Nigella Sativa reverses osteoporosis in ovariectomized rats

Seif, Ansam Aly

doi:10.1186/1472-6882-14-22

Cited by 35 publications

(33 citation statements)

References 42 publications

(49 reference statements)

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“…These changes were reversed by NS supplementation in OVX-NS group to be near-normal levels in addition to that histological changes were also noticed on tibia in OVX-NS rats [16]. These results reported also in studies that been used rabbits [20,21].…”

Section: Resultssupporting

confidence: 79%

“…We recorded the following data from the studies: (1) the type of study, (2) a brief description of the sample/population of the study; (3) a brief description of the methods used in the study; (4) the brief description of the results of the study; (5) comments and conclusion of the study; (6) complications if any. All studies were animal experimental studies and have been conducted either on rats or rabbits [15][16][17][18][19][20][21]. Information of these studies is summarized in the Table 2.…”

Section: Resultsmentioning

confidence: 99%

“…The parameters that have been determined in rat studies were different such as serum alkaline phosphatase (ALP) level, radiological, histological, immunohistochemical, and morphometrical studies [15], other study measured plasma levels of calcium (Ca +2 ), phosphorous (Pi), ALP, amino terminal collagen Type 1 telopeptide, malondialdehyde (MDA), nitrates, nitric oxide surrogate, tumor necrosis factor-α (TNF-α), and interleukin-6 (IL-6) in addition to istomorphometric analysis of the tibia [16]. Moreover, systemic quantitative measurement for new bone formation, osteoblast lining, and semi-quantitative measurement of capillary intensities were examined in another study [18].…”

Section: Resultsmentioning

confidence: 99%

“…Several experimental studies have been conducted to study the effect of NS as a whole or only its major component TQ reported that NS and/or TQ have beneficial effects on osteoporosis and bone healing [15][16][17][18][19][20][21]. Besides that, some few review articles that have surveyed the effect of NS on osteoporosis and bone healing.…”

Section: Osmanmentioning

confidence: 99%

“…Seif, 2014 [16], objected to elucidate the protective effect of NS on osteoporosis produced by ovariectomy in rats as a model of postmenopausal osteoporosis. She reported that ovariectomy rats showed significant decrease in plasma Ca…”

Section: Nilmentioning

confidence: 99%

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Nigella Sativa Has Beneficial Effect on Osteoporosis and Bone Healing. Is It Fact or Fiction? A Systematic Review

Osman

2017

Asian J Pharm Clin Res

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Osteoporosis is the most common reason for a broken bone among the elderly. Several experimental studies have been reported that Nigella sativa (NS) and/or its major component thymoquinone (TQ) have good effects on osteoporosis and bone healing. We conducted this systematic review to evaluate these relevant studies to prove whether NS and/or TQ has potential effect on osteoporosis and can stop pathogenesis of this disease or this matter still just a fiction. A search on published studies was done using databases including Scopus, PubMed, Google Scholar, Web of Science, and CINAHIL. Terms searched included "Nigella sativa, black seed, TQ, osteoporosis, bone healing." Initially, 213 articles were extracted. After reviewing their titles and abstracts, 124 articles (Medline, 43; Scopus, 67; EBSCO, 14) were retrieved for further evaluation. However, after excluding the clinical trial studies, human reviews, removal of abstracts and unrelated studies, seven studies were considered finally as eligible for our review. Finally, seven studies were considered eligible for our review. The total number of animals used was 220 (150 rats and 70 rabbits) from different experimental study. Based on the results of this systematic review, we conclude that NS or TQ extract therapy for osteoporosis cannot be recommended yet and these data will not suffice to exclude the beneficial effects of NS on bone turnover reliably. Therefore, more studies are required to explore the specific cellular and molecular targets of NS or TQ using animal osteoporosis models. Once the anti-osteoporotic effectiveness of NS or TQ will be established, human studies can be carried out.

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Section: Resultssupporting

confidence: 79%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Osmanmentioning

confidence: 99%

Section: Nilmentioning

confidence: 99%

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Nigella Sativa Has Beneficial Effect on Osteoporosis and Bone Healing. Is It Fact or Fiction? A Systematic Review

Osman

2017

Asian J Pharm Clin Res

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Efficacy of nanomicelle curcumin,Nigella sativaoil, and their combination on bone turnover markers and their safety in postmenopausal women with primary osteoporosis and osteopenia: A triple‐blind randomized controlled trial

Kheiridoost

Shakouri

Shojaei‐Zarghani

et al. 2021

Food Science & Nutrition

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Literature supports the potential effects of nanomicelle curcumin and Nigella sativa on the amelioration of osteoporosis, a health concern of postmenopausal women. This study aimed to evaluate the impacts of nanomicelle curcumin (CUR), Nigella sativa oil (NS), and their combination on bone turnover biomarkers and assess their safety. This triple‐blind randomized controlled trial was performed on 120 postmenopausal women aged 50–65 with primary osteoporosis or osteopenia. The subjects were randomly allocated to receive microcrystalline cellulose (placebo), 80 mg of CUR, 1000 mg of NS, or their combination (CUR‐NS) for 6 months. All patients were also treated with alendronate (70 mg) and calcium (500 mg), vitamin D (400 IU) supplements. The serum levels of alkaline phosphatase (ALP), osteocalcin (OC), and osteopontin (OP) were measured at the baseline and after the intervention. For safety assessment, the hepatic enzyme levels of aspartate transaminase and alanine transaminase as well as serum urea and creatinine were evaluated. ALP levels were significantly reduced in the NS (p = .029) and CUR‐NS (p = .015) groups compared with those in the placebo. After adjustment for the covariates, this effect was still significant in the CUR‐NS group (p = .004). The OC levels were decreased in the placebo, CUR, and NS groups, and the OP concentration also was attenuated in all groups through the trial. However, the intergroup differences were not significant for both biomarkers. Evaluating the key renal metabolites and hepatic enzyme levels indicated no toxicity of the administered doses. This study reveals the beneficial effects of CUR‐NS on the improvement of some bone turnover biomarkers. These compounds seem to be safe at the current dosage for supplementation in postmenopausal women.

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Antiosteoporosis effect of geraniin on ovariectomy‐induced osteoporosis in experimental rats

Wang

Cui

et al. 2021

J Biochem & Molecular Tox

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Osteoporosis is a skeletal condition that is characterized by decreasing bone density and deteriorating bone mass. The plant-based phytoconstituent such as geraniin possesses better therapeutic potentials in biomedical field. In the current experimental study, we planned to scrutinize the therapeutic potential of geraniin against ovariectomy (OVX)-induced osteoporosis in rats and find the possible mechanism.Healthy Sprague Dawley rats were randomized into six groups and subjected to geraniin and alendronate (ALN) treatment for 10 weeks. Body weight, uterus, femur weight, bone biochemical, bone turnover markers, inflammatory cytokine, calcium, phosphorus, vitamin D (Vit D), urine, hormones, and antioxidant level were estimated. Geraniin significantly (p < .001) reduced the level of bone turnover markers including beta-CrossLaps (β-CTx), ALN, osteocalcin (OC), alkaline phosphatase (ALP), and bone Gla protein (BGP); reduced the biomechanical parameters including maximum load, energy, stiffness, maximum stress, and Young's modulus; reduced the level of calcium (Ca) and phosphorus (P); and increased the level of vitamin D (Vit D) as compared with OVX-induced osteoporosis rats. Geraniin increased the level of bone structure parameters, namely bone mineral density, bone mineral content, tissue mineral density, bone volume fraction, and trabecular number; increased the level of osteoprotegerin (OPG) and OPG/RANKL; and reduced the level of receptor activator of nuclear factor kappa-Β ligand (RANKL). Geraniin significantly (p < .001) increased the level of glutathione (GSH) and reduced the level of malonaldehyde (MDA) in the liver, intestine, and bone of OVX-induced osteoporosis rats. Geraniin significantly (p < .001) decreased the level of tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and interleukin-6 (IL-6) pro-inflammatory cytokines.We also argue that geraniin could be an excellent candidate to treat and control bone-related disease or disorders.

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Nigella Sativa reverses osteoporosis in ovariectomized rats

Cited by 35 publications

References 42 publications

Nigella Sativa Has Beneficial Effect on Osteoporosis and Bone Healing. Is It Fact or Fiction? A Systematic Review

Nigella Sativa Has Beneficial Effect on Osteoporosis and Bone Healing. Is It Fact or Fiction? A Systematic Review

Efficacy of nanomicelle curcumin,Nigella sativaoil, and their combination on bone turnover markers and their safety in postmenopausal women with primary osteoporosis and osteopenia: A triple‐blind randomized controlled trial

Antiosteoporosis effect of geraniin on ovariectomy‐induced osteoporosis in experimental rats

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