Night Moves and Modes: Sleep Biomarkers for Neurocognitive Disorders

Grigg-Damberger, Madeleine; Damberger, Stanley J

doi:10.1097/wnp.0000000000000912

Journal of Clinical Neurophysiology

2022

DOI: 10.1097/wnp.0000000000000912

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Night Moves and Modes: Sleep Biomarkers for Neurocognitive Disorders

Madeleine Grigg-Damberger

Stanley J Damberger

Abstract: To serve patients and society by publishing and disseminating the highest quality clinical neurophysiology research and reviews to the medical community. Vision StatementTo optimize neurologic health through dissemination of contemporary clinical neurophysiology education and research.

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2024

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Multiscale neural dynamics in sleep transition volatility across age scales: a multimodal EEG-EMG-EOG analysis of temazepam effects

Sirpal,

Sikora,

Refai

2024

GeroScience

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Recent advances in computational modeling techniques have facilitated a more nuanced understanding of sleep neural dynamics across the lifespan. In this study, we tensorize multiscale multimodal electroencephalogram (EEG), electromyogram (EMG), and electrooculogram (EOG) signals and apply Generalized Autoregressive Conditional Heteroskedasticity (GARCH) modeling to quantify interactions between age scales and the use of pharmacological sleep aids on sleep stage transitions. Our cohort consists of 22 subjects in a crossover design study, where each subject received both a sleep aid and a placebo in different sessions. To understand these effects across the lifespan, three evenly distributed age groups were formed: 18–29, 30–49, and 50–66 years. The methodological framework implemented here employs tensor-based machine learning techniques to compute continuous wavelet transform time–frequency features and utilizes a GARCH model to quantify sleep signal volatility across age scales. Support Vector Machines are used for feature ranking, and our analysis captures interactions between signal entropy, age, and sleep aid status across frequency bands, sleep transitions, and sleep stages. GARCH model results reveal statistically significant volatility clustering in EEG, EMG, and EOG signals, particularly during transitions between REM and non-REM sleep. Notably, volatility was higher in the 50–66 age group compared to the 18–29 age group, with marked fluctuations during transitions from deep sleep to REM sleep (standard deviation of 0.35 in the older group vs. 0.30 in the 18–29 age group, p < 0.05). Statistical comparisons of volatility across frequency bands, age scales, and sleep stages highlight significant differences attributable to sleep aid use. Mean conditional volatility parameterization of the GARCH model reveals directional influences, with a causality index of 0.75 from frontal to occipital regions during REM sleep transition periods. Our methodological framework identifies distinct neural behavior patterns across age groups associated with each sleep stage and transition, offering insights into the development of targeted interventions for sleep regularity across the lifespan.

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Multiscale neural dynamics in sleep transition volatility across age scales: a multimodal EEG-EMG-EOG analysis of temazepam effects

Sirpal,

Sikora,

Refai

2024

GeroScience

View full text Add to dashboard Cite

show abstract

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Night Moves and Modes: Sleep Biomarkers for Neurocognitive Disorders

Abstract: To serve patients and society by publishing and disseminating the highest quality clinical neurophysiology research and reviews to the medical community. Vision StatementTo optimize neurologic health through dissemination of contemporary clinical neurophysiology education and research.

Cited by 1 publication

References 20 publications

Multiscale neural dynamics in sleep transition volatility across age scales: a multimodal EEG-EMG-EOG analysis of temazepam effects

Multiscale neural dynamics in sleep transition volatility across age scales: a multimodal EEG-EMG-EOG analysis of temazepam effects

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