Nimesulide and indomethacin induce apoptosis in head and neck cancer cells

Abstract

The results of our study on HNSCC cells together with data from different studies showing anti-cancer activity of NSAIDs suggest that COX inhibitors could play a role in HNSCC treatment and prevention.

The Cyclooxygenase-2 Inhibitor Nimesulide, a Nonsteroidal Analgesic, Decreases the Effect of Radiation Therapy in Head-and-Neck Cancer Cells

“…Liu et al found a radiosensitizing effect of the selective COX-2 inhibitor celecoxib in breast tumor cell line MCa-35 but not in lung carcinoma cell line A549, although both cell lines express COX-2 [25]. Both cell lines used for our study, SCC25 and SCC9, express COX-2 as has recently been demonstrated by our group [33], but neither of them is radiosensitized by the COX-2 inhibitor nimesulide. Taken together, these observations may indicate that some effects of selective COX-2 inhibitors are cell-type-or tissue-type-specific.…”

“…Our group has recently reported high-level expression of COX-2 enzyme in these cells [33]. At first, we determined the effect of irradiation on cell survival in both cell lines.…”

The effect of nimesulide, a selective cyclooxygenase‐2 inhibitor, on Ets‐1 and Ets‐2 expression in head and neck cancer cell lines

“…30 As we demonstrated recently in our laboratory, nimesulide induced apoptosis in head and neck cancer cell lines. 17 In this study, we demonstrated that the selective COX-2 inhibitor nimesulide is also antiproliferative against HNSCC cell lines, possibly because of the reduction of the protooncogenes Ets-1 and Ets-2.…”

“…7 Recently, we showed in our laboratory that nimesulide was able to induce apoptosis in head and neck cancer cell lines SCC-9 and SCC-25. 17 In this study, we investigated the effect of nimesulide on the expression of two transcription factors, protooncogenes Ets-1 and Ets-2, in HNSCC cell lines.…”

Anti-Proliferative Effects of Piroxicam and Nimesulide on A431 Human Squamous Carcinoma Cell Line

“…On the other hand, nimesulide is a highly selective COX-2 inhibitor and its cytotoxic effects have been evaluated in some cancer cell lines such as head and neck squamous cell carcinoma, colon carcinoma and pancreatic cancer (21)(22)(23).…”