Nifedipine for primary dysmenorrhoea

Earl, Rachel; Grivell, Rosalie M

doi:10.1002/14651858.cd012912

Cited by 4 publications

(6 citation statements)

References 12 publications

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“…Calcium channel blockers are another group of drugs investigated in relation to dysmenorrhea treatment [54,[62][63][64][65]. In general, calcium channel blockers are primarily indicated for the treatment of hypertension [62,63].…”

Section: Pharmacological Treatment Options For Menstrual Painmentioning

confidence: 99%

“…However, by reducing contractility of the vascular smooth muscles they also inhibit uterine contractions [63]. The studies to date have demonstrated that administering 20-40 mg of nifedipine, of blocking calcium channels properties to women provided them with a relief from menstrual pain, but was also associated with such adverse effects as tachycardia, hot flushes and headaches [64,65].…”

Section: Pharmacological Treatment Options For Menstrual Painmentioning

confidence: 99%

See 1 more Smart Citation

Inflammatory Markers in Dysmenorrhea and Therapeutic Options

Barcikowska

Rajkowska-Labon

Grzybowska

et al. 2020

IJERPH

138

115

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Dysmenorrhea often significantly reduces the quality of women’s life and is still an important public health problem. Despite numerous studies, the pathomechanism of dysmenorrhea is not fully understood. Previous research indicates the complexity of biochemical reactions between the endocrine, vascular, and immune systems. Prostaglandins play a major role in the pathomechanism of dysmenorrhea. In contrast, cytokines and other proinflammatory factors in primary dysmenorrhea are less studied. In addition to the applied pharmacotherapy, more and more studies proving the effectiveness of non-pharmacological methods appear. Therefore, the present work contains a review of the latest research concerning factors involved in dysmenorrhea, as well as therapeutic options. In the literature search, authors used online databases, PubMed, and clinitrials.gov and browsed through individual gynecology, physiotherapy journals and books.

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Section: Pharmacological Treatment Options For Menstrual Painmentioning

confidence: 99%

Section: Pharmacological Treatment Options For Menstrual Painmentioning

confidence: 99%

Inflammatory Markers in Dysmenorrhea and Therapeutic Options

Barcikowska

Rajkowska-Labon

Grzybowska

et al. 2020

IJERPH

138

115

View full text Add to dashboard Cite

show abstract

“…Based on pathophysiology, dysmenorrhea is divided into primary dysmenorrhea (PD) and secondary dysmenorrhea [ 2 ]. PD refers to cyclic menstrual pain in the absence of pelvic anomalies [ 2 , 7 , 8 ] while secondary dysmenorrhea is caused by identifiable pathological conditions, such as adenomyosis, endometriosis, fibroids, and pelvic inflammatory disease [ 2 , 4 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

The Establishment of a Mouse Model of Recurrent Primary Dysmenorrhea

Fang

Zhang

et al. 2022

IJMS

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Primary dysmenorrhea is one of the most common reasons for gynecologic visits, but due to the lack of suitable animal models, the pathologic mechanisms and related drug development are limited. Herein, we establish a new mouse model which can mimic the periodic occurrence of primary dysmenorrhea to solve this problem. Non-pregnant female mice were pretreated with estradiol benzoate for 3 consecutive days. After that, mice were injected with oxytocin to simulate menstrual pain on the 4th, 8th, 12th, and 16th days (four estrus cycles). Assessment of the cumulative writhing score, uterine tissue morphology, and uterine artery blood flow and biochemical analysis were performed at each time point. Oxytocin injection induced an equally severe writhing reaction and increased PGF2α accompanied with upregulated expression of COX-2 on the 4th and 8th days. In addition, decreased uterine artery blood flow but increased resistive index (RI) and pulsatility index (PI) were also observed. Furthermore, the metabolomics analysis results indicated that arachidonic acid metabolism; linoleic acid metabolism; glycerophospholipid metabolism; valine, leucine, and isoleucine biosynthesis; alpha-linolenic acid metabolism; and biosynthesis of unsaturated fatty acids might play important roles in the recurrence of primary dysmenorrhea. This new mouse model is able to mimic the clinical characteristics of primary dysmenorrhea for up to two estrous cycles.

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“…The prevalence of dysmenorrhea sufferers in Indonesia is 64.5% 2 . Research shows that women with dysmenorrhea have high levels of the hormone prostaglandins, the uterine muscle responds to high prostaglandins by contracting forcibly, causing low oxygen levels, causing abdominal pain 3,4 . Symptoms of dysmenorrhea often occur on the first or second day of menstruation 5 .…”

mentioning

confidence: 99%

“…Prevalensi penderita dismenorea di Indonesia adalah sebesar 64,5% 2 . Penelitian menunjukkan bahwa wanita dengan dismenorea memiliki kadar hormon prostaglandin yang tinggi, otot rahim merespon prostaglandin yang tinggi dengan berkontraksi secara paksa, menyebabkan kadar oksigen rendah sehingga timbul rasa sakit pada perut 3,4 . Gejala dismenorea sering terjadi pada hari pertama atau kedua menstruasi 5 .…”

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Pengaruh Abdominal Stretching Exercise Terhadap Penurunan Nyeri Dysmenorrhoea

Rodiah¹,

Hidayanti

2022

JKS

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Kesehatan Reproduksi adalah kesehatan secara fisik, mental, dan kesejahteraan sosial secara utuh pada semua hal yang berhubungan dengan sistem dan fungsi, serta proses reproduksi dan bukan hanya kondisi yang bebas dari penyakit dan kecacatan3. Nyeri haid adalah gangguan rasa nyaman yang timbul dari sistem reproduksi wanita pada saat menstruasi1. Dysmenorrhoea terjadi di perut bagian bawah pinggang yang menjelang haid atau selama haid akibat kontraksi otot rahim. Gejala dysmenorrhoea sering terjadi pada hari pertama atau kedua menstruasi2. Evidence based case report ini bertujuan untuk mengidentifikasi pengaruh Abdominal Stretching Exercise terhadap penurunan nyeri dysmenorrhoea. Penelusuran artikel mengenai pengaruh Abdominal Stretching Exercise terhadap penurunan nyeri dysmenorrhoea dilakukan di e-data based Garuda, sehingga didapatkan 3 artikel dengan desain penelitian Pre Eksperimen dan Quasi Eksperimen dan memenuhi kriteria inklusi yang telah ditentukan sebelumnya, kemudian dilakukaan telaah jurnal, dan didapatkan jika Abdominal Stretching Exercise mempengaruhi penurunan nyeri dysmenorrhoea dan dapat diterapkan pada pasien.

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Nifedipine for primary dysmenorrhoea

Cited by 4 publications

References 12 publications

Inflammatory Markers in Dysmenorrhea and Therapeutic Options

Inflammatory Markers in Dysmenorrhea and Therapeutic Options

The Establishment of a Mouse Model of Recurrent Primary Dysmenorrhea

Pengaruh Abdominal Stretching Exercise Terhadap Penurunan Nyeri Dysmenorrhoea

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