Nigella sativa seed extract: 1. Enhancement of sheep macrophage immune functions in vitro

Elmowalid, Gamal A.; Amar, Ahmad M.; Ahmad, Adel Attia M.

doi:10.1016/j.rvsc.2013.02.015

Cited by 26 publications

(26 citation statements)

References 31 publications

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“…In the current study, the improved nutrient intake in lambs fed the BCM150 diet could be related to improved DM, CP and EE digestibility, N retention ( Table 2) and/or a lower dustiness as a function of greater EE in the BCM150 diet vs the CON diet. Another explanation for these findings is due to the improvement in the gastrointestinal tract health [24], antimicrobial effects on the pathogenic microorganisms in the digestive system [25], to enhanced palatability [26] or improvement in immune system [19] or to reduced dustiness that was observed in the BCM150 diet compared with the CON diet. Enhanced nutrient intake in the current study is consistent with the observations of Abdel-Magid et al [8] when BCM was fed to crossbred calves at 53 or 106 g/kg of dietary DM.…”

Section: Discussionmentioning

confidence: 99%

The Inclusion of Black Cumin Meal Improves Growth Performance of Growing Awassi Lambs

Obeidat

2020

Veterinary Sciences

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Twenty-four Awassi lambs were randomly divided into two dietary treatments to assess the influence of black cumin meal (BCM; Nigella sativa L.) feeding on growth performance. Diets were no BCM (CON) or 150 g BCM/kg DM (BCM150)). Lambs were fed the experimental diets for 80 days. Lambs were housed randomly in individual pens that were fitted with water and feed containers. During the study, nutrient intake was measured daily. Body weight (BW) and average daily gain (ADG) were evaluated biweekly. Nutrient digestibility and nitrogen (N) balance were evaluated on days 49-59. Intakes of dry matter, crude protein (CP), neutral detergent fiber (NDF), acid detergent fiber (ADF), ether extract (EE) and metabolizable energy were greater (p ≤ 0.05) in the BCM150 diet than in the CON diet. The digestibility of DM, CP and EE (p ≤ 0.04) was improved in the BCM150 diet compared to the CON diet. However, NDF and ADF digestibility did not differ between the two diets. Nitrogen retained (g/d; p = 0.01) and N retention (%; p = 0.05) was greater in the BCM150 compared with CON diet. Final BW, ADG, and feed efficiency (DM intake: kg of gain) was greater (p ≤ 0.002) in BCM150 lambs than the CON lambs. However, cost/kg of BW gain was lower in the BCM150 diet than in the CON diet. In conclusion, the inclusion of black cumin meal improved the growth performance and profits in diets of growing lambs. Therefore, it could be used as an alternative to soybean meal and barley as a protein and energy supplement, respectively.

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Section: Discussionmentioning

confidence: 99%

The Inclusion of Black Cumin Meal Improves Growth Performance of Growing Awassi Lambs

Obeidat

2020

Veterinary Sciences

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“…Moreover, the innate immune system responds to infection by producing pro-inflammatory mediators such as TNF-␣ and IL-6 to activated macrophages kill intracellular pathogens by generating nitric oxide and reactive oxygen species (Gordon and Taylor, 2005;Matsusaka et al, 1993). Therefore, enhance macrophage functions may control infectious diseases in both human and veterinary medicine (Elmowalid et al, 2013;Wiege et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Macrophage migration is controlled by Tribbles 1 through the interaction between C/EBPβ and TNF-α

Liu¹,

Tan²,

Morrison³

et al. 2013

Veterinary Immunology and Immunopathology

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“…Thymoquinone (C 10 H 10 O 2 ; 2-isopropyl-5-methyl-1,4-benzoquinone; molecular weight 164.2) composes 27.8-57% of the volatile fatty acids of black cumin 3,4. In previous studies, many effects of TQ including antioxidant,5 anti-inflammatory,6 analgesic,7 anti-asthmatic,8 and antimicrobial9 effects were found, and a cell reproduction inhibitory effect in many types of cancer was also detected 10,11. It has very few documented side effects 12.…”

mentioning

confidence: 99%

Effects of thymoquinone, the major constituent of Nigella sativa seeds, on penicillin-induced epileptiform activity in rats

Beyazçiçek

Ankaralı

Beyazçiçek

et al. 2016

NSJ

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Objective:To investigate the effects of thymoquinone (TQ) in a penicillin-induced epilepsy model in rats.Methods:This experimental study included 56 adult male Wistar rats. Experiments were performed in the Research Laboratory of the Department of Physiology, Medical School, Duzce University, Duzce, Turkey, between October 2013 and December 2014. Animals were divided into the following 7 groups: sham, control, only thymoquinone, vehicle (Dimethylsulfoxide), and doses of 10, 50, and 100 mg/kg of TQ. After rats were anesthetized, the left part of the skull was removed. A pair of silver/silver chloride electrodes was placed on the somatomotor area, and electrocorticographic recording was started. After 5 minutes basal activity was recorded, and TQ was applied intraperitoneally. At the thirtieth minute after TQ, epileptiform activity was induced by intracortical penicillin. The first spike latency, spike frequency, and the amplitude of epileptiform activity were analyzed statistically.Results:The different doses of TQ significantly increased the latency time to onset of first spike wave, and decreased the frequency, and amplitude of epileptiform activity in the first 20 minutes compared with the control group.Conclusion:Thymoquinone shows potential as an antiepileptic drug resulting from its effects of prolonged latency time, and reduced spike wave frequency and amplitude of epileptiform activity.

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Nigella sativa seed extract: 1. Enhancement of sheep macrophage immune functions in vitro

Cited by 26 publications

References 31 publications

The Inclusion of Black Cumin Meal Improves Growth Performance of Growing Awassi Lambs

The Inclusion of Black Cumin Meal Improves Growth Performance of Growing Awassi Lambs

Macrophage migration is controlled by Tribbles 1 through the interaction between C/EBPβ and TNF-α

Effects of thymoquinone, the major constituent of Nigella sativa seeds, on penicillin-induced epileptiform activity in rats

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