Nifedipine Alleviates Alterations in Hippocampal Kindling After Repeated Ethanol Withdrawal

Veatch, Lynn M.; Gonzalez, Larry P.

doi:10.1097/00000374-200004000-00022

Cited by 6 publications

(7 citation statements)

References 43 publications

(25 reference statements)

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“…Diazepam treatment during intermittent withdrawal episodes reduced, but did not prevent, these effects. These effects were completely blocked, however, by treatment with the calcium channel antagonist nifedipine (Veatch and Gonzalez, 1999).…”

Section: Long-term Changes In Cns Function After Repeated Alcohol Witmentioning

confidence: 94%

Alcohol Withdrawal Kindling: Mechanisms and Implications for Treatment

Gonzalez

Veatch

Ticku

et al. 2001

Alcoholism Clin & Exp Res

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This article represents the proceedings of a workshop at the 2000 ISBRA Meeting in Yokohama, Japan. The chair was Larry P. Gonzalez. The presentations were (1) EEG indices of sensitization in a murine model of repeated ethanol withdrawals, by Lynn M. Veatch; (2) Long-term changes in central nervous system function after repeated alcohol withdrawals: Recommendations for the treatment of acute withdrawal, by Larry P. Gonzalez; (3) Differential regulation of GABA A and NMDA receptors by repeated ethanol treatment in cultured mammalian neurons, by Maharaj K. Ticku; and (4) Involvement of GABA A and NMDA receptors in alcohol withdrawal kindling: Implications for treatment, by Howard C. Becker.

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Section: Long-term Changes In Cns Function After Repeated Alcohol Witmentioning

confidence: 94%

Alcohol Withdrawal Kindling: Mechanisms and Implications for Treatment

Gonzalez

Veatch

Ticku

et al. 2001

Alcoholism Clin & Exp Res

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“…Reduced chronic alcohol-induced seizures [313] Nifedipine and nimodipine [314] Nicotine Locomotor activity Nimodipine Reduced acute nicotine induced locomotor activity [315] Behavioral sensitization; Locomotor activity Nimodipine, verapamil and diltiazem Suppressed development and expression of behavioral sensitization [316] Nifedipine [16] consumption [301][302][303][304], and nifedipine, verapamil, and diltiazem decrease the heightened locomotor activity induced by low doses of ethanol [301,307,308]. In contrast, a study reported that nifedipine and verapamil had no impact on the ethanol-induced increase in locomotor activity [309], nor did isradipine, nifedipine or nimodipine on ethanol consumption [305,306].…”

Section: Nifedipinementioning

confidence: 99%

From Gene to Behavior: L-Type Calcium Channel Mechanisms Underlying Neuropsychiatric Symptoms

2017

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The L-type calcium channels (LTCCs) Ca1.2 and Ca1.3, encoded by the CACNA1C and CACNA1D genes, respectively, are important regulators of calcium influx into cells and are critical for normal brain development and plasticity. In humans, CACNA1C has emerged as one of the most widely reproduced and prominent candidate risk genes for a range of neuropsychiatric disorders, including bipolar disorder (BD), schizophrenia (SCZ), major depressive disorder, autism spectrum disorder, and attention deficit hyperactivity disorder. Separately, CACNA1D has been found to be associated with BD and autism spectrum disorder, as well as cocaine dependence, a comorbid feature associated with psychiatric disorders. Despite growing evidence of a significant link between CACNA1C and CACNA1D and psychiatric disorders, our understanding of the biological mechanisms by which these LTCCs mediate neuropsychiatric-associated endophenotypes, many of which are shared across the different disorders, remains rudimentary. Clinical studies with LTCC blockers testing their efficacy to alleviate symptoms associated with BD, SCZ, and drug dependence have provided mixed results, underscoring the importance of further exploring the neurobiological consequences of dysregulated Ca1.2 and Ca1.3. Here, we provide a review of clinical studies that have evaluated LTCC blockers for BD, SCZ, and drug dependence-associated symptoms, as well as rodent studies that have identified Ca1.2- and Ca1.3-specific molecular and cellular cascades that underlie mood (anxiety, depression), social behavior, cognition, and addiction.

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“…Additionally, in the abovementioned study, nifedipine (in doses of 10 mg/kg) did not reduce the incidence of clonic seizures, but inhibited tonic seizures and the progression of clonic seizures into maximal tonic seizures in four of eight animals (35). On the other hand, there are some studies that report opposing findings in the literature (16,19,22,25,26,36,44,46).…”

Section: Resultsmentioning

confidence: 99%

“…It has been shown that this drug displays antiepileptic activity in pentylenetetrazol (PTZ)-induced epilepsy (25,36), maximal electroshock (MES)-evoked seizures in a dose dependent manner (19), hippocampalkindled seizures (46) and picrotoxin-induced seizures (44). Contrary to expectations, nifedipine did not influence aminophylline-induced seizures (12), seizures elicited by MES (36) and the protective action of diazepam against PTZ-induced seizures (13).…”

Section: Yilmaz I Et Al: Nifedipine and Hippocampal Neuron Numbermentioning

confidence: 91%

Effect of nifedipine on hippocampal neuron number in penicillin-induced epileptic rats

Yılmaz

Akdogan²,

Kaya³

et al. 2013

Turkish Neurosurgery

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AIm: Epileptic seizures lead to neuronal loss in the hippocampus. Experimental epilepsy can be induced by direct application of various chemicals to cerebral cortex. Nifedipine is an L-type voltage-dependent calcium channel blocker. In spite of several studies that show the seizure-suppressing effects of nifedipine, it has been shown that nifedipine does not suppress but conversely increases epileptic seizures. Similarly, contradictory effects of nifedipine have been reported, such as neuroprotection, failed neuroprotection and neurotoxicity. We therefore aimed to investigate the effect of nifedipine on hippocampal neuronal loss in penicillin induced epileptic rats in this study. mATeRIAL and meTHods:The effect of nifedipine on total hippocampal neuron number was estimated by using the optical fractionator method (an unbiased stereological method) in penicillin-G induced epileptic rats. ResuLTs:The total number of hippocampal neurons in the control group was 183687 ± 3184. In the penicillin-induced group, the total neuron number significantly decreased to 146318 ± 3042 compared to the control group. In the nifedipine group, the neuron number significantly decreased to 128873 ± 1157 compared to both control and penicillin-induced groups.CoNCLusIoN: Nifedipine increased neuronal loss and did not suppress epileptic seizures in penicillin-induced epileptic rats. Nifedipine could not protect against hippocampal neuronal loss in penicillin-induced epileptic rats.KeywoRds: Penicillin epilepsy model, Nifedipine, Hippocampus, Neuron number, The optical fractionator method, Rat, Epilepsy, Seizure ÖZ AmAÇ: Epileptik nöbetler hipokampusta nöron kaybına yol açmaktadır. Çeşitli kimyasalların beyin korteksine direkt olarak uygulanmasıyla deneysel epilepsi oluşturulabilir. Nifedipin, L-tipi voltaj bağımlı kalsiyum kanal blokörüdür. Nifedipinin nöbet baskılayıcı etkilerini gösteren çeşitli çalışmalar bulunduğu gibi, epileptik nöbetleri baskılamadığı tam tersine arttırdığı da gösterilmiştir. Benzer şekilde, nifedipinin çelişkili etkileri bildirilmiştir; olumlu -olumsuz nöroprotektif (nöron koruyucu) ve nörotoksisite gibi. Bu nedenle, bu çalışmada, penisilin ile deneysel epilepsi oluşturulan sıçanlarda nifedipinin hipokampal nöron kaybı üzerine etkisini araştırmayı amaçladık. yÖNTem ve GeReÇLeR: Nifedipinin penisilin G ile deneysel epilepsi oluşturulan sıçanlarda toplam hipokampal nöron sayısına etkisi tarafsız (objektif ) bir stereolojik metot olan optik parçalama yöntemi ile değerlendirildi.BuLGuLAR: Kontrol grubunun toplam hipokampal nöron sayısı 183687 ± 3184 idi. Penisilin grubunun toplam nöron sayısı kontrol grubuna göre anlamlı olarak düşüktü (146318 ± 3042). Penisilin+nifedipin grubunun toplam nöron sayısı (128873 ± 1157) hem kontrol hem de penisilin grubuna göre istatistiksel olarak anlamlı olarak azalmış bulundu. soNuÇ: Nifedipinin epileptik sıçanlarda nöron kaybını arttırdığı ve epileptik nöbetleri baskılamadığı ortaya kondu. Nifedipin, penisilin ile deneysel epilepsi oluşturulan sıçanlarda ortaya çıkan nöron ka...

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Nifedipine Alleviates Alterations in Hippocampal Kindling After Repeated Ethanol Withdrawal

Cited by 6 publications

References 43 publications

Alcohol Withdrawal Kindling: Mechanisms and Implications for Treatment

Alcohol Withdrawal Kindling: Mechanisms and Implications for Treatment

From Gene to Behavior: L-Type Calcium Channel Mechanisms Underlying Neuropsychiatric Symptoms

Effect of nifedipine on hippocampal neuron number in penicillin-induced epileptic rats

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