Nifedipine increases fetoplacental perfusion

Karahanoğlu, Ertuğrul; Altınboğa, Orhan; Akpınar, Funda; Demirdağ, Erhan; Özdemirci, Şafak; Akyol, Alpaslan; Yalvaç, Serdar

doi:10.1515/jpm-2016-0072

Cited by 6 publications

(6 citation statements)

References 17 publications

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“…In a previous study on nifedipine and fetoplacental perfusion, nifedipine is shown to increase fetoplacental perfusion 19 . However, there was no control group in this study for a comparison to be made.…”

Section: Discussionmentioning

confidence: 80%

“…There are a limited number of studies that evaluate the effects of maternal nifedipine treatment on fetoplacental blood flow in maternal uterine arteries and fetal umbilical arteries. Some studies demonstrate that the maternal uterine artery and fetal umbilical artery RI values did not change significantly 48 hours after nifedipine treatment, but some studies indicate that the uterine artery RI values did change significantly 11 19 20 . Such a difference may be due to the use of different doses of nifedipine in the studies.…”

Section: Discussionmentioning

confidence: 99%

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Effect of Nifedipine Used in the Treatment of the Threat of Preterm Labor on Total Uterine Artery Blood Volume Flow Rate

Eroğlu¹,

Turğal²,

Altınboğa³

et al. 2023

Z Geburtshilfe Neonatol

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Purpose Evaluation of the effect of maternal nifedipine treatment on total uterine artery blood volume flow rate (TVFR). Methods In this prospective study, 43 women who were admitted to the Perinatology Department of the University of Health Sciences Etlik Zübeyde Hanım Gynecology Training and Research Hospital, with the diagnosis of the threat of preterm labor, and 40 healthy pregnant women, who were randomly selected as the control group, were evaluated between July 1, 2018, and September 1, 2018. A transabdominal ultrasound examination of uterine arteries was performed both before and 48 hours after administration of oral nifedipine for TVFR measurement. For the final analysis, the TVFR levels of the group diagnosed with the threat of preterm labor and the control group were compared. Results There was no significant difference in either uterine artery pulsatility index or resistance index values as well as the diameters of the uterine arteries after nifedipine treatment (p>0.05 for all). Total uterine artery blood volume flow rate (TVFR) was 424.66±236.74 mL/min before and 543.39±309.68 mL/min after treatment with nifedipine and was statistically significantly higher (p < 0.05). ConclusionsOur study showed a statistically significant increase in total uterine artery blood volume flow rate 48 hours after oral nifedipine treatment.

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Section: Discussionmentioning

confidence: 80%

Section: Discussionmentioning

confidence: 99%

Effect of Nifedipine Used in the Treatment of the Threat of Preterm Labor on Total Uterine Artery Blood Volume Flow Rate

Eroğlu¹,

Turğal²,

Altınboğa³

et al. 2023

Z Geburtshilfe Neonatol

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“…17 Our data showed that nifedipine tocolysis produced no differences in the umbilical arteries Doppler (RI and PI) or in the MCA to umbilical artery ratio, similar to the findings of Karahanoglu et al who found that RI, the PI and the S/D ratio of UA did not change after treatment with nifedipine. 18 Also, de Heus et al showed that over the 5-day study period. The use of tocolytics did not significantly alter the time courses of PI-values for UA (p=0.37).…”

Section: Discussionmentioning

confidence: 99%

Assessment of Maternal Nifedipine as a Tocolytic Agent on the Doppler Indices of Uterine and Fetal Umbilical and Middle Cerebral Arteries

Abdellateef¹,

Shorbagy²,

Hagras³

et al. 2017

Gynecol Obstet Res Open J

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CitationAbdellateef SS, El Shorbagy SH, Hagras AM, Ghareeb AE. Assessment of maternal nifedipine as a tocolytic agent on the Doppler indices of uterine and fetal umbilical and middle cerebral arteries. This study was designed to assess the effects of maternal nifedipine administration on blood flow resistance in uterine, umbilical and fetal middle cerebral arteries by evaluating resistance index (RI) and pulsatility index (PI). Patients and Methods: This was a prospective, observational, analytic cohort study performed in 50 pregnant women undergoing nifedipine tocolysis, all women with a singleton pregnancy between 24 and 34 weeks of gestation, each subject acting as her own control. Doppler assessment of uterine, umbilical and fetal middle cerebral (MCA) arteries was performed before and 24 h and 72 h after an initial 20 mg oral dose, which was repeated at 20 min intervals if contractions failed to diminish up to a total maximum dose of 60 mg. The maintenance dose consisted of 20 mg orally every 6 h. We analyzed whether there was a time effect and compared values at the different time-points. Results: The research showed that the UtA-RI has increased significantly after 24 h and after 72 h of nifedipine administration (0 h=0.53; 24 h=0.56; 72 h=0.55; p=0.002, p=0.015 respectively). The MCA-RI had decreased significantly after 24 h (p=0.003) of tocolysis returning to baseline after 72 h (0 h=0.75; 24 h=0.73; 72 h=0.74; p=0.150). The MCA-PI had decreased significantly after 24 h (P=0.024) of tocolysis returning to baseline between 24 h and 72 h (0 h=1.85; 24 h=1.75; 72 h=1.79; p=0.204), with no differences in UtA-PI or in the umbilical arteries Doppler (RI & PI) or in the MCA to umbilical artery ratio. Conclusions: Nifedipine tocolysis is associated with a reduction in RI and PI in the MCA, and an increase in RI in uterine arteries after 24 h but returning to baseline within 72 h, with no long-term effect on fetomaternal circulation in pregnant women at risk of preterm delivery.

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“…The results of some authors have shown that chronic hypertension in pregnant women does not increase the risk of the occurrence of FGR [6]. Furthermore, calcium channel blockers have been identified as predictors of SGA in some studies [7], whereas no statistically significant association has been found between calcium channel blocker use during pregnancy and low birth weight infants in another study [8]. In light of these unknowns and the great clinical significance of the problem of FGR and SGA newborns, the aim of our study was to identify risk factors that contribute to the occurrence of FGR and SGA and quantify the strength of their impact.…”

Section: Introductionmentioning

confidence: 99%

Factors associated with fetal growth restriction and small for gestational age newborns

et al. 2022

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Nifedipine increases fetoplacental perfusion

Abstract: Although nifedipine had no effect on the PI, the RI or the S/D, it increased the mean pressure gradient, the VTI and FPP.

Cited by 6 publications

References 17 publications

Effect of Nifedipine Used in the Treatment of the Threat of Preterm Labor on Total Uterine Artery Blood Volume Flow Rate

Effect of Nifedipine Used in the Treatment of the Threat of Preterm Labor on Total Uterine Artery Blood Volume Flow Rate

Assessment of Maternal Nifedipine as a Tocolytic Agent on the Doppler Indices of Uterine and Fetal Umbilical and Middle Cerebral Arteries

Factors associated with fetal growth restriction and small for gestational age newborns

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