Nigrostriatal and mesolimbic control of sleep–wake behavior in rat

Qiu, Mei‐Hong; Zhong, Zhigang; Chen, Michael C.; Lü, Jun

doi:10.1007/s00429-019-01921-w

Cited by 16 publications

(16 citation statements)

References 39 publications

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“…[29,80] By using recently developed cell-typespecific optogenetic and chemogenetic approaches, recent work however has revealed a causal role of mDA neurons in inducing and maintaining electrocortical and behavioral arousal. [27][28][29][30][31][32][33] The necessity of VTA DA neurons for behavioral arousal was also shown by chemogenetic [27,30] and optogenetic [31] inhibitions that promoted sleep. Our study corroborates these findings by showing that chronic chemogenetic inhibition of mDA neurons induced a slight but sustained increase in NREM sleep over several days.…”

Section: Mda Mediates Motivational Context-related Modulation Of Slee...mentioning

confidence: 99%

“…However, the mechanisms by which this is achieved are still unknown. Basically, all previous studies have either examined the impact of DA manipulation on sleep/wake states [27][28][29][30][31][32][33] or unraveled the downstream neuronal circuitry mediating these effects. [34,35] Whether DA modulates sleep/wake states by its interaction with the homeostatic and/or the circadian processes of sleep regulation is not fully understood.…”

Section: Introductionmentioning

confidence: 99%

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Motivational and Valence‐Related Modulation of Sleep/Wake Behavior are Mediated by Midbrain Dopamine and Uncoupled from the Homeostatic and Circadian Processes

et al. 2022

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Motivation and its hedonic valence are powerful modulators of sleep/wake behavior, yet its underlying mechanism is still poorly understood. Given the well-established role of midbrain dopamine (mDA) neurons in encoding motivation and emotional valence, here, neuronal mechanisms mediating sleep/wake regulation are systematically investigated by DA neurotransmission. It is discovered that mDA mediates the strong modulation of sleep/wake states by motivational valence. Surprisingly, this modulation can be uncoupled from the classically employed measures of circadian and homeostatic processes of sleep regulation. These results establish the experimental foundation for an additional new factor of sleep regulation. Furthermore, an electroencephalographic marker during wakefulness at the theta range is identified that can be used to reliably track valence-related modulation of sleep. Taken together, this study identifies mDA signaling as an important neural substrate mediating sleep modulation by motivational valence.

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Section: Mda Mediates Motivational Context-related Modulation Of Slee...mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Motivational and Valence‐Related Modulation of Sleep/Wake Behavior are Mediated by Midbrain Dopamine and Uncoupled from the Homeostatic and Circadian Processes

et al. 2022

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“…These are inhibited both by noradrenaline through activation of postsynaptic α2-adrenoceptors [ 63 ] and also by acetylcholine [ 64 ]. The second important NREM controlling system is the parafacial zone (PZ) consisting of GABAergic neurons, which are necessary for the induction of deep NREM, expressed as slow-wave sleep [ 65 ]. The ventrolateral tegmental nucleus (VTA), which was first discovered to be a part of the arousal system because of its dopaminergic neurons, has been proven to play a role in promotion of NREM sleep because its GABAergic neurons inhibit both dopaminergic neurons and also the lateral hypothalamus region [ 66 , 67 ] Other GABAergic neurons located in the ventrolateral periaqueductal grey region (vlPAG) stabilize NREM sleep, reducing REM sleep episodes at the same time [ 68 ].…”

Section: Pathogenesis Of Migraine and Sleep Disordersmentioning

confidence: 99%

Migraine and Sleep—An Unexplained Association?

Waliszewska‐Prosół

Nowakowska-Kotas

Chojdak-Łukasiewicz

et al. 2021

IJMS

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Migraine and sleep disorders are common chronic diseases in the general population, with significant negative social and economic impacts. The association between both of these phenomena has been observed by clinicians for years and is confirmed by many epidemiological studies. Despite this, the nature of this relationship is still not fully understood. In recent years, there has been rapid progress in understanding the common anatomical structures of and pathogenetic mechanism between sleep and migraine. Based on a literature review, the authors present the current view on this topic as well as ongoing research in this field, with reference to the key points of the biochemical and neurophysiological processes responsible for both these disorders. In the future, a better understanding of these mechanisms will significantly expand the range of treatment options.

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“…Growing evidence has demonstrated that general anesthesia and sleep-wakefulness share homologous neural substrates (Nelson et al, 2002;Franks, 2008;Franks and Zecharia, 2011). Dopaminergic nuclei have been confirmed to be involved in the processes of both sleep-wake (Oishi and Lazarus, 2017;Qiu et al, 2019) and general anesthesia (Harrington, 2014;Li et al, 2019), in which the ventral tegmental area (VTA) dopaminergic (DA) neurons are specifically crucial. It has been suggested that the VTA promotes rapid eye movement (REM) sleep and waking from natural sleep (Leung et al, 2014;Taylor et al, 2016;van der Meij et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

Dopaminergic Projections From the Ventral Tegmental Area to the Nucleus Accumbens Modulate Sevoflurane Anesthesia in Mice

Gui

Liu

et al. 2021

Front. Cell. Neurosci.

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The role of the dopaminergic pathway in general anesthesia and its potential mechanisms are still unknown. In this study, we usedc-Fos staining combined with calcium fiber photometry recording to explore the activity of ventral tegmental area (VTA) dopaminergic neurons(VTA-DA) and nucleus accumbens (NAc) neurons during sevoflurane anesthesia. A genetically encoded dopamine (DA) sensor was used to investigate thefunction of the NAc in sevoflurane anesthesia. Chemogenetics and optogenetics were used to explore the role of the VTA-DA in sevofluraneanesthesia. Electroencephalogram (EEG) spectra, time of loss of righting reflex (LORR) and recovery of righting reflex (RORR) were recorded asassessment indicators. We found that VTA-DA and NAc neurons were inhibited during the induction period and were activated during the recoveryperiod of sevoflurane anesthesia. The fluorescence signals of dopamine decreased in the induction of and increased in the emergence from sevoflurane anesthesia.Activation of VTA-DA and the VTADA-NAc pathway delayed the induction and facilitated the emergence accompanying with thereduction of delta band and the augmentation of the gamma band. These data demonstrate that VTA-DA neurons play a critical role in modulating sevofluraneanesthesia via the VTADA-NAc pathway.

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Nigrostriatal and mesolimbic control of sleep–wake behavior in rat

Cited by 16 publications

References 39 publications

Motivational and Valence‐Related Modulation of Sleep/Wake Behavior are Mediated by Midbrain Dopamine and Uncoupled from the Homeostatic and Circadian Processes

Motivational and Valence‐Related Modulation of Sleep/Wake Behavior are Mediated by Midbrain Dopamine and Uncoupled from the Homeostatic and Circadian Processes

Migraine and Sleep—An Unexplained Association?

Dopaminergic Projections From the Ventral Tegmental Area to the Nucleus Accumbens Modulate Sevoflurane Anesthesia in Mice

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