“…Compared with the large majority of investigations evaluating the in silico potential of plant metabolites, few studies reported in vitro anti-SARS-CoV-2 activity of plant extracts (Nair et al, 2022; Chen et al, 2023; De Araujo et al, 2023; Farooq et al, 2024; Kakimoto et al, 2024; Rodrigues et al, 2024). Certain plants with a long history of use in traditional medicine systems to manage flu syndromes, as for example Withania somnifera (L.) Dunal, Andrographis paniculata (Burm.F) Wall.ex Nees, Echinacea purpurea (L.) Moench, Artemisia annua and Nigella sativa L., have shown to be promising candidates in the search for an effective preventive or curative treatment of COVID-19 (Kolev et al, 2022; Nair et al, 2022; Nicolussi et al, 2022; Cyril et al, 2023; Ramli et al, 2023; Shanker et al, 2023).…”