Nilotes from Karamoja, Uganda: Haplotype data defined by 17 Y-chromosome STRs

Gomes, Verónica; Alves, Cı́ntia; Amorim, António; Carracedo, Ángel; Sánchez-Diz, Paula; Gusmão, Leonor

doi:10.1016/j.fsigen.2009.07.001

Cited by 11 publications

(6 citation statements)

References 14 publications

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“…A sample of 118 unrelated individuals from Uganda, previously studied for 17 Y-STRs (Gomes et al 2009), was genotyped for a large set of Y-SNPs belonging to the main haplogroups represented in sub-Saharan Africa populations. Both SNP and STR data are available in supplemental Table 3.…”

Section: Resultsmentioning

confidence: 99%

Digging deeper into East African human Y chromosome lineages

et al. 2010

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The most significant and widely studied remodeling of the African genetic landscape is the Bantu expansion, which led to an almost total replacement of the previous populations from the sub-Saharan region. However, a poor knowledge exists about other population movements, namely, the Nilotic migration, which is a pastoralist dispersal that, contrary to the Bantu expansion, impacted only East African populations. Here, samples from a Ugandan Nilotic-speaking population were studied for 37 Y chromosome-specific SNPs, and the obtained data were compared with those already available for other sub-Saharan population groups. Although Uganda lies on the fringe of both Bantu and Nilotic expansions, a low admixture with Bantu populations was detected, with haplogroups carrying M13, M182 and M75 mutations prevailing in Nilotes together with a low frequency of the main Bantu haplogroups from clade E1b1a-M2. The results of a comparative analysis with data from other population groups allowed a deeper characterization of some lineages in our sample, clarifying some doubts about the origin of some particular Y-SNPs in different ethnic groups, such as M150, M112 and M75. Moreover, it was also possible to identify a new Y-SNP apparently specific to Nilotic groups, as well as the presence of particular haplogroups that characterize Nilotic populations. The detection of a new haplogroup B2a1b defined by G1, could be, therefore, important to differentiate Nilotes from other groups, helping to trace migration and admixture events that occurred in eastern Africa.

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Section: Resultsmentioning

confidence: 99%

Digging deeper into East African human Y chromosome lineages

et al. 2010

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“…The results obtained from Equatorial Guinea were compared with available data for other African populations 5,[33][34][35] (see Supplementary Figure S2 and Table 1). However, Africa is still a poorly studied continent, and data for comparative analysis were not always accessible.…”

Section: Characterisation Of the Male Lineages Of Equatorial Guineamentioning

confidence: 99%

The genetic landscape of Equatorial Guinea and the origin and migration routes of the Y chromosome haplogroup R-V88

et al. 2012

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Human Y chromosomes belonging to the haplogroup R1b1-P25, although very common in Europe, are usually rare in Africa. However, recently published studies have reported high frequencies of this haplogroup in the central-western region of the African continent and proposed that this represents a 'back-to-Africa' migration during prehistoric times. To obtain a deeper insight into the history of these lineages, we characterised the paternal genetic background of a population in Equatorial Guinea, a Central-West African country located near the region in which the highest frequencies of the R1b1 haplogroup in Africa have been found to date. In our sample, the large majority (78.6%) of the sequences belong to subclades in haplogroup E, which are the most frequent in Bantu groups. However, the frequency of the R1b1 haplogroup in our sample (17.0%) was higher than that previously observed for the majority of the African continent. Of these R1b1 samples, nine are defined by the V88 marker, which was recently discovered in Africa. As high microsatellite variance was found inside this haplogroup in Central-West Africa and a decrease in this variance was observed towards Northeast Africa, our findings do not support the previously hypothesised movement of Chadic-speaking people from the North across the Sahara as the explanation for these R1b1 lineages in Central-West Africa. The present findings are also compatible with an origin of the V88-derived allele in the Central-West Africa, and its presence in North Africa may be better explained as the result of a migration from the south during the mid-Holocene.

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“…Two of the noncore markers, DYS456 and DYS458, were included in the panel of this study as they were the most informative markers in the AmpF l STR®Y filer TM Kit. The remaining seven noncore Y‐STRs were included in this study as they were reported in various populations with high polymorphism and mutation rates compared to those of the commonly used loci .…”

Section: Discussionmentioning

confidence: 99%

Genetic diversity and haplotype structure of 21 Y‐STRs, including nine noncore loci, in South Tunisian Population: Forensic relevance

et al. 2015

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Y chromosome STRs (Y-STRs) are being used frequently in forensic laboratories. Previous studies of Y-STR polymorphisms in different groups of the Tunisian population identified low levels of diversity and discrimination capacity (DC) using various commercial marker sets. This definitely limits the use of such systems for Y-STRs genotyping in Tunisia. In our investigation on South Tunisia, 200 unrelated males were typed for the 12 conventional Y-STRs included in the PowerPlex® Y System. Additional set of nine noncore Y-STRs including DYS446, DYS456, DYS458, DYS388, DYS444, DYS445, DYS449, DYS710, and DYS464 markers were genotyped and evaluated for their potential in improving DC. Allele frequency, gene diversity, haplotype diversity (HD), and DC calculation revealed that DYS464 was the most diverse marker followed by DYS710 and DYS449 markers. The standard panel of 12 Y-STRs (DC = 80.5%) and the nine markers were combined to obtain DC of 99%. Among the 198 different haplotypes observed, 196 haplotypes were unique (HD = 99.999). Out of the nine noncore set, six Y-STRs (DYS458, DYS456, DYS449, DYS710, DYS444, and DYS464) had the greatest impact on enhancing DC. Our data provided putative Y-STRs combination to be used for genetic and forensic applications.

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Nilotes from Karamoja, Uganda: Haplotype data defined by 17 Y-chromosome STRs

Cited by 11 publications

References 14 publications

Digging deeper into East African human Y chromosome lineages

Digging deeper into East African human Y chromosome lineages

The genetic landscape of Equatorial Guinea and the origin and migration routes of the Y chromosome haplogroup R-V88

Genetic diversity and haplotype structure of 21 Y‐STRs, including nine noncore loci, in South Tunisian Population: Forensic relevance

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