Nifedipine-induced acute generalized exanthematous pustulosis in a case of acute glomerulonephritis

Acute generalized exanthematous pustulosis: atypical presentations and outcomes

“…However, all clinical presentations of DIHS include end organ involvement, with possible renal, hepatic, cardiac or neurologic damage, which can be life threatening . AGEP‐DIHS overlap occurs most commonly in association with anti‐epileptics such as carbamazepineand phenytoin and has also been described with allopurinol . DIHS with features of AGEP have also been found in association with ibuprofen and mexiletine .…”

“…Specifically, sulfa medications have been reported to produce AGEP in oval erythematous and edematous plaques with pinpoint pustules . In addition, AGEP has been described with other atypical medication triggers including anti‐hypertensives (atenolol, nifedipine and diltiazem), antimycotics (terbinafineand itraconazole) antibiotics (minocycline, sulfapyridine and clindamycin), paracetamol, allopurinol, anti‐inflammatory medications (corticosteroids and oxicam NSAIDs, hydroxychloroquine, dexamethasone), icodextran (a peritoneal dialysate), and intravenous radiocontrast media . We highlight these medications to alert the clinician to the possibility of AGEP with atypical medication triggers.…”