Nine cases of acute gastric anisakiasis

Ikeda, Koh; Kumashiro, Ryunosuke; Kifune, Teiji

doi:10.1016/s0016-5107(89)72797-8

Cited by 45 publications

(16 citation statements)

References 6 publications

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“…25,37 Symptoms are probably due to liberation of proteolytic enzymes by the nematode. 4,6,38 Positive skin prick tests and specific IgE have been detected in these patients. 4,6,38 Positive skin prick tests and specific IgE have been detected in these patients.…”

Section: Discussionmentioning

confidence: 85%

Gastric anisakiasis: an underestimated cause of acute urticaria and angio‐oedema?

Daschner

Alonso-Gómez²,

Caballero³

et al. 1998

British Journal of Dermatology

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Acute urticaria and angio-oedema are common in primary care and in the emergency unit. Food allergy is one possible cause. We describe gastric anisakiasis, in which symptoms are often not obviously related to eating raw fish. A study was made of patients presenting at the emergency department who had allergic symptoms such as urticaria or angio-oedema and had recently eaten raw or undercooked fish. They were divided into two groups. Patients in group A (n = 13) also had abdominal symptoms and were diagnosed as having gastric anisakiasis by fibre-optic gastroscopy where third-stage larvae of Anisakis simplex were visualized and extracted. Skin prick tests and specific IgE to A. simplex were positive. Patients in group B (n = 13) had only allergic symptoms after eating raw fish. Eleven of 13 patients had positive skin prick tests and specific IgE to A. simplex. Three of 15 control subjects had positive skin prick tests and specific IgE to A. simplex. Allergic symptoms appeared from 2 to 20 h (mean 5.0) after ingestion in group A and from 20 min to 23 h (mean 4.3 h) in group B. Gastric symptoms in group A disappeared rapidly after extraction of the larvae. Allergic symptoms disappeared in most cases within the first 24 h. We suggest that the allergic symptoms in group A as well as in group B were mainly due to parasitization by A. simplex in sensitized patients. Gastric anisakiasis may be a widely underdiagnosed clinical entity.

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Section: Discussionmentioning

confidence: 85%

Gastric anisakiasis: an underestimated cause of acute urticaria and angio‐oedema?

Daschner

Alonso-Gómez²,

Caballero³

et al. 1998

British Journal of Dermatology

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“…Furthermore, more than 90% of the cases described are caused by a single larva (71,120,134). Differences may therefore be expected between A. simplex pathogenesis and that caused by other helminths in humans.…”

Section: Pathogenicitymentioning

confidence: 99%

Anisakis simplex: from Obscure Infectious Worm to Inducer of Immune Hypersensitivity

2008

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SUMMARY Infection of humans with the nematode worm parasite Anisakis simplex was first described in the 1960s in association with the consumption of raw or undercooked fish. During the 1990s it was realized that even the ingestion of dead worms in food fish can cause severe hypersensitivity reactions, that these may be more prevalent than infection itself, and that this outcome could be associated with food preparations previously considered safe. Not only may allergic symptoms arise from infection by the parasites (“gastroallergic anisakiasis”), but true anaphylactic reactions can also occur following exposure to allergens from dead worms by food-borne, airborne, or skin contact routes. This review discusses A. simplex pathogenesis in humans, covering immune hypersensitivity reactions both in the context of a living infection and in terms of exposure to its allergens by other routes. Over the last 20 years, several studies have concentrated on A. simplex antigen characterization and innate as well as adaptive immune response to this parasite. Molecular characterization of Anisakis allergens and isolation of their encoding cDNAs is now an active field of research that should provide improved diagnostic tools in addition to tools with which to enhance our understanding of pathogenesis and controversial aspects of A. simplex allergy. We also discuss the potential relevance of parasite products such as allergens, proteinases, and proteinase inhibitors and the activation of basophils, eosinophils, and mast cells in the induction of A. simplex-related immune hypersensitivity states induced by exposure to the parasite, dead or alive.

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“…In such cases the larvae may penetrate into the gastrointestinal mucosa, causing gastric or intestinal anisakiasis (Sakanari and McKerow 1989;Kikuchi et al 1990). Although most cases have been described in Japan (Ikeda et al 1989;Kagei and Isogaki 1992;Matsumoto et al 1992) in the last few years they have increased world-wide even in many countries where less ®sh is consumed (Petithory and Marty 1988). Moreover, allergic and anaphylactoid reactions caused by A. simplex s.l.…”

Section: Introductionmentioning

confidence: 99%

Anisakis infestation in marine fish and cephalopods from Galician waters: an updated perspective

Abollo

Gestal

Pascual

2001

Parasitology Research

177

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A total of 2,673 fresh specimens of cephalopod and fish representing 35 species were obtained from commercial local fisheries in Galician waters (NW Spain). They were examined for anisakid nematodes by digestion of the muscle and elution of the viscera and whole body cavity. All larval nematodes recovered were identified by light microscopy and multilocus electrophoresis as belonging to the species Anisakis simplex sensu stricto and A. pegreffii. Encysted larvae mostly occurred in the viscera but were also found in the flesh of squid and fish. Demographic values for larval nematodes are discussed in relation to host preferences and the ecological niche of both anisakid species at the sampling area. Primary recommendations are also expressed concerning the effects of current fishing and aquaculture practices on the Anisakis problem.

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Nine cases of acute gastric anisakiasis

Cited by 45 publications

References 6 publications

Gastric anisakiasis: an underestimated cause of acute urticaria and angio‐oedema?

Gastric anisakiasis: an underestimated cause of acute urticaria and angio‐oedema?

Anisakis simplex: from Obscure Infectious Worm to Inducer of Immune Hypersensitivity

Anisakis infestation in marine fish and cephalopods from Galician waters: an updated perspective

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