Night melatonin levels affect cognition in diurnal animals: Molecular insights from a corvid exposed to an illuminated night environment

Buniyaadi, Amaan; Prabhat, Abhilash; Bhardwaj, Sanjay Kumar; Kumar, Vinod

doi:10.1016/j.envpol.2022.119618

Cited by 5 publications

(3 citation statements)

References 68 publications

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“…Among these, substantial literature indicates that humans display cognitive impairments owing to ALAN [4–6]. Similar effects have been reported for laboratory rodent models [7] and even more severe ones for wild avian populations, in which ALAN-mediated alterations in hormonal homeostasis hamper cognitive functioning [8–11] (but see [12]). Considering the often-reported influence of individuals’ cognitive abilities on fitness (e.g.…”

Section: Introductionmentioning

confidence: 66%

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Embryonic exposure to artificial light at night impairs learning abilities and their covariance with behavioural traits in teleost fish

Lucon-Xiccato,

De Russi,

Cannicci

et al. 2023

Biol. Lett.

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The natural light cycle has profound effects on animals' cognitive systems. Its alteration owing to human activities, such as artificial light at night (ALAN), affects the biodiversity of mammalian and avian species by impairing their cognitive functions. The impact of ALAN on cognition, however, has not been investigated in aquatic species, in spite of the common occurrence of this pollution along water bodies. We exposed eggs of a teleost fish (the zebrafish Danio rerio ) to ALAN and, upon hatching, we measured larvae’ cognitive abilities with a habituation learning paradigm. Both control and ALAN-exposed larvae showed habituation learning, but the latter learned significantly slower, suggesting that under ALAN conditions, fish require many more events to acquire ecologically relevant information. We also found that individuals' learning performance significantly covaried with two behavioural traits in the control zebrafish, but ALAN disrupted one of these relationships. Additionally, ALAN resulted in an average increase in larval activity. Our results showed that both fish's cognitive abilities and related individual differences are negatively impacted by light pollution, even after a short exposure in the embryonic stage.

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Section: Introductionmentioning

confidence: 66%

“…ALAN pollution affects a significant proportion of aquatic habitats [14][15][16][17], potentially exposing fish to the cognitive impairments associated with altered light-dark cycles described for land vertebrates [4,7,8]. We demonstrated that fish larvae from experimental populations exposed to ALAN exhibited reduced habituation learning.…”

Section: Discussionmentioning

confidence: 91%

Embryonic exposure to artificial light at night impairs learning abilities and their covariance with behavioural traits in teleost fish

Lucon-Xiccato,

De Russi,

Cannicci

et al. 2023

Biol. Lett.

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“…In this intricate process, the BDNF exhibited rhythmic expression patterns in the SCN and striatum. This signaling pathway may alter the sensitivity of the SCN pacemaker to light cues, thereby impacting mood regulation [47][48][49][50]. Additionally, the SCN regulated the circadian oscillation of the adenylyl cyclase/MAPK pathway [51].…”

Section: Discussionmentioning

confidence: 99%

Suprachiasmatic nucleus dysfunction induces anxiety- and depression-like behaviors via activating the BDNF-TrkB pathway of the striatum

Xie,

Ding

et al. 2024

Preprint

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The circadian rhythm system consists of a master clock located in the suprachiasmatic nucleus (SCN) of the hypothalamus and peripheral clocks dispersed throughout other brain areas (including striatum, Str) as well as various tissues and organs. Circadian rhythm disturbance is a major risk factor and common comorbidity for mood disorders, especially anxiety and depression. Bmal1 is one of the fundamental clock protein genes that is required to maintain circadian rhythm. Recent research has revealed a link between suprachiasmatic nucleus dysfunction and anxiety and depression, but the underlying mechanisms remain to be fully elucidated. This study aimed to investigate how circadian rhythm disturbance may lead to anxiety and depression-like behaviors. Through behavioral tests, virus tracing, molecular biology and other techniques, we found neural connection from the suprachiasmatic nucleus to the striatum. SCN lesions and Bmal1flox/flox+pAAV-hSyn-Cre-GFP (conditional knockout, cKO) mice exhibited disruptions in core body temperature rhythm, as well as anxiety- and depression-like behaviors. Importantly, these mice displayed altered expression patterns of clock protein genes and an upregulation of the Brain-Derived Neurotrophic Factor (BDNF) - Tyrosine Kinase receptor B (TrkB) signaling pathway within the striatum. Microinjection of the TrkB inhibitor ANA-12 can effectively reverse anxiety and depression-like behaviors. These findings indicate that suprachiasmatic nucleus dysfunction may contribute to the pathogenesis of anxiety and depression through upregulation of the BDNF-TrkB pathway in the striatum, potentially mediated by neural projections from the SCN. Bmal1 gene within SCN may represent a novel therapeutic target for mood disorders.

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Artificial night illumination disrupts sleep, and attenuates mood and learning in diurnal animals: evidence from behavior and gene expression studies in zebra finches

Kumar

Prabhat

Kumar

et al. 2023

Photochem Photobiol Sci

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Night melatonin levels affect cognition in diurnal animals: Molecular insights from a corvid exposed to an illuminated night environment

Cited by 5 publications

References 68 publications

Embryonic exposure to artificial light at night impairs learning abilities and their covariance with behavioural traits in teleost fish

Embryonic exposure to artificial light at night impairs learning abilities and their covariance with behavioural traits in teleost fish

Suprachiasmatic nucleus dysfunction induces anxiety- and depression-like behaviors via activating the BDNF-TrkB pathway of the striatum

Artificial night illumination disrupts sleep, and attenuates mood and learning in diurnal animals: evidence from behavior and gene expression studies in zebra finches

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