Niosomal methotrexate gel in the treatment of localized psoriasis: Phase I and phase II studies

Lakshmi, P. K.; Devi, Gayathri S; Bhaskaran, Shyamala; Sacchidanand, S

doi:10.4103/0378-6323.32709

Cited by 87 publications

(45 citation statements)

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“…The most frequent type is a mild psoriasis, which mainly requires topical treatment. In this context, methotrexate still has a golden role in psoriasis treatment [36][37][38][39][40].…”

Section: Introductionmentioning

confidence: 99%

Functionalized gold nanoparticles for topical delivery of methotrexate for the possible treatment of psoriasis

Bessar

Venditti

Benassi

et al. 2016

Colloids and Surfaces B: Biointerfaces

109

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a b s t r a c tGold nanoparticles (AuNPs) represent an effective choice for topical drug delivery systems thanks to their small size, general non-toxicity, ease of functionalization and high surface to volume ratio. Even if systemic, methotrexate still plays an important role in psoriasis treatment: its topical use shows insufficient percutaneus penetration owing to limited passive diffusion, high molecular weight and dissociation at physiological pH. The aim of our study was to design a new drug delivery nanocarrier for Methotrexate and to improve its solubility, stability and biodistribution. AuNPs were on purpose prepared with a hydrophilic stabilizing layer, in order to improve the colloidal stability in water. Watersoluble gold nanoparticles functionalized by sodium 3-mercapto-1-propansulfonate (Au-3MPS) were prepared and loaded with methotrexate (MTX). The loading efficiency of MTX on Au-3MPS was assessed in the range 70-80%, with a fast release (80% in one hour). The release was studied up to 24 h reaching the value of 95%. The Au-3MPS@MTX conjugate was fully characterized by spectroscopic techniques (UV-vis, FTIR) and DLS. Preliminary toxicity tests in the presence of keratinocytes monolayers allowed to assess that the used Au-3MPS are not toxic. The conjugate was then topically used on C57BL/6 mouse normal skin in order to trace the absorption behavior. STEM images clearly revealed the distribution of gold nanoparticles inside the cells. In vitro studies showed that Methotrexate conjugated with Au-3MPS is much more efficient than Methotrexate alone. Moreover, DL50, based on MTT analysis, is 20 folds reduced at 48 h, by the presence of nanoparticles conjugation. UV-vis spectra for in vivo tracing of the conjugate on bare mouse skin after 24 h of application, show increased delivery of Methotrexate in the epidermis and dermis using Au-3MPS@MTX conjugate, compared to MTX alone. Moreover we observed absence of the Au-3MPS in the dermis and in the epidermis, suggesting that these layers of the skin do not retain the nanoparticles. Based on our data, we found that the novel Au-3MPS@MTX conjugate is an effective non-toxic carrier for the satisfactory percutaneous absorption of Methotrexate and could help in possible topical treatment of psoriasis.

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“…The most frequent type is a mild psoriasis, which mainly requires topical treatment. In this context, methotrexate still has a golden role in psoriasis treatment [36][37][38][39][40].…”

Section: Introductionmentioning

confidence: 99%

Functionalized gold nanoparticles for topical delivery of methotrexate for the possible treatment of psoriasis

Bessar

Venditti

Benassi

et al. 2016

Colloids and Surfaces B: Biointerfaces

109

View full text Add to dashboard Cite

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“…There was a three times reduction in PASI scores after 12 weeks of niosomal methotrexate gel. The results of study offer niosomal formulation of methotrexate for dermal treatment of psoriasis due to its better clinical efficacy, tolerability and patient compliance (Lakshmi et al, 2007). Urea is an emollient topically used for the non-surgical removal of dystrophic nails in cases of fungal infections for decades and used as a penetration enhancer for the topical corticosteroid treatment of hyperkeratotic psoriatic plaques (Draelos, 2008).…”

Section: Psoriasismentioning

confidence: 99%

Niosomes as Carrier in Dermal Drug Delivery

Rahimpour¹,

Hamishehkar²

2012

Recent Advances in Novel Drug Carrier Systems

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“…Methotrexate-loaded niosomal vesicles in chitosan gel were used in the treatment of psoriasis by double blind, placebo controlled study on healthy human volunteers and psoriasis patients [101]. Kaur et al showed 6.5 times higher drug deposition in deep skin layers and muscles from celecoxib niosomal gels compared with carbopol gel indicating better drug localization with niosomal gel [102]. In the same study, a significant reduction of rat paw edema was resulted after administration of niosomal formulation compared to that of applying conventional gel.…”

Section: Niosomes For Transdermal Delivery Of Drugsmentioning

confidence: 99%

Hydrogels and Their Combination with Liposomes, Niosomes, or Transfersomes for Dermal and Transdermal Drug Delivery

Ibrahim¹,

Nair²,

Al‐Dhubiab³

et al. 2017

Liposomes

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Polymeric networks that retain and absorb substantial amount of water or biological fluids and resemble as a biological tissue are defined as hydrogels. On the other hand, liposomes, transfersomes and niosomes are lipid carriers, which represent one of the major research and development focus areas of the pharmaceutical industry. They have great potential as lipid vehicles that are able to enhance permeation of drugs across the intact skin and can act as local depot for the drug to sustain and control its delivery. Lipid carrier and hydrogel combinations offer transdermal drug delivery of great potential to enhance systemic effects of both hydrophilic and lipophilic drugs. Also, lipid carriers can target drugs to skin appendages and improve transdermal delivery. Lipid carrier proform systems in the form of gelly liquid crystals can also be used transdermally for better drug absorption enhancement. This review highlights the potential of hydrogels and emulgels with or without lipid nanocarriers for dermal and transdermal application.

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Niosomal methotrexate gel in the treatment of localized psoriasis: Phase I and phase II studies

Abstract: These results suggest that niosomal methotrexate gel is more efficacious than placebo and marketed methotrexate gel.

Cited by 87 publications

References 0 publications

Functionalized gold nanoparticles for topical delivery of methotrexate for the possible treatment of psoriasis

Functionalized gold nanoparticles for topical delivery of methotrexate for the possible treatment of psoriasis

Niosomes as Carrier in Dermal Drug Delivery

Hydrogels and Their Combination with Liposomes, Niosomes, or Transfersomes for Dermal and Transdermal Drug Delivery

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