Nigella damascena L. Essential Oil—A Valuable Source of β-Elemene for Antimicrobial Testing

Sieniawska, Elwira; Sawicki, Rafał; Golus, Joanna; Swatko-Ossor, Marta; Ginalska, Grażyna

doi:10.3390/molecules23020256

Cited by 31 publications

(15 citation statements)

References 31 publications

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“…In our search for new compounds of possible pharmaceutical interest, we previously carried out chemical investigations of male and female S. molle (L.) fresh leaf extracts and they were shown to be mainly composed of sesquiterpene hydrocarbons and monoterpene hydrocarbons [33]. We found the presence of molecules-such as elemol, β-elemene, β-caryophyllene, germacrene D, bicyclogermacrene, spathulenol, α-eudesmol, β-eudesmol, γ-eudesmol, isocalamendiol, sabinene and n-hexadecanoic acid-that could be related to possible antibacterial, antiviral and antifungal activities, as already reported in literature [34][35][36][37][38][39][40][41][42][43][44][45].…”

Section: Introductionsupporting

confidence: 80%

Antimicrobial Testing of Schinus molle (L.) Leaf Extracts and Fractions Followed by GC-MS Investigation of Biological Active Fractions

et al. 2020

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Schinus molle (L.) is a dioecious plant of the Anacardiaceae family, originating in South America and currently widespread in many regions throughout the world. In this work leaf extracts and derived low-pressure column chromatography (LPCC) fractions of S. molle L. male and female plants were investigated for the antimicrobial activity. Leaf extracts were tested on microbes Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, Enterococcus faecalis, Candida albicans and Bacillus subtilis. Furthermore, the extracts showing antimicrobial activity were fractionated by LPCC and the obtained fractions tested on the same microorganism strains. Positive fractions were investigated by gas-chromatography/mass spectrometry (GC-MS) and were seen to be rich in sesquiterpenes, sesquiterpenoids and other terpens. The obtained effects highlighted the antimicrobial properties of S. molle (L.) leaf compounds and revealed their importance as a source of bioactive molecules of potential pharmaceutical interest. To our knowledge, this is the first paper reporting investigations on the chemical composition of the extracts and derived positive fractions from Schinus molle (L.) plants grown in central Italy

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Section: Introductionsupporting

confidence: 80%

Antimicrobial Testing of Schinus molle (L.) Leaf Extracts and Fractions Followed by GC-MS Investigation of Biological Active Fractions

et al. 2020

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“…Currently, Curcuma wenyujin , belonging to the Zingiberaceae family, is the plant most applied to the extraction of β-elemene [ 44 ]. Our results suggest that jabuticabas, mainly the ‘Esalq’ and ‘Escarlate’ species, are a natural source of this compound, which displays the potential to be used as a raw material for its extraction, as reported for Nigella damascena [ 45 ].…”

Section: Resultsmentioning

confidence: 63%

Volatile Compounds and Physicochemical Quality of Four Jabuticabas (Plinia sp.)

et al. 2020

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The jabuticaba is a native Brazilian fruit that has aroused worldwide interest in terms of its nutritional composition and biological activity. However, research on the profile of volatile compounds (VOCs) emitted by these fruits is rare. This study presents the first identification of VOCs from four jabuticaba species. The aim of the study was to characterize the aromatic profile of the following species: ‘Sabará’ (Plinia jaboticaba), ‘Escarlate’ (Plinia phitrantha × Plinia cauliflora), ‘Otto Andersen’ (Plinia cauliflora), and ‘Esalq’ (Plinia phitrantha). The analysis was performed by headspace solid-phase microextraction combined with gas chromatography/mass spectrometry (SPME-GC-MS). Multivariate analysis techniques applying the partial least squares-discriminant analysis (PLS-DA) and heatmap were used to compare the results. Fruit quality parameters were determined in terms of fresh mass (g), skin color, soluble solids, and titratable acidity. A total of 117 VOCs was identified including terpenoids, esters, alcohols, aldehydes, alkanes, ketones, and carboxylic acids, with 36 VOCs common to all four species. Terpenes were the majority for all jabuticabas with smaller contributions from other volatile classes, especially β-cubebene, β-elemene, and D-limonene for the ‘Otto Andersen’ jabuticaba.

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“…127 Other EOs showing efficacy in studies against MDR-and XDR-TB are Myrtus communis L. 128 and Nigella damascena. 129 Our study showed LVO is a promising antimicrobial extract, which can be used in combinatory therapy and may possibly be effective in reviving the efficacy of carbapenem and other antibiotics against other resistant bacteria. We propose the overall mode of action of LVO: disrupting the bacterial membrane via oxidative stress.…”

Section: Mdr and Xdr Tuberculosismentioning

confidence: 67%

Multidrug and Pan-Antibiotic Resistance—The Role of Antimicrobial and Synergistic Essential Oils: A Review

Boren¹,

Crown²,

Carlson³

2020

Natural Product Communications

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Bacterial resistance to antibiotics continues to be a grave threat to human health. Because antibiotics are no longer a lucrative market for pharmaceutical companies, the development of new antibiotics has slowed to a crawl. The World Health Organization reported that the 8 new bacterial agents approved since July 2017 had limited clinical benefits. While a cohort of biopharmaceutical companies recently announced plans to develop 2-4 new antibiotics by 2030, we needn’t wait a decade to find innovative antibiotic candidates. Essential oils (EOs) have long been known as antibacterial agents with wide-ranging arsenals. Many are able to penetrate the bacterial membrane and may also be effective against bacterial defenses such as biofilms, efflux pumps, and quorum sensing. EOs have been documented to fight drug-resistant bacteria alone and/or combined with antibiotics. This review will summarize research showing the significant role of EOs as nonconventional regimens against the worldwide spread of antibiotic-resistant pathogens. The authors conducted a 4-year search of the US National Library of Medicine (PubMed) for relevant EO studies against methicillin-resistant Staphylococcus aureus, multidrug-resistant (MDR) Escherichia coli, EO combinations/synergy with antibiotics, against MDR fungal infections, showing the ability to permeate bacterial membranes, and against the bacterial defenses listed above. EOs are readily available and are a needed addition to the arsenal against resistant pathogens.

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Nigella damascena L. Essential Oil—A Valuable Source of β-Elemene for Antimicrobial Testing

Cited by 31 publications

References 31 publications

Antimicrobial Testing of Schinus molle (L.) Leaf Extracts and Fractions Followed by GC-MS Investigation of Biological Active Fractions

Antimicrobial Testing of Schinus molle (L.) Leaf Extracts and Fractions Followed by GC-MS Investigation of Biological Active Fractions

Volatile Compounds and Physicochemical Quality of Four Jabuticabas (Plinia sp.)

Multidrug and Pan-Antibiotic Resistance—The Role of Antimicrobial and Synergistic Essential Oils: A Review

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