Nifedipine Gastrointestinal Therapeutic System versus Nifedipine Coat-Core: Comparison of Efficacy via 24-Hour Ambulatory Blood Pressure Monitoring

DeFina, Laura F.; Bookstaver, David A.; Goldfinger, Michael; Coffey, Timothy A.

doi:10.1177/106002809703100701

Cited by 6 publications

(3 citation statements)

References 10 publications

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“…Despite the total sample size of this pilot study, although by far greater than that of all previous chronotherapy trials with CCBs (Hermida & Smolensky, 2004;Hermida et al, 2005), an advantage of this study over previous studies (Defina et al, 1997;Mancia et al, 2002;Seki et al, 2005) is the fact that morning and evening administration time-dependent differences in BP control were explored. Further advantages include the use of 48 h sampling as opposed to the more common 24 h sampling of BP by ABPM and the use of wrist actigraphy to determine the diurnal and nocturnal means of BP for each patient according to the individual sleep-wake time.…”

Section: Discussionmentioning

confidence: 83%

“…This avoids high peak plasma levels during the first hours after dosing (Grundy & Foster, 1996;Zanchetti, 1994), which have been associated with various adverse effects, such as tachycardia, flushing, and headache (Leenen, 1996). This sustained release form of nifedipine is recommended for once-daily dosing, assumingly providing proper blood pressure (BP) control throughout the 24 h. Indeed, several studies have used ambulatory BP monitoring (ABPM) to investigate the effects of this once-daily (usually morning ingestion) formulation of nifedipine GITS on the circadian pattern of BP (Defina et al, 1997;Mancia et al, 2002;Seki et al, 2005).…”

Section: Introductionmentioning

confidence: 98%

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Dose‐ And Administration Time‐Dependent Effects Of Nifedipine Gits On Ambulatory Blood Pressure In Hypertensive Subjects

Hermida

Calvo

Ayala

et al. 2007

Chronobiology International

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Previous chronotherapy studies have shown that the circadian pattern of blood pressure (BP) remains unchanged after either morning or evening dosing of several calcium channel blockers (CCB), including amlodipine, isradipine, verapamil, nitrendipine, and cilnidipine. This trial investigated the antihypertensive efficacy and safety profile of the slow-release, once-a-day nifedipine gastrointestinal therapeutic system (GITS) formulation administered at different times with reference to the rest-activity cycle of each participant. We studied 80 diurnally active subjects (36 men and 44 women), 52.1+/-10.7 yrs of age, with grade 1-2 essential hypertension, who were randomly assigned to receive nifedipine GITS (30 mg/day) as a monotherapy for eight weeks, either upon awakening in the morning or at bedtime at night. Patients with uncontrolled BP were up-titrated to a higher dose, 60 mg/day nifedipine GITS, for an additional eight weeks. BP was measured by ambulatory monitoring every 20 min during the day and every 30 min at night for 48 consecutive hours before and after therapy with either dose. The BP reduction after eight weeks of therapy with the lower dose of 30 mg/day was slightly, but not significantly, larger with bedtime dosing. The efficacy of 60 mg/day nifedipine GITS in non-responders to the initial 30 mg/day dose was twice as great with bedtime as compared to morning dosing. Moreover, bedtime administration of nifedipine GITS reduced the incidence of edema as an adverse event by 91%, and the total number of all adverse events by 74% as compared to morning dosing (p=0.026). Independent of the time of day of administration, a single daily dose of 30 mg/day of nifedipine GITS provides full 24 h therapeutic coverage. The dose-dependent increased efficacy and the markedly improved safety profile of bedtime as compared to morning administration of nifedipine GITS should be taken into account when prescribing this CCB in the treatment of essential hypertension.

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Section: Discussionmentioning

confidence: 83%

Section: Introductionmentioning

confidence: 98%

Dose‐ And Administration Time‐Dependent Effects Of Nifedipine Gits On Ambulatory Blood Pressure In Hypertensive Subjects

Hermida

Calvo

Ayala

et al. 2007

Chronobiology International

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“…In the most recent study, Nif-GITS and Nif-CC were compared over 24 hours. 19 Only patients taking one antihypertensive drug were included. In this crossover study, blood pressure was compared at 4-hour intervals.…”

Section: Discussionmentioning

confidence: 99%

Comparison of 24‐Hour Ambulatory Blood Pressure Data in Hypertensive Patients Switched from Nifedipine‐GITS to Nifedipine‐CC

et al. 1999

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Chronotherapy With Nifedipine GITS in Hypertensive Patients: Improved Efficacy and Safety With Bedtime Dosing

Hermida

Ayala

Mojón

et al. 2008

American Journal of Hypertension

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Nifedipine Gastrointestinal Therapeutic System versus Nifedipine Coat-Core: Comparison of Efficacy via 24-Hour Ambulatory Blood Pressure Monitoring

Abstract: GITS and CC demonstrated clinically equivalent antihypertensive efficacy in the study population. The CC produce may have a higher rate of adverse effects, but drug discontinuation was uncommon.

Cited by 6 publications

References 10 publications

Dose‐ And Administration Time‐Dependent Effects Of Nifedipine Gits On Ambulatory Blood Pressure In Hypertensive Subjects

Dose‐ And Administration Time‐Dependent Effects Of Nifedipine Gits On Ambulatory Blood Pressure In Hypertensive Subjects

Comparison of 24‐Hour Ambulatory Blood Pressure Data in Hypertensive Patients Switched from Nifedipine‐GITS to Nifedipine‐CC

Chronotherapy With Nifedipine GITS in Hypertensive Patients: Improved Efficacy and Safety With Bedtime Dosing

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