Nine polymorphic STR loci in the HLA region in the Shaanxi Han population of China

Zhang, H.B.; Wei, Shaoceng; Yu, Bing; Li, L.; Lai, Jianghua

doi:10.4238/2012.july.10.8

Cited by 3 publications

(1 citation statement)

References 17 publications

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“…So far NGS/MPS is limited to highly specialized and adequately equipped laboratories . STR loci in the HLA region (HLA STR) can be investigated for population genetics, disease association and recombination studies, major histocompatibility complex region mapping, and selection of donors for transplantation . Linkage disequilibria (LD) of STRs have already been suggested and observed with HLA alleles and haplotypes .…”

Section: Introductionmentioning

confidence: 99%

Standardized genotyping of HLA STR by CE as surrogate for HLA class I and II markers and for identification of HLA identical siblings

et al. 2016

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Linkage disequilibria (LD) between alleles and haplotypes of human leucocyte antigen, locus A (HLA) and STR loci located in the human major histocompatibility complex were analyzed in order to investigate whether or not HLA alleles and haplotypes are predictable by alleles or haplotypes of HLA STRs. Standardized genotyping of eight STR loci (D6S2972, D6S2906, D6S2691, D6S2678, D6S2792, D6S2789, D6S273, and DQIV) was performed by CE on 600 individuals from 150 Austrian Caucasoid families with known HLA-A,-B,-C and -DRB1 typing. From those, 576 full haplotypes of four HLA and eight STR loci were obtained. Haplotypes of two flanking STRs predicted HLA alleles and two-locus HLA haplotypes better than single STR alleles, except HLA-DRB1 alleles (92% were in LD with DQIV alleles only). A percentage of 65-86% of three and four-locus HLA haplotypes were in LD with haplotypes of three, four, and eight of their flanking STR loci including numerous clear-cut predictions (20-61%). All eight and a set of the four most informative STR loci D6S2972, D6S2678, D6S2792, and DQIV could identify all HLA identical and nonidentical siblings in 138 pairs of siblings. The results of this proof of concept study in Austrian Caucasoids show, that HLA STRs can aid the definition of HLA-A,-B,-C,-DRB1 haplotypes and the selection of sibling donors for stem cell transplantation.

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Section: Introductionmentioning

confidence: 99%

Standardized genotyping of HLA STR by CE as surrogate for HLA class I and II markers and for identification of HLA identical siblings

et al. 2016

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Population genetic data of 15 STR loci in Gansu Han population from China

Sun

Zhang

et al. 2014

Int J Legal Med

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The genetic polymorphisms of 15 autosomal short tandem repeat (STR) loci included in the AmpFISTR Sinofiler™ kit were evaluated in 547 healthy unrelated Han individuals from Gansu, China. All of the loci reached the Hardy-Weinberg equilibrium after the Bonferroni correction (p > 0.0033). These loci were examined to determine allele frequencies and forensic statistical parameters. The combined discrimination power and probability of excluding paternity of the 15 STR loci were 0.999999 and 0.995097, respectively. Results suggested that the 15 STR loci are highly polymorphic, which is suitable for forensic personal identification and paternity testing.

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