“…Tansley (1933) has shown that the concentration of visual purple m the retinas of rats and dogs, which have been subjected to a vitamin A deficient diet, is very low and ma} r be totally absent She (1931) previously had presented evidence which indicated that vitamin A is a precursor of visual purple, and that the amount of visual purple in the eye at any given 369 time is in part conditioned upon the amount of vitamin A present. Some investigators have used the relationship between the rate of recovery following stimulation with a bright light and vitamin A as a basis for detecting subclinical states of vitamin A deficiency (Jeans and Zentmire, 1934;Park, 1936;Jeans, Blanchard, and Zentmire, 1937;Jeghers, 1937;Hecht and Mandelbaum, 1939;Wald and Stevens, 1939) In the report of Jeans and Zentmire (1934), 21% of a group of 213 children were considered to be suffering from avitaminosis A On testing 275 adults, Park (1936) found two in a group considered to be vitamin A deficient who also experienced difficulties when driving at night due to the glare of the headlights of approaching cars Some of Jeghers' (1937) subjects also experienced similar difficulties On questioning those individuals who had long recovery times, several of them reported that they preferred not to do any night driving because of experiencing relatively long periods of blindness from the headlights of approaching cars In a later and more extensive study (1938) those subjects having difficulties in night driving were given large doses of vitamin A concentrates They all gained relief and could again drive at night with little ill effect from glaring headlights In these investigations the photometer or some adaptation of it was used, and the measure of the dark adaptation rate was the rate of change in the threshold for absolute intensity following stimulation with a very bright light. The present writers became interested in the relationship between glare weakness and vitamin A intake in connection with studies on the factors conditioning efficiency in automobile driving.…”