Night Vision and Carotenoids (NVC): A Randomized Placebo Controlled Clinical Trial on Effects of Carotenoid Supplementation on Night Vision in Older Adults
Abstract:Twilight and low luminance levels are visually challenging environments for the elderly, especially when driving at night. Carotenoid rich diets are known to increase macular pigment optical density (MPOD), which in turn leads to an improvement in visual function. It is not known whether augmenting MPOD can lead to a decrease in vision related night driving difficulties. Additionally, it is unknown if carotenoid supplementation provides additional measurable benefits to one’s useful field of view (UFOV) along … Show more
“…These studies only observed primarily naive individuals that were not trained in this technology. In the present study [2], we find that the standard error is the same for both the baseline and final visits for macular pigment (MP) measurements, and it is therefore unlikely that this sample is different or special. We hope this is now clear.…”
Section: Repeatability Of Mpod Measurementsmentioning
confidence: 51%
“…Thank you for pointing out an error in a single data point in Figure 1B [2]. However, the text is correct.…”
Section: Repeatability Of Mpod Measurementsmentioning
confidence: 97%
“…As explained in Section 2.2 of our publication [2] (Instrumentation,)-The Vimetrics Central Vison Analyzer, a device developed by an ophthalmologist, measures the resolution threshold of each eye at fixation within six presentation modules representing varying degrees of contrast reduction under photopic and mesopic luminance conditions that represent real-world vision tasks at presentation times that simulate real-world fixations [9], and, as such, have demonstrated improved correlations with task performance under those conditions compared with chart measurements. Those with visual acuities below 20/100 were not tested or included.…”
“…Preferred Luminance-One can determine from a visual inspection of Figure 3 [2] that there is an appreciable difference between placebo and intervention groups in terms of change from baseline to 6 months, right and left eyes compared to the baseline data (t-test p = 0.02 and 0.03, respectively) using the simple clinical device and the statistical constraints imposed by post-randomization heterogeneity of variance.…”
“…These studies only observed primarily naive individuals that were not trained in this technology. In the present study [2], we find that the standard error is the same for both the baseline and final visits for macular pigment (MP) measurements, and it is therefore unlikely that this sample is different or special. We hope this is now clear.…”
Section: Repeatability Of Mpod Measurementsmentioning
confidence: 51%
“…Thank you for pointing out an error in a single data point in Figure 1B [2]. However, the text is correct.…”
Section: Repeatability Of Mpod Measurementsmentioning
confidence: 97%
“…As explained in Section 2.2 of our publication [2] (Instrumentation,)-The Vimetrics Central Vison Analyzer, a device developed by an ophthalmologist, measures the resolution threshold of each eye at fixation within six presentation modules representing varying degrees of contrast reduction under photopic and mesopic luminance conditions that represent real-world vision tasks at presentation times that simulate real-world fixations [9], and, as such, have demonstrated improved correlations with task performance under those conditions compared with chart measurements. Those with visual acuities below 20/100 were not tested or included.…”
“…Preferred Luminance-One can determine from a visual inspection of Figure 3 [2] that there is an appreciable difference between placebo and intervention groups in terms of change from baseline to 6 months, right and left eyes compared to the baseline data (t-test p = 0.02 and 0.03, respectively) using the simple clinical device and the statistical constraints imposed by post-randomization heterogeneity of variance.…”
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