Nifedipine attenuates the intraocular pressure response to intubation following succinylcholine

Indu, B.; Batra, Y. K.; Puri, Goverdhan D; Singh, Harpreet

doi:10.1007/bf03010763

Cited by 38 publications

(8 citation statements)

References 18 publications

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“…While several laboratories have reported that systemic administration of verapamil in rabbits (Segarra et al 1993) and nifedipine and nimodipine in men (Kelly and Walley 1988;Bose et al 1995) does not reduce intraocular pressure, others have found ocular hypertensive responses after intravenous verapamil and diltiazem administration (Beatty et al 1984) or ocular hypotensive responses after oral or intravenous administration of verapamil, nifedipine, nitrendipine and diltiazem (Green and Kim 1977;Indu et al 1989;Monica et al 1990;Gonzáles et al 1995).…”

Section: Introductionmentioning

confidence: 99%

A long-lasting hypotensive effect of topical diltiazem on the intraocular pressure in conscious rabbits

Santafé

Ibarreta

Segarra

et al. 1997

Naunyn-Schmiedeberg's Arch Pharmacol

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The effect of calcium channel blockers on intraocular pressure and aqueous humor dynamics remains still controversial, although preliminary evidence suggests that these drugs may be beneficial in the management of ocular hypertension and low-tension glaucoma. Having previously reported the ocular hypotensive effect of topical nifedipine and verapamil in albino rabbits, the original aim of the present work was to evaluate the effect of topical diltiazem on aqueous humor dynamics in this species. Intraocular pressure was measured with a manual applanation tonometer. The experiments examining the ocular actions of diltiazem were carried out in two stages. In the first one, short term effects of topical diltiazem on intraocular pressure were studied in groups of 13 albino rabbits receiving 8 different doses of the drug in order to obtain a dose-response curve. Tonographies were performed in 13 anaesthetized animals before and 90 min after drug instillation. In a second phase, the persistence of the effect of diltiazem on intraocular pressure was examined in 6 groups of 10 rabbits each receiving three different doses of the drug. Topical diltiazem was found to lower intraocular pressure in a dose-related fashion. The maximum response to diltiazem was greater and the ED50 lower than those previously reported for nifedipine and verapamil. In the tonographic study, diltiazem was shown to reduce the facility of aqueous humor outflow and inflow. Diltiazem exhibited a long lasting effect on intraocular pressure that was again dose-related. Depending on the dose administered, the calculated time necessary for the peak effect to be halved ranged from 0.6 to 7.0 days. Due to the intensity and the persistence of its intraocular pressure-lowering effect, diltiazem shows great potential for the treatment of glaucoma, since a daily or less frequent administration may be enough to control ocular hypertension.

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Section: Introductionmentioning

confidence: 99%

A long-lasting hypotensive effect of topical diltiazem on the intraocular pressure in conscious rabbits

Santafé

Ibarreta

Segarra

et al. 1997

Naunyn-Schmiedeberg's Arch Pharmacol

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“…Although the current hemodynamic findings and previous pharmacologic studies 7,8 are consistent with a more pronounced negative inotropic effect at the higher anesthetic doses, it is unlikely that this effect alone was responsible for the impaired cardiac output responses during ANH in the study of Van der Linden et al In the case of halothane, the impact of a reduced arterial blood pressure, i.e., coronary perfusion pressure, must also be considered; arterial blood pressure averaged only 43 Ϯ 7 mmHg at the critical point during ANH (hemoglobin 4.5 Ϯ 1.6 g/dl). Previous studies have suggested that this combination of arterial pressure and hemoglobin concentration results in a maldistribution of myocardial blood flow, i.e., subendocardial hypoperfusion, leading to myocardial lactate production, ischemic changes in the electrocardiogram, and ultimately impairment in global cardiac function.…”

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confidence: 58%

Role of Extraocular Pressure in Open Globe Injury: In Reply

Vachon¹,

Warner²,

Bacon

2004

Anesthesiology

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“…Various methods to attenuate the effects of succinylcholine and intubation on IOP include selftaming 11 , pretreatment with nondepolarizing neuromuscular blocking agents, [12][13][14] lidocaine, 15 narcotics, nifedipine. 16 However, no modality is devoid of drawbacks and limitations.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of dexmedetomidine premedication on attenuation of intraocular pressure changes after succinylcholine and endotracheal intubation

2020

IJCA

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Introduction: Succinylcholine, is one of the most commonly used muscle relaxant for rapid sequence airway management. It increases the Intraocular pressure (IOP) which is deleterious in open globe injuries. We studied the effects of Inj. dexmedetomidine, a highly selective α2-adrenoceptor agonist, on IOP and hemodynamic responses to succinylcholine and tracheal intubation. Materials and Methods: Sixty ASA I-II patients, scheduled for elective non-ophthalmic surgeries requiring general anesthesia were randomly premedicated by intravenous Inj. dexmedetomidine 0.4 µg/kg (Group-D) or saline (Group-S) (30 patients each group). Heart rate (HR), mean arterial pressure (MAP), and IOP (using Schiotz tonometer) were measured 10 minutes before and after the premedication, 30 seconds after succinylcholine and at 1, 5 and 10 minutes after intubation. Results: Ten minutes after Inj. dexmedetomidine administration, there was marked decrease in IOP. After intubation there was a rise in IOP, however it remained below baseline IOP (p=0.315) and remained low at 10 th minute after intubation (p<0.001) which was statistically significant. In the control group, there was a significant rise in IOP following Inj. succinylcholine and intubation which remained above baseline IOP even at 10 th minute after intubation. HR, Systolic and diastolic blood pressure, and MAP markedly increased at 1 minute following intubation in the control group whereas in dexmedetomidine group, they remained below baseline (p<0.001). Conclusions: Intravenous dexmedetomidine at a dose of 0.4 μg/kg can be used for attenuation of rise in IOP associated with succinylcholine and tracheal intubation in patients with open globe injuries.

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Nifedipine attenuates the intraocular pressure response to intubation following succinylcholine

Cited by 38 publications

References 18 publications

A long-lasting hypotensive effect of topical diltiazem on the intraocular pressure in conscious rabbits

A long-lasting hypotensive effect of topical diltiazem on the intraocular pressure in conscious rabbits

Role of Extraocular Pressure in Open Globe Injury: In Reply

Efficacy of dexmedetomidine premedication on attenuation of intraocular pressure changes after succinylcholine and endotracheal intubation

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