Nine differentially expressed genes from a post mortem study and their association with suicidal status in a sample of suicide completers, attempters and controls

Balestri, Martina; Crisafulli, C.; Donato, Luigi; Giegling, Ina; Calati, Raffaella; Antypa, Niki; Tarozzi, Maria Eugenia; Marušič, Dragan; Paragi, Metka; Hartmann, Annette M.; Konte, Bettina; Marsano, Agnese; Serretti, Alessandro; Rujescu, Dan

doi:10.1016/j.jpsychires.2017.03.009

Cited by 7 publications

(1 citation statement)

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“…A study performed using the orbitofrontal cortex brain tissues of suicide victims showed the overexpression of ZFP36 73 . However, further studies were unable to confirm that there is a connection between a single-nucleotide polymorphism (SNP) of this gene and suicidal behavior 74 . We have detected an overexpression of this gene in the brains of rats subjected to the FST, which implies a connection between changes in the expression of this gene and stress.…”

Section: Discussionmentioning

confidence: 99%

Differential expression of Dusp1 and immediate early response genes in the hippocampus of rats, subjected to forced swim test

Vlasov

Filatova

Slominsky

et al. 2023

Sci Rep

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The forced swim test (FST) is widely used to screen for potential antidepressant drugs and treatments. Despite this, the nature of stillness during FST and whether it resembles “depressive-like behavior” are widely debated issues. Furthermore, despite being widely used as a behavioral assay, the effects of the FST on the brain transcriptome are rarely investigated. Therefore, in this study we have investigated changes in the transcriptome of the rat hippocampus 20 min and 24 h after FST exposure. RNA-Seq is performed on the hippocampus tissues of rats 20 min and 24 h after an FST. Differentially expressed genes (DEGs) were identified using limma and used to construct gene interaction networks. Fourteen differentially expressed genes (DEGs) were identified only in the 20-m group. No DEGs were identified 24 h after the FST. These genes were used for Gene Ontology term enrichment and gene-network construction. Based on the constructed gene-interaction networks, we identified a group of DEGs (Dusp1, Fos, Klf2, Ccn1, and Zfp36) that appeared significant based on multiple methods of downstream analysis. Dusp1 appears especially important, as its role in the pathogenesis of depression has been demonstrated both in various animal models of depression and in patients with depressive disorders.

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Section: Discussionmentioning

confidence: 99%