to application of polyphenolic compounds, there are some concerns about their toxicological safety after entry into the human body. It is therefore necessary to conduct toxicity studies and residue analysis on the carrier.

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“…One of the most popular whitening agents is quercetin, a natural flavonoid with antioxidant properties, which exhibits anti-tyrosinase activity. Lu et al [112] described "nanoquercetin" applied in cosmetic formulations, which improved water solubility and skin penetration ability of quercetin thanks to the use of niosomes. Quercetin was also loaded to NLCs, stabilized by Pluronic F68 and applied as the anti-aging and UV-B protective formulation [116].…”

Section: Advances In Skin Formulationsmentioning

confidence: 99%

Recent Advances in the Structural Design of Photosensitive Agent Formulations Using “Soft” Colloidal Nanocarriers

et al. 2020

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The growing demand for effective delivery of photosensitive active compounds has resulted in the development of colloid chemistry and nanotechnology. Recently, many kinds of novel formulations with outstanding pharmaceutical potential have been investigated with an expansion in the design of a wide variety of “soft” nanostructures such as simple or multiple (double) nanoemulsions and lipid formulations. The latter can then be distinguished into vesicular, including liposomes and “smart” vesicles such as transferosomes, niosomes and ethosomes, and non-vesicular nanosystems with solid lipid nanoparticles and nanostructured lipid carriers. Encapsulation of photosensitive agents such as drugs, dyes, photosensitizers or antioxidants can be specifically formulated by the self-assembly of phospholipids or other amphiphilic compounds. They are intended to match unique pharmaceutic and cosmetic requirements and to improve their delivery to the target site via the most common, i.e., transdermal, intravenous or oral administration routes. Numerous surface modifications and functionalization of the nanostructures allow increasing their effectiveness and, consequently, may contribute to the treatment of many diseases, primarily cancer. An increasing article number is evidencing significant advances in applications of the different classes of the photosensitive agents incorporated in the ”soft” colloidal nanocarriers that deserved to be highlighted in the present review.

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Niosomal Nanocarriers for Enhanced Skin Delivery of Quercetin with Functions of Anti-Tyrosinase and Antioxidant

Cited by 69 publications

References 59 publications

Antioxidant and Antitumor Activities of Novel Quercetin-Loaded Electrospun Cellulose Acetate/Polyethylene Glycol Fibrous Materials

Antioxidant and Antitumor Activities of Novel Quercetin-Loaded Electrospun Cellulose Acetate/Polyethylene Glycol Fibrous Materials

Nanoformulations to Enhance the Bioavailability and Physiological Functions of Polyphenols

Recent Advances in the Structural Design of Photosensitive Agent Formulations Using “Soft” Colloidal Nanocarriers

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