Nigella sativa inhibits intestinal glucose absorption and improves glucose tolerance in rats

Meddah, Bouchra; Ducroc, Robert; Faouzi, My El Abbés; Eto, Bruno; Mahraoui, Lahcen; Benhaddou-Andaloussi, Ali; Martineau, Louis C.; Cherrah, Yahia; Haddad, Pierre S.

doi:10.1016/j.jep.2008.10.040

Cited by 174 publications

(102 citation statements)

References 27 publications

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“…In another experiment, oral treatment with aqueous extract of N. sativa for 6 weeks (2 g/kg daily) in normal rats, improved glucose tolerance as efficiently as metformin (300 mg/kg daily). It also reduced body weight without any toxic effect [37]. Le et al gave petroleum ether extract of N. sativa seeds to normal rats for four weeks; it caused a 25% reduction in food intake that translated into a transient weight loss.…”

Section: Antidiabetic Activity In Normal Ratsmentioning

confidence: 99%

“…Le et al demonstrated that in vivo treatment with petroleum ether extract of N. sativa, resulted in greater dose-dependent activation of MAPK p44/42erk and PKB in response to insulin in hepatocytes, which suggests that in vivo treatment with N. sativa extract exerts an insulin-sensitizing action by enhancing the activity of the two major intracellular signal transduction pathways of the hormone's receptor [38]. Intestinal absorption of glucose is also lowered by N. sativa as evidenced by the fact that the aqueous extract of N. sativa (0.1 pg/ml to 100 ng/ ml) exerted dose-dependent inhibition of sodium-dependent glucose transport across isolated rat jejunum [37]. It appears that antidiabetic activity of N. sativa is mediated via multiple modes of actions [61].…”

Section: Possible Mechanisms Of Antidiabetic Activitymentioning

confidence: 99%

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Antidiabetic Properties of a Spice Plant Nigella sativa

Mathur

2011

J Endocrinol Metab

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Seeds of Nigella sativa (black cumin/kalonji) used in pickles as spice, have also been traditionally used in treatment of many diseases including diabetes and hypertension. Among many activities exhibited by N. sativa and its constituents in animal experiments, antidiabetic property is most important. Thymoquinone (TQ), a volatile oil, is one of its active constituents but antidiabetic activity has also been shown by its aqueous extract and defatted extract. N. sativa may be beneficial in diabetic individuals and those with glucose intolerance as it reduces appetite, glucose absorption in intestine, hepatic gluconeogenesis, blood glucose level, cholesterol, triglycerides, body weight and simulates glucose induced secretion of insulin from beta-cells in pancreas; improves glucose tolerance as efficiently as metformin; yet it has not shown significant adverse effects and has very low toxicity. In streptozotocin (STZ) induced diabetic rats it causes gradual partial regeneration of pancreatic beta-cells, increases the lowered serum insulin concentrations and decreases the elevated serum glucose. N. sativa has antioxidant activity and protective role of TQ against development of type I diabetes may be via NO inhibitory pathway. It also exerts an insulin-sensitizing action in hepatocytes. Seeds of N. sativa have been safely consumed by human patients in many clinical trials which however were not aimed to assess its antidiabetic activity. In future clinical studies may show potential of N. sativa, its constituents or their synthetic analogues, in prevention and control of diabetes.

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Section: Antidiabetic Activity In Normal Ratsmentioning

confidence: 99%

Section: Possible Mechanisms Of Antidiabetic Activitymentioning

confidence: 99%

Antidiabetic Properties of a Spice Plant Nigella sativa

Mathur

2011

J Endocrinol Metab

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“…The present results concerned the hypoglycemic effect of plant mixture agrees with those reported the antidiabetic effect of Turmeric rhizomes in alloxan induced diabetic rats (Shnkar et al, 1980) and with others (Haddad et al, 2003;Labhal et al, 1997;El-Bagir et al, 2010) that demonstrated the hypoglycemic effect of Black cumin seed. The antidiabetic effect of Turmeric perhaps attributed to the antioxidant activity of curcumin against oxidative tissue damage (Joe and Lokesh, 1994) whereas, the antidiabetic effect of Black cumin seed perhaps explained by an insulin-like stimulation of glucose uptake by muscle and adipose tissue (Benhaddou-Andaloussi et al, 2010) or inhibition of intestinal glucose absorption (Meddah et al, 2009). …”

Section: Discussionmentioning

confidence: 99%

“…Turmeric powder was mixed with distilled water (Meddah et al, 2009;Mills and Bone 2000). The Black cumin seed was used in a dose of 1 g/kg body weight and mixed with Turmeric powder in a dose of 0.5 g/kg body weight.…”

Section: Preparation Of Plant Suspensionmentioning

confidence: 99%

“…The Black cumin seed was used in a dose of 1 g/kg body weight and mixed with Turmeric powder in a dose of 0.5 g/kg body weight. The dose used in the current experiment was the half of the doses used in previous works for Black cumin seed (Labhal et al, 1997;Le et al, 2004;Meddah et al, 2009) and Turmeric (Arun and Nalini 2002) because plants were used in a combination.…”

Section: Preparation Of Plant Suspensionmentioning

confidence: 99%

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Influence of Combined Administration of Turmeric and Black seed on Selected Biochemical Parameters of Diabetic Rats

El-Bahr¹,

Taha²,

Korshom³

et al. 2014

AJVS

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Key wordsABSTRACT: Diabetes mellitus, blood glucose, body weight, water intake, food intake.The objective of the present study was to investigate the effect of Turmeric (Curcuma Longa) and Black cumin seed (Nigella Sativa) mixture on selected biochemical parameters of streptozotocin (STZ) induced diabetic rats. Therefore, twenty one healthy adult albino rats divided into three groups (7 rats in each). Rats of first and second groups were non diabetic and diabetic respectively. Rats of the third group were diabetic and received a mixture of Turmeric (0.5 g/kg b .wt.) and Black cumin seed (1 g/kg b.wt.) orally by intragastric intubations once a day for six weeks. The changes in blood glucose level, body weight and water and food intake were measured. In addition, selected biochemical parameters were also determined. The present study revealed that, dietary supplementation of plant mixture of Turmeric and Black cumin seed to diabetic rats significantly (P<0.05) reduced the blood glucose level as well as water and food intake accompanied by an increase in body weight gain when compared with untreated diabetic rats. Proteins were not affected whereas liver and kidney functions were disrupted in STZ-diabetic rats and restored whenever treated by medicinal plants mixture. Hypercholesterolemia and hyperlipidemia observed in STZdiabetic rats were attenuated by administration of examined medicinal plants combination. Conclusively, dietary supplementation of Turmeric and Black cumin seed mixture reduced blood glucose level and ameliorated the hypercholesterolemia and hyperlipidemia in STZ induced diabetic rats.

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Nutritional Features and Bioactivities of Thymoquinone against Type 2 Diabetes Mellitus

Atukeren

2023

Natural Products and Their Bioactives in Antidiabetic Drug Discovery

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Nigella sativa inhibits intestinal glucose absorption and improves glucose tolerance in rats

Cited by 174 publications

References 27 publications

Antidiabetic Properties of a Spice Plant Nigella sativa

Antidiabetic Properties of a Spice Plant Nigella sativa

Influence of Combined Administration of Turmeric and Black seed on Selected Biochemical Parameters of Diabetic Rats

Nutritional Features and Bioactivities of Thymoquinone against Type 2 Diabetes Mellitus

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