Niobium Carbide Protects Myocardial Ischemia/Reperfusion Injury by Scavenging Reactive Oxygen Species and Improving Mitochondrial Function
Hong-Wei Wang,
Li-Na Cheng,
Liang Zang
et al.
Abstract:Myocardial ischemia/reperfusion (IR) injury is a significant annual clinical threat. Reperfusion injury exacerbates this issue by causing an excessive overload of reactive oxygen species (ROS) due to heme degradation and dysfunction in mitochondrial complexes. Subsequently, this surge in ROS leads to mitochondrial damage, further compromising cardiomyocyte mitochondrial function and eventually causing cell death. Given its pivotal role, targeting ROS has emerged as a viable strategy for treating myocardial isc… Show more
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