Nifedipine Aerosol Attenuates Airway Constriction in Dogs with Hyperreactive Airways<sup>1–</sup><sup>4</sup>

Brugman, Thomas M.; Darnell, Michael; Hirshman, Carol A.

doi:10.1164/arrd.1983.127.1.14

Cited by 49 publications

(10 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The contraction of bronchial smooth muscle and the release of chemical mediators from mast cells are both dependent on the influx of calcium ions across cell membranes from the ex tracellular to intracellular compartment. Several studies showed the effect of cal cium antagonists (verapamil and nifedi pine) on exercise-induced asthma [1,3,21] and even on antigen-induced bronchocon striction [2,12,22,23]. Some investigators demonstrated the antagonist action of verapamil and nifedipine on the anaphyl actic contraction of smooth muscle [14] and on the release of platelet-activating factor and slow-reacting substances of an aphylaxis from human neutrophils and from human lung [4,5].…”

Section: Discussionmentioning

confidence: 99%

Effect of Sodium Cromoglycate and Nifedipine on Adenosine-Induced Bronchoconstriction

Crimi

Palermo²,

Vancheri³

et al. 1988

Respiration

View full text Add to dashboard Cite

Inhaled adenosine causes bronchoconstriction in asthmatic patients. In 7 symptom-free asthmatics a study was performed to investigate the effect of sodium cromoglycate and nifedipine on adenosine-induced bronchoconstriction. All patients were challenged with increasing doses (from 0.03 to 2 mg) of nebulized adenosine to assess airway reactivity. The same procedure was repeated on different days at the same time each morning after administration of placebo and drugs in a randomized double-blind study. Airway response was measured as the forced expiratory volume in 1 s (FEV₁). The PD₂₀ value and the fall of FEV₁ at the provocative dose were calculated. The PD₂₀ data were modified in log values and the statistical analysis was performed by two-way analysis of variance. Mean decrease of FEV₁ after adenosine challenge was 26.02 and 28.87% with placebo sodium cromoglycate and placebo nifedipine, respectively. Sodium cromoglycate and nifedipine gave a mean decrease of FEV₁ of 6.44% (p < 0.05) and 22.22%, respectively. PD₂₀ values (geometric mean) after adenosine inhalation were 0.72 and 0.74 mg for placebo sodium cromoglycate and placebo nifedipine and 0.86 mg for nifedipine. Sodium cromoglycate gave a significant protection against adenosine in all subjects and in no case did the maximum dose used (2 mg) result in a fall in FEV₁ value > 20%. Adenosine antagonism could be considered as a possible factor contributing to the pharmacologic efficacy of sodium cromoglycate in asthmatic patients. No protective effect was noticed with nifedipine. The results demonstrate that adenosine-induced bronchoconstriction is not related to calcium metabolism, even if the data provided do not completely exclude a possible action of adenosine on calcium channels.

show abstract

Section: Discussionmentioning

confidence: 99%

Effect of Sodium Cromoglycate and Nifedipine on Adenosine-Induced Bronchoconstriction

Crimi

Palermo²,

Vancheri³

et al. 1988

Respiration

View full text Add to dashboard Cite

show abstract

“…According to previous reports, calcium antagonists attenuate bronchoconstriction induced by cholinergic agents in dogs [10], guinea pigs [11], patients with coronary ar tery disease [12], and normal human sub jects [13]. Histamine-induced bronchocon striction is also said to be inhibited by cal cium antagonists in guinea pigs [11], dogs [14], and normal human subjects [13].…”

Section: Discussionmentioning

confidence: 99%

Effect of Nifedipine on Dose-Response Curves to Acetylcholine and Histamine Measured during Quiet Breathing

Tomioka¹,

Arai²,

Kuroiwa³

et al. 1986

Respiration

View full text Add to dashboard Cite

We have investigated the effect of nifedipine on acetylcholine-induced bronchoconstriction in 8 asthmatics and on histamine-induced bronchoconstriction in another 8 asthmatics on a single-blind basis. Expiratory spirograms were done at the beginning of the examination in all subjects, and repeated after 10 mg of oral nifedipine or a placebo. The change of respiratory resistance during the inhalation of acetylcholine or histamine was recorded continuously by an Astograph®. Using this device, we were able to obtain the direct-writing dose-response curve of respiratory resistance measured during quiet breathing. Resting airway tone appeared to be generally unaffected by nifedipine, as there was no significant change in baseline spirograms. Nifedipine increased significantly the threshold of bronchial responsiveness, i.e., the cumulative dose of acetylcholine (D_min) at which the respiratory resistance started to increase, compared with placebo (p < 0.02). However, S_d, the slope of the increasing rate of respiratory resistance in the dose-response curve, was not attenuated by nifedipine. In histamine inhalation tests, neither D_min nor S_d were modified by nifedipine. The discrepancy observed between the effects of nifedipine on acetylcholine- and histamine-induced bronchoconstriction may imply that, in asthmatics, nifedipine exerts its effect mainly by stabilizing mast cells rather than by directly inhibiting bronchial smooth muscle contractility. This hypothesis is based on the fact that mast cells have acetylcholine receptors on their surfaces but no histamine H₁-receptors

show abstract

“…The ef fects of nifedipine on various nonimmunological stimuli other than exercise are, however, still controversial. Fanta et al [20] in the guinea pig and Brugman et al [21] in the dog were both able to show that nifedipine inhibited or at least attenuated histamine-and/or metacholine-induced bronchoconstriction. Williams et al [10] confirmed these animal findings in hu mans by showing that the concentration of histamine causing a 20% fall in FEV| in asthmatics was increased 3-fold by preme dication with nifedipine 20 mg.…”

Section: Discussionmentioning

confidence: 99%

Inhibition of Acetylcholine-Induced Bronchoconstriction in Asthmatics by Nifedipine

et al. 1986

View full text Add to dashboard Cite

The calcium-dependent constriction of bronchial smooth muscle cells and release of mediators derived from mast cells is important in the pathophysiology of asthma. We hypothesized that nifedipine, a slow calcium channel blocker, would inhibit or attenuate acetylcholine-induced bronchoconstriction in asthmatics. Because one consequence of mast cell activation is the release of platelet-activating factor, we wondered whether thromboxane levels would be increased during acute bronchial constriction in asthmatics. Bronchoconstriction was induced in 8 asthmatics (6 men, 2 women) by acetylcholine; each subject was pretreated either with placebo or nifedipine (20 mg sublingually) on 2 separate days. Vital capacity, forced expiratory volume in 1 s, peak expiratory flow rates and oscillatory resistance were measured prior to and after the intake of placebo or nifedipine as well as after an acetylcholine challenge. Pretreatment with nifedipine significantly attenuated acetylcholine-induced changes in all four lung function parameters studied, but did not significantly influence the increase in thromboxane B2 plasma concentrations observed after the acetylcholine challenge. From these data we conclude that nifedipine inhibits the acetylcholine-induced bronchoconstriction in asthmatics. This effect may be either a direct action on bronchial smooth muscle or may be due to the inhibition of mediators other than thromboxane.

show abstract

Nifedipine Aerosol Attenuates Airway Constriction in Dogs with Hyperreactive Airways^1–⁴

Cited by 49 publications

References 0 publications

Effect of Sodium Cromoglycate and Nifedipine on Adenosine-Induced Bronchoconstriction

Effect of Sodium Cromoglycate and Nifedipine on Adenosine-Induced Bronchoconstriction

Effect of Nifedipine on Dose-Response Curves to Acetylcholine and Histamine Measured during Quiet Breathing

Inhibition of Acetylcholine-Induced Bronchoconstriction in Asthmatics by Nifedipine

Contact Info

Product

Resources

About

Nifedipine Aerosol Attenuates Airway Constriction in Dogs with Hyperreactive Airways1–4

Cited by 49 publications

References 0 publications

Effect of Sodium Cromoglycate and Nifedipine on Adenosine-Induced Bronchoconstriction

Effect of Sodium Cromoglycate and Nifedipine on Adenosine-Induced Bronchoconstriction

Effect of Nifedipine on Dose-Response Curves to Acetylcholine and Histamine Measured during Quiet Breathing

Inhibition of Acetylcholine-Induced Bronchoconstriction in Asthmatics by Nifedipine

Contact Info

Product

Resources

About

Nifedipine Aerosol Attenuates Airway Constriction in Dogs with Hyperreactive Airways^1–⁴