NIH research opportunities for the prevention and treatment for chronic conditions

Elwood, William N.; Huss, Karen; Morales, Dawn A.; Norton, Jenna M.; Riddle, Melissa; Roof, Rebecca A.; Suls, Jerry; Stoney, Catherine M.; Bavendam, Tamara; Kirkali, Ziya

doi:10.1093/tbm/ibx085

Cited by 3 publications

(4 citation statements)

References 18 publications

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“…Diabetes mellitus (DM) has reached the epidemic dimension around the world. The rising incidence of DM brings a heavy burden to the society and individual family 1 . A great number of oral hypoglycemic agents, such as biguanides and sulfonylureas, are available for DM treatment, but these synthetic hypoglycemic agents are connected to certain shortfalls 2 , including hypoglycemia, gastrointestinal discomfort, liver impairment, and pancreatic degeneration.…”

Section: Introductionmentioning

confidence: 99%

Selenium-layered nanoparticles serving for oral delivery of phytomedicines with hypoglycemic activity to synergistically potentiate the antidiabetic effect

Deng

Wang

et al. 2019

Acta Pharmaceutica Sinica B

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Diabetes mellitus (DM) remains a great challenge in treatment due to pathological complexity. It has been proven that phytomedicines and natural medicines have prominent antidiabetic effects. This work aimed to develop selenium-layered nanoparticles (SeNPs) for oral delivery of mulberry leaf and Pueraria Lobata extracts (MPE), a group of phytomedicines with significant hypoglycemic activities, to achieve a synergic antidiabetic effect. MPE-loaded SeNPs (MPE-SeNPs) were prepared through a solvent diffusion/in situ reduction technique and characterized by particle size, ζ potential, morphology, entrapment efficiency (EE) and drug loading (DL). The resulting MPE-SeNPs were 120 nm around in particle size with EE of 89.38% for rutin and 90.59% for puerarin, two marker components in MPE. MPE-SeNPs exhibited a slow drug release and good physiological stability in the simulated digestive fluid. After oral administration, MPE-SeNPs produced significant hypoglycemic effects both in the normal and diabetic rats. Ex vivo intestinal imaging and cellular examinations demonstrated that MPE-SeNPs were provided with outstanding intestinal permeability and transepithelial transport aptness. It was also revealed that MPE-SeNPs could alleviate the oxidative stress, improve the pancreatic function, and promote the glucose utilization by adipocytes. Our study provides new insight into the use of integrative nanomedicine containing phytomedicines and selenium for DM treatment.

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Section: Introductionmentioning

confidence: 99%

Selenium-layered nanoparticles serving for oral delivery of phytomedicines with hypoglycemic activity to synergistically potentiate the antidiabetic effect

Deng

Wang

et al. 2019

Acta Pharmaceutica Sinica B

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“…These gaps were also identified, with a research agenda proposed for the VA, in several papers from a recent Special Issue on the Coordination of Chronic Care. 6,[59][60][61]…”

Section: Discussionmentioning

confidence: 99%

Health Care Coordination Theoretical Frameworks: a Systematic Scoping Review to Increase Their Understanding and Use in Practice

et al. 2019

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“…The conceptualisation of the results as interrelated factors answers the call for a socioecological approach to Open access supporting people with diabetes and obesity. 43 Interventions could then address the social, emotional, physical and psychological needs of the individual integratively. 43 For example, enhancing work-life balance and stress management by the government and employers could ameliorate the impact of overworking on the individual's mental well-being and health management, while promoting stronger support from family and peers could further enable them.…”

Section: Open Accessmentioning

confidence: 99%

“…43 Interventions could then address the social, emotional, physical and psychological needs of the individual integratively. 43 For example, enhancing work-life balance and stress management by the government and employers could ameliorate the impact of overworking on the individual's mental well-being and health management, while promoting stronger support from family and peers could further enable them. Online food delivery is a known risk factor for sedentary lifestyle and chronic diseases.…”

Section: Open Accessmentioning

confidence: 99%

Experiences of living with overweight/obesity and early type 2 diabetes in Singapore—a qualitative interview study

Lee,

Khoo,

Krishnasamy

et al. 2024

BMJ Open

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ObjectivesTo understand the lived experience of adults with overweight/obesity and early type 2 diabetes in a modern urban environment, and the interrelations among the various aspects of these experiences and participants’ attitudes to weight management.DesignQualitative inductive approach to analysing data thematically from semistructured interviews and interpreted from a socioecological perspective.SettingPrimary care clinics located in northern and central Singapore.Participants21 patients between 29 and 59 years old who are living with overweight/obese (Body Mass Index of 25.3–44.0kg/m2) and type 2 diabetes for 6 years or less.ResultsThe main themes–everyday life, people around me and within me–pointed to a combination of barriers to weight and health management for participants. These included environmental factors such as easy physical and digital access to unhealthy food, and high-stress work environments; social factors such as ambiguous family support and dietary practices of peers; and individual factors such as challenges with self-regulation, prioritising work, dealing with co-existing medical conditions and the emotional significance of food. While lack of motivation and cultural dietary practices are hard to change, a problem-solving attitude, and presence of role models, may enable behaviour change.ConclusionAn exploration of the lifeworld of patients with overweight/obese and early type 2 diabetes revealed that work demands, dietary practices in the workplace and at home, and the easy availability of calorie-dense foods afforded by a technology-infused environment hindered the individual’s efforts at maintaining a healthy weight and lifestyle. Policy and initiatives promoting work-life balance as well as individualised interventions can support participants’ stress management, and problem-solving capability for behaviour change. These barriers stemmed from the various domains of the environmental, interpersonal and intrapersonal but were interrelated. They underscored the need for an integrated approach to weight and diabetes management.

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NIH research opportunities for the prevention and treatment for chronic conditions

Cited by 3 publications

References 18 publications

Selenium-layered nanoparticles serving for oral delivery of phytomedicines with hypoglycemic activity to synergistically potentiate the antidiabetic effect

Selenium-layered nanoparticles serving for oral delivery of phytomedicines with hypoglycemic activity to synergistically potentiate the antidiabetic effect

Health Care Coordination Theoretical Frameworks: a Systematic Scoping Review to Increase Their Understanding and Use in Practice

Experiences of living with overweight/obesity and early type 2 diabetes in Singapore—a qualitative interview study

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