Nine-Year Incidence of Open-Angle Glaucoma in the Barbados Eye Studies

Leske, M. Cristina; Wu, Suh‐Yuh; Honkanen, Robert; Nemesure, Barbara; Schachat, Andrew P.; Hyman, Leslie; Hennis, Anselm

doi:10.1016/j.ophtha.2006.08.051

Cited by 202 publications

(215 citation statements)

References 22 publications

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“…21,22 Although travoprost monotherapy has shown a meaningful IOP efficacy in the short term, [11][12][13][14][15][16] there is limited information on the long-term efficacy (Z12 mo). 23 However, previous clinical trials with latanoprost monotherapy, another prostaglandin analogue, have established a long-lasting daytime hypotensive effect with little evidence of tachyphylaxis, for up to 4 years.…”

Section: Discussionmentioning

confidence: 99%

Long-term 24-hour Intraocular Pressure Control With Travoprost Monotherapy in Patients With Primary Open-angle Glaucoma

Riva

Katsanos

Floriani

et al. 2014

Journal of Glaucoma

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Purpose: The aim of the study was to evaluate the long-term 24-hour intraocular pressure (IOP) efficacy of travoprost monotherapy in primary open-angle glaucoma patients.Patients and Methods: A total of 36 previously untreated primary open-angle glaucoma patients were enrolled in this 5-year study.Patients underwent an untreated 24-hour IOP evaluation. Subsequently all patients were assigned to topical therapy with travoprost 0.004% eye-drops preserved with benzalkonium chloride (Travatan, Alcon Laboratories Inc., Fort Worth, TX) administered once in the evening (8:00 PM) in both eyes. All patients were then scheduled for a 24-hour IOP assessment approximately 12 months after the baseline visit. This schedule of follow-up was maintained for the whole duration of the trial. The predetermined range of target IOP reduction selected in this cohort of patients ranged between 20% and 30%.Results: A total of 34 patients completed all phases of the investigation. The mean survival time was 57.3 ± 2.0 months and the cumulative survival rate was 0.82 ± 0.6 at 60 months. Travoprost reduced the mean 24-hour IOP from 23.4 ± 1.7 mm Hg at baseline to 16.8 ± 2.4 mm Hg (28.4%), 16.8 ± 2.5 mm Hg (28.1%), 16.8 ± 2.4 mm Hg (28.5%), 16.7 ± 2.5 mm Hg (28.6%), and 16.9 ± 2.4 mm Hg (27.8%), respectively at the end of the first, second, third, fourth, and fifth year follow-up. No drug-related serious adverse events were registered during the study.Conclusions: The present study demonstrated the long-term 24-hour efficacy of travoprost for the treatment of primary open-angle glaucoma.Key Words: open-angle glaucoma, prostaglandin analogue, circadian intraocular pressure, travoprost (J Glaucoma 2014;23:535-540) R eduction of intraocular pressure (IOP) is the only currently available, evidence-based management strategy in patients affected with primary open-angle glaucoma (POAG). Most POAG patients will require lifelong medical therapy to avoid visual loss. The decision to select medical therapy options relies primarily on the efficacy of the available medications in various therapeutic trials. Sadly, most published studies only evaluate the short-term, daytime efficacy of medical therapy.Prostaglandin analogues have become a popular firstline therapy option for lowering IOP in POAG owing to their superior 24-hour efficacy, 1-6 convenient once-a-day administration, 5 and favorable systemic safety profile. 7 Travoprost is a synthetic prostaglandin F2a analogue that exerts its IOP-lowering effect through the prostaglandin FP receptors situated at the ciliary muscle 8 and the trabecular meshwork. 9 Travoprost is increasingly becoming a popular first-line monotherapy option for POAG patients 10 as there is cumulative evidence suggesting good quality of shortterm 24-hour IOP control with low fluctuation, especially with evening administration. 11-13 However, although several controlled studies have demonstrated the daytime short-term efficacy of travoprost monotherapy, [14][15][16] little is currently known about its long-term efficacy.As POA...

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Section: Discussionmentioning

confidence: 99%

Long-term 24-hour Intraocular Pressure Control With Travoprost Monotherapy in Patients With Primary Open-angle Glaucoma

Riva

Katsanos

Floriani

et al. 2014

Journal of Glaucoma

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“…Increased intraocular pressure (IOP) poses the most important known risk factor with a positive correlation between both prevalence and incidence in glaucoma. [2][3][4] However, some patients deteriorate despite normal IOP indicating that other factors are also at play. As such, vascular factors including altered blood flow have been proposed to contribute to the pathogenesis of glaucoma.…”

Section: Introductionmentioning

confidence: 99%

Regulation of Optic Nerve Head Blood Flow during Combined Changes in Intraocular Pressure and Arterial Blood Pressure

Boltz

Schmidl

Werkmeister

et al. 2013

J Cereb Blood Flow Metab

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In the choroid, there is evidence that blood flow does not only depend on ocular perfusion pressure (OPP), but also on absolute mean arterial pressure (MAP) and intraocular pressure (IOP). The present study included 40 healthy subjects to investigate whether such behavior is also found in the optic nerve head (ONH). The ONH blood flow (ONHBF) was studied using laser Doppler flowmetry during a separate increase in IOP and MAP as well as during a combined elevation. Mean arterial pressure was increased by isometric exercise and IOP by the suction method. During both, the change in ONHBF was less pronounced than the change in OPP indicating autoregulation. Correlation analysis was performed for the combined experiments after pooling all data according to IOP and MAP values. A correlation between ONHBF and MAP was found at IOPs p25 mm Hg (Po0.001), but not at IOPs425 mm Hg (P ¼ 0.79). Optic nerve head blood flow and IOP were significantly correlated (Po0.001), and ONHBF was only slightly dependent on MAP. The data of the present study indicate a complex regulation of ONHBF during combined changes in MAP and IOP. Our results may be compatible with myogenic mechanisms underlying autoregulation, and indicate better ONHBF regulation during an increase in MAP than during an increase in IOP.

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“…Blacks are more likely to have glaucoma than Whites; the disease is one of the leading causes of blindness in this group. 4,5 Given the significant individual and economic consequences of glaucoma, prevention strategies are essential if we hope to decrease the burden of this eye condition.…”

mentioning

confidence: 99%

Glaucoma Risk and the Consumption of Fruits and Vegetables Among Older Women in the Study of Osteoporotic Fractures

Coleman

Stone

Kodjebacheva

et al. 2008

American Journal of Ophthalmology

102

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Nine-Year Incidence of Open-Angle Glaucoma in the Barbados Eye Studies

Cited by 202 publications

References 22 publications

Long-term 24-hour Intraocular Pressure Control With Travoprost Monotherapy in Patients With Primary Open-angle Glaucoma

Long-term 24-hour Intraocular Pressure Control With Travoprost Monotherapy in Patients With Primary Open-angle Glaucoma

Regulation of Optic Nerve Head Blood Flow during Combined Changes in Intraocular Pressure and Arterial Blood Pressure

Glaucoma Risk and the Consumption of Fruits and Vegetables Among Older Women in the Study of Osteoporotic Fractures

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